Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Microphysiological systems to Advance Precision medicine for Alzheimer's Disease and Related Dementias (MAP-AD)

Award Number: U54AG090792
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2030

Group Awards By:

View Award Description

Microphysiological systems to Advance Precision medicine for Alzheimer's Disease and Related Dementias (MAP-AD) - PROJECT ABSTRACT/SUMMARY IU MAP-AD Overall Abstract/Summary The Indiana University Microphysiological systems to Advance Precision medicine for AD/ADRD (IUMAP-AD) Center is committed to establishing a multi-component Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) Translational Center for Microphysiological Systems (MPS). AD is a leading cause of dementia worldwide, with current estimates of nearly 6 million Americans currently affected by the disease. AD is associated with many accompanying pathologies including inflammation and activation of microglia and astrocytes, dysfunction of vasculature, as well as synaptic and eventual neuronal loss. Additionally, recent studies have identified numerous genetic risk factors associated with AD/ADRD at loci with known functions in glial and vascular cell types. However, our understanding of how these genetic risk factors and cell types contribute to AD/ADRD pathology remains somewhat limited, especially in the human system. Thus, to overcome these shortcomings, we propose to build on our extensive knowledge and tools acquired from the ongoing MODEL-AD, TREAT-AD, and CLEAR-AD consortia at Indiana University, as well as our extensive expertise in induced pluripotent stem cell (iPSC)/organoids, intelligent systems, and AD/ADRD research across the University. Our overarching goal is to develop reproducible, scalable, and standardized 3D brain organoid-based MPS models that recapitulate key features of human AD/ADRD pathophysiology. In the process, we will also generate numerous resources for investigation among the research community which will be readily shared, including novel cell lines, protocols for the development and implementation of MPS models, and datasets derived from the use of MPS models. These models will thus serve as precision medicine research tools to investigate the complex biology of AD/ADRD and accelerate multiple aspects of drug discovery and preclinical drug development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,335,016 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	1	7/8/2025	NEW	$0
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	6/24/2025	NEW	$3,335,016
														Subtotal = $3,335,016

Grand Total All Awards = $3,335,016

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Microphysiological systems to Advance Precision medicine for Alzheimer's Disease and Related Dementias (MAP-AD)

Award Number: U54AG090792

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer