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The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)

Award Number: U54AG079753
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/23/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - PROJECT SUMMARY This is a component of a collaborative project within the Cellular Senescence Network (SenNet) Program. We have incorporated known senescence inducers (e.g. Doxorubicin, Palbociclib, high fat diet) in the mouse model and shared relevant tissues (lung, muscle, ovary) with other SenNet TMCs for analysis. In the parent grant to this supplement, we have established The Jackson Laboratory (JAX) Cellular Senescence Network Tissue Mapping Center (JAX-Sen TMC) focused on the analysis of mouse tissue to address a significant research and clinical need for improved biomarkers and cellular maps of senescence. Advances in our understanding of biological aging and the recognition of aging as a modifiable risk factor for many chronic diseases and geriatric syndromes are fueling a growing interest in the cellular underpinnings of the aging process. Despite recent progress in cellular senescence research and the discovery of new senolytics and senomorphics, we lack clear information regarding the role of cellular senescence in aging and age-related disease, and the effect of genetic variation on these phenomena. In the JAX-Sen TMC we are mapping senescent cells in the context of multiple age-matched tissues of genetically defined mouse cohorts, raised in standardized environments throughout their lifespan and defining senescent cell phenotypes associated to features of genetics, age and senolytic interventions. The tissues of specific focus within the JAX-Sen TMC are kidney, pancreas, heart, and placenta. This supplement aims to generate detailed tissue mapping data on the mouse pancreas and kidney derived from our senescence inducers study and perform the analysis of this data using our existing framework. Specifically, we will employ bulk RNA-seq, H&E, CODEX multiplexed antibody imaging, and Xenium in situ RNA spatial profiling. Senescent cells identified from the senescent inducers experiment will be directly compared to those from natural aging, and provide the foundation for future senolytic/senomorphic functional studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $259,622 )
2025	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Trans-NIH Research Support	002	3	6/17/2025	SUPPLEMENT FOR EXPANSION	$259,622
2025	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Trans-NIH Research Support	003	3	6/19/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	3	4/30/2025	NON-COMPETING CONTINUATION	$0
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	3	3/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $259,622

Issue Date FY: 2024 ( Subtotal = $2,722,008 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	3	7/12/2024	NON-COMPETING CONTINUATION	$2,722,008
														Subtotal = $2,722,008

Issue Date FY: 2023 ( Subtotal = $2,839,947 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	2	7/26/2023	NON-COMPETING CONTINUATION	$2,839,947
2023	2022	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	1	2/28/2023	NEW	$0
														Subtotal = $2,839,947

Issue Date FY: 2022 ( Subtotal = $2,486,085 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	1	8/12/2022	NEW	$2,486,085
														Subtotal = $2,486,085

Grand Total All Awards = $8,307,662

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The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)

Award Number: U54AG079753

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/23/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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