Thursday, October 2, 2025 10/2/2025

Extracellular Vesicles for Gaining Insights into Tissue Senescent Signatures: A SenNET Pilot and Exploratory Project

Award Number: U54AG075941
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Extracellular Vesicles for Gaining Insights into Tissue Senescent Signatures: A SenNET Pilot and Exploratory Project - Abstract This Administrative Supplement to KAPP-Sen Tissue Mapping Center (TMC) award (U54AG075941) funded by National Institute of Aging to leverage recent advances in the development of technologies used for the detection of senescence markers within tissue-speciﬁc extracellular vesicles (EVs). The PA-20-272 (Administrative Supplements to Existing NIH Grants and Cooperative Agreements) notes that this funding mechanism be used to cover cost increases that are associated with achieving certain new research objectives, as long as the research objectives are within the original scope of the peer-reviewed and approved project. Speciﬁc Aims of U54AG075941 include Aim 1: Coordinate research activities across KAPP-Sen TMC Collaborative sites in support of Sen-Net goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas and placenta. Aim 2: Obtain tissues from healthy kidney transplant donors (kidneys, fat, skin), C-section pregnancies (placenta, cord, fat, skin), outpatient healthy donor biopsies (fat, skin), beating heart brain dead donors (full pancreas) and IIPD/Prodo (dispersed pancreas). Aim 3: Generate highest-quality data pertaining to cellular senescence including scRNA- Seq, snRNA-Seq, spatial transcriptomics, immunohistochemistry and Telomere-associated DDR foci (TAFs) in all tissues. Aim 4: Perform high-level integrative data analysis required for the creation of aUases of human cellular senescence in collaboration with other TMCs, CODDC and NIH staff. Our Administrative Supplement proposal seeks to leverage ongoing work conducted by our KAPP- Sen TMC to create maps of senescent cells in Kidneys, Adipose tissues, Pancreas, and Placenta with advances involving new techniques designed to isolate, identify, characterize, and quantify tissue-speciﬁc EVs from blood and urine, combined with senescent biomarkers. Our Overarching Hypothesis raises the rather intriguing possibility that EV subsets and their protein cargo components may function as a liquid biopsy, thus permitting the non-invasive qualitative and quantitative evaluation of the senescent cell burden residing within the tissues from which those EVs likely originate. Furthermore, suppose future evidence was to support this postulate. In that case, such a development might permit clinicians to one day link peripheral blood- or urine- borne EV biomarker data to information residing in curated high-resolution senescent cell data obtained via SenNET.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,042,784 )
2025	2025	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	003	5	8/26/2025	SUPPLEMENT FOR EXPANSION	$342,784
2025	2025	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	002	5	8/13/2025	NON-COMPETING CONTINUATION	$2,700,000
2025	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	001	4	5/15/2025	NON-COMPETING CONTINUATION	$0
2025	2021	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	000	1	11/14/2024	NEW	$0
														Subtotal = $3,042,784

Issue Date FY: 2024 ( Subtotal = $2,700,000 )
2024	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	001	4	8/27/2024	NON-COMPETING CONTINUATION	$2,700,000
2024	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	000	3	4/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,700,000

Issue Date FY: 2023 ( Subtotal = $2,700,000 )
2023	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Trans-NIH Research Support	000	3	8/15/2023	NON-COMPETING CONTINUATION	$2,700,000
														Subtotal = $2,700,000

Issue Date FY: 2022 ( Subtotal = $2,700,000 )
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Trans-NIH Research Support	001	2	9/9/2022	NON-COMPETING CONTINUATION	$2,700,000
2022	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Trans-NIH Research Support	000	1	9/7/2022	NEW	$0
														Subtotal = $2,700,000

Issue Date FY: 2021 ( Subtotal = $2,700,000 )
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Trans-NIH Research Support	000	1	9/22/2021	NEW	$2,700,000
														Subtotal = $2,700,000

Grand Total All Awards = $13,842,784

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Extracellular Vesicles for Gaining Insights into Tissue Senescent Signatures: A SenNET Pilot and Exploratory Project

Award Number: U54AG075941

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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