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IUSM TREAT-AD Center

Award Number: U54AG065181
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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IUSM TREAT-AD Center - PROJECT SUMMARY/ABSTRACT The strategic goal of the Indiana University School of Medicine Purdue University TaRget Enablement to Accelerate Therapy Development for Alzheimer's Disease (IUSM-Purdue TREAT-AD) Center is to integrate sophisticated disease biology and drug discovery capabilities to create Target Enabling Packages (TEPs) for the study of emerging Alzheimer's disease hypotheses (beyond amyloid beta) and create the foundation for new classes of therapeutics. The IUSM-Purdue TREAT-AD Center has established itself as a strategic and operational partner for NIA supported consortia. By design, we provide drug discovery capability to bridge the new disease target hypothesis work of AMP-AD with well characterized molecular entities for evaluation in cellular and in vivo models based on human pathology, genetics, and translational biomarkers. To accomplish this mission, we have assembled a world-class team of scientists and capabilities from IUSM, Purdue University, University of Pittsburgh School of Medicine, and the Indiana Biosciences Research Institute (IBRI). This team has considerable expertise in AD biology, pharma drug discovery and development, and in the core discovery technologies that drive the Center's contributions, deliverables and achievement of milestones. A key advantage and differentiated strength of our Center is the primary scientific coordination and administration through IUSM. This capability concentrates a strong and long-standing commitment to neurodegenerative research through co- presence with the NIA-supported Indiana Alzheimer's Disease Center under the direction of Dr. Andy Saykin, the MODEL-AD consortium under the direction of Dr. Bruce Lamb, and the Longitudinal Early Onset Alzheimer's Disease (LEAD) study under the direction of Dr. Liana Apostolova. Our aims are (1) Create a dynamic portfolio of well characterized neuroinflammation AD drug discovery targets representing novel intervention hypotheses that capitalizes on significant investments in basic research and emerging disease understanding; (2) Perform target validation and enablement studies to prioritize opportunities for therapeutic discovery; (3) Create high quality and well characterized molecules for prioritized targets that meet rigorous milestone criteria and are valued opportunities for further translational investment; (4) Enable global researchers with open access data and Target Enablement Packages (TEPs) to expand on the work of the TREAT-AD Consortium. Collectively, these aims will support the translation of new molecular entities into the clinic that will reduce neurodegeneration and improve cognition, thus advancing the NIH/NIA mission to develop novel therapies for AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $8,319,175 )
2026	2026	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	7	12/31/2025	NON-COMPETING CONTINUATION	$8,319,175
														Subtotal = $8,319,175

Issue Date FY: 2025 ( Subtotal = $8,323,362 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	6	12/12/2024	COMPETING CONTINUATION	$8,323,362
2025	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	5	3/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,323,362

Issue Date FY: 2023 ( Subtotal = $7,649,097 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	5	8/30/2023	SUPPLEMENT FOR EXPANSION	$351,158
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	5	8/10/2023	NON-COMPETING CONTINUATION	$7,297,939
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	4	12/8/2022	NON-COMPETING CONTINUATION	$0
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	4	5/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,649,097

Issue Date FY: 2022 ( Subtotal = $7,389,487 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	4	8/15/2022	NON-COMPETING CONTINUATION	$7,389,487
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	3	5/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,389,487

Issue Date FY: 2021 ( Subtotal = $7,846,641 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	3	8/26/2021	NON-COMPETING CONTINUATION	$7,452,927
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	2	4/8/2021	SUPPLEMENT FOR EXPANSION	$393,714
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	2	6/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,846,641

Issue Date FY: 2020 ( Subtotal = $7,700,751 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	2	8/31/2020	NON-COMPETING CONTINUATION	$7,457,353
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	2	9/14/2020	SUPPLEMENT FOR EXPANSION	$243,398
														Subtotal = $7,700,751

Issue Date FY: 2019 ( Subtotal = $5,774,436 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	1	9/13/2019	NEW	$0
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	9/12/2019	NEW	$5,774,436
														Subtotal = $5,774,436

Grand Total All Awards = $53,002,949

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IUSM TREAT-AD Center

Award Number: U54AG065181

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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