Sunday, October 27, 2024 10/27/2024

IU/JAX/PITT MODEL-AD Center: Prophylactic Treatment of Long acting GM-CSF (BBT-007) in B6.hAβsaa mice

Award Number: U54AG054345
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT OVERALL COMPONENT Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of basic biological mechanisms underlying AD, we do not yet know how to prevent AD or have an approved disease modifying intervention. Animal models of Alzheimer's disease (AD) have provided important insights into the pathophysiology of disease and suggested potential avenues for therapies; however, translation of these findings to the clinic has been largely unsuccessful. The MODEL-AD Consortium was initiated to generate and validate the next generation of mouse models of late-onset Alzheimer's disease (LOAD) as well as to perform rigorous preclinical testing of the most promising therapeutics in these models. Based on advances in human disease characterization driven by genetic, molecular, and imaging studies, we have created more than 40 LOAD mouse models carrying genetic risk variants. These models have been characterized using the same molecular and imaging modalities used in the clinic, revealing LOAD-relevant phenotypes not observed in prior mouse models. The IU/JAX/PITT MODEL-AD Center is now poised to leverage these existing models, protocols, and data to further our mission of creating translatable preclinical tools. The Indiana University (IU)/Jackson Laboratory (JAX)/University of Pittsburgh (IU/JAX/PITT) will leverage IU's and PITT's strengths in neurodegenerative research including 30+ years as an NIA-supported Alzheimer's Disease Center (ADRC) and considerable expertise in preclinical drug testing with JAX's eight decades of expertise in mammalian genetics and disease modeling to develop, validate and disseminate new, precise animal models of AD. In addition, the IU/JAX/PITT MODEL-AD Center contains Sage Bionetworks to provide expertise in data organization and dissemination. The IU/JAX ADPMC brings together an international, multi-disciplinary team— including geneticists and genetics technology experts, quantitative and computational biologists, clinical experts in AD and neuroimaging, pharmacologists and world leaders in the development of precision animal models of disease—that possesses the collective ability to foresee disease modeling needs as they emerge on the international stage. This will allow the IU/JAX ADPMC to serve the AD scientific community effectively and efficiently. Ultimately, this will accelerate the application of advances in animal models for the greatest possible medical benefit. The Specific Aims of the IU/JAX/PITT MODEL-AD Center are: Aim 1: Prioritize genetic variants, analyze model data, and broadly disseminate results through data sharing and online analytics. Aim 2: Creating and characterizing novel LOAD models Aim 3: Screening of novel compounds through the PTC pipeline. Aim 4: Coordinate activities within the center, the MODEL-AD consortium, and across the broader community of AD/ADRD researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $10,153,437 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	005	9	8/27/2024	SUPPLEMENT FOR EXPANSION	$397,063
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	004	9	8/12/2024	NON-COMPETING CONTINUATION	$9,833,325
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	8	4/4/2024	NON-COMPETING CONTINUATION	$0
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	8	12/6/2023	NON-COMPETING CONTINUATION	$77,440
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	8	3/12/2024	NON-COMPETING CONTINUATION	$0
2024	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	5	10/1/2023	SUPPLEMENT FOR EXPANSION	-$154,391
														Subtotal = $10,153,437

Issue Date FY: 2023 ( Subtotal = $10,197,543 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	007	8	9/12/2023	SUPPLEMENT FOR EXPANSION	$4,875
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	005	8	8/30/2023	NON-COMPETING CONTINUATION	$9,755,885
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	006	8	8/31/2023	SUPPLEMENT FOR EXPANSION	$437,250
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	004	7	8/17/2023	COMPETING CONTINUATION	$129,091
2023	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	6	8/17/2023	EXTENSION WITH OR WITHOUT FUNDS	-$129,091
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	5	3/17/2023	SUPPLEMENT FOR EXPANSION	-$37
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	5	2/2/2023	NON-COMPETING CONTINUATION	-$336
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	5	3/17/2023	NON-COMPETING CONTINUATION	-$94
														Subtotal = $10,197,543

Issue Date FY: 2022 ( Subtotal = $9,790,785 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	011	7	9/21/2022	COMPETING CONTINUATION	$9,790,785
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	009	6	3/11/2022	EXTENSION WITH OR WITHOUT FUNDS	-$5,558,915
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	004	6	2/3/2022	EXTENSION WITH OR WITHOUT FUNDS	$6,556,359
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	010	6	6/4/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	006	5	3/11/2022	SUPPLEMENT FOR EXPANSION	$406,304
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	008	5	3/11/2022	SUPPLEMENT FOR EXPANSION	$389,118
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	007	5	3/11/2022	SUPPLEMENT FOR EXPANSION	$410,930
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	5	2/3/2022	NON-COMPETING CONTINUATION	-$5,350,007
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	005	5	3/11/2022	NON-COMPETING CONTINUATION	$4,352,563
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	5	2/3/2022	SUPPLEMENT FOR EXPANSION	-$410,930
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	5	2/3/2022	SUPPLEMENT FOR EXPANSION	-$389,118
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	5	2/3/2022	SUPPLEMENT FOR EXPANSION	-$406,304
														Subtotal = $9,790,785

Issue Date FY: 2021 ( Subtotal = $5,000,000 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	6	9/14/2021	EXTENSION WITH OR WITHOUT FUNDS	$5,000,000
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	5	3/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,000,000

Issue Date FY: 2020 ( Subtotal = $8,171,665 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	005	5	8/31/2020	NON-COMPETING CONTINUATION	$6,158,485
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	004	4	8/4/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	008	5	9/9/2020	SUPPLEMENT FOR EXPANSION	$410,930
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	4	7/14/2020	SUPPLEMENT FOR EXPANSION	$410,578
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	009	5	9/9/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	4	7/17/2020	SUPPLEMENT FOR EXPANSION	$396,250
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	007	5	9/8/2020	SUPPLEMENT FOR EXPANSION	$389,118
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	006	5	9/4/2020	SUPPLEMENT FOR EXPANSION	$406,304
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	4	8/4/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	4	4/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,171,665

Issue Date FY: 2019 ( Subtotal = $6,508,146 ) (Continued on the next page)
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	007	4	8/31/2019	NON-COMPETING CONTINUATION	$5,000,000
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	3	6/12/2019	SUPPLEMENT FOR EXPANSION	$336,657
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	009	4	9/10/2019	SUPPLEMENT FOR EXPANSION	$189,547
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	008	4	9/9/2019	SUPPLEMENT FOR EXPANSION	$475,532
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	003	3	6/14/2019	SUPPLEMENT FOR EXPANSION	$283,455
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	004	3	7/16/2019	SUPPLEMENT FOR EXPANSION	$0
Grand Total All Awards = $65,992,167

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IU/JAX/PITT MODEL-AD Center: Prophylactic Treatment of Long acting GM-CSF (BBT-007) in B6.hAβsaa mice

Award Number: U54AG054345

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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