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Molecular Vector and Conditional ES Cell Clone Collection Validation and Maintenance Plan by theMMRRC at UC Davis

Award Number: U42OD012210
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Molecular Vector and Conditional ES Cell Clone Collection Validation and Maintenance Plan by theMMRRC at UC Davis - Molecular Vector and Conditional ES Cell Clone Collection Validation and Maintenance Plan by the MMRRC at UC Davis ABSTRACT This application from the Mutant Mouse Resource and Research Center at the University of California, Davis (MMRRC) proposes the validation and maintenance for distribution of data, molecular vectors, and ES cell clones for 4,867 genes targeted as knockout-first alleles produced by the EUCOMM Program. These genes are unique to the set of conditionally-targeted genes produced by KOMP2 as part of the International Mouse Phenotyping Consortium (IMPC) and are not currently available or accessible by NIH-funded researchers. Through an administrative supplement awarded last year, 2,751 vector and ES cell lines of this collection were acquired and are being transferred to the MMRRC at UC Davis. Arrangements are underway for the transfer of the balance of 2,116 over the next several months. However, full validation will be required to make the collection available for dissemination to the research community. To accomplish this goal, the MMRRC will conduct a number of quality controls steps (e.g., data verification and alignment with biological resources, concentration and purity of molecular vectors, conditional allele-specific genetic screening, cell morphology and viability in culture, chimera production and germline transmission, fecundity and viability of live offspring) to fully verify the identity and validate the utility of the vector and cell resources, produce and publish Strain Detail Sheets, integrate the collection into the MMRRC inventory, and list the collection in the online MMRRC catalog. The cost to validate and maintain this resource is a very small fraction (~2%) of what it would cost to recreate it using CRISPR-mediated gene-targeting. Once fully validated and integrated into the existing MMRRC inventory, the collection will be available for distribution to the biomedical research community upon request, especially to NIH-funded investigators who continue to express interest in conditional, lacZ tagged alleles for their research. As a result of the activities funded by this administrative supplement, expansion of the MMRRC molecular vector and conditional allele resource will exert a sustained, powerful influence on research field(s) using conditional mouse models and the overall ORIP mission to support a variety of resource and research centers that develop animal models of human biology and disease for US biomedical researchers. The costs to execute this project are beyond the available support provided by the parent MMRRC grant to UC Davis. If awarded, funds will be used to complete this project during the current grant year (ending January 31, 2026).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,890,266 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	26	8/6/2025	COMPETING CONTINUATION	$298,083
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	26	1/31/2025	COMPETING CONTINUATION	$1,095,282
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	26	8/14/2025	SUPPLEMENT FOR EXPANSION	$496,901
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	26	6/12/2025	COMPETING CONTINUATION	$1,093
2025	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	25	6/12/2025	NON-COMPETING CONTINUATION	-$1,093
														Subtotal = $1,890,266

Issue Date FY: 2024 ( Subtotal = $2,034,717 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	25	1/24/2024	NON-COMPETING CONTINUATION	$1,082,224
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	25	8/28/2024	SUPPLEMENT FOR EXPANSION	$681,936
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	25	9/10/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	25	5/14/2024	NON-COMPETING CONTINUATION	$270,557
														Subtotal = $2,034,717

Issue Date FY: 2023 ( Subtotal = $1,814,615 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	24	2/22/2023	NON-COMPETING CONTINUATION	$133,630
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	24	6/26/2023	SUPPLEMENT FOR EXPANSION	$478,325
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	24	1/19/2023	NON-COMPETING CONTINUATION	$1,202,660
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	24	8/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,814,615

Issue Date FY: 2022 ( Subtotal = $2,698,294 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	23	8/6/2022	SUPPLEMENT FOR EXPANSION	$480,835
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	23	5/5/2022	NON-COMPETING CONTINUATION	$134,915
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	23	8/8/2022	SUPPLEMENT FOR EXPANSION	$426,219
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	23	2/5/2022	NON-COMPETING CONTINUATION	$1,214,232
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	23	8/31/2022	SUPPLEMENT FOR EXPANSION	$442,093
														Subtotal = $2,698,294

Issue Date FY: 2021 ( Subtotal = $2,321,451 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	22	2/4/2021	NON-COMPETING CONTINUATION	$1,203,307
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	22	7/1/2021	SUPPLEMENT FOR EXPANSION	$498,821
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	22	8/2/2021	SUPPLEMENT FOR EXPANSION	$485,622
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	22	3/15/2021	NON-COMPETING CONTINUATION	$133,701
														Subtotal = $2,321,451

Issue Date FY: 2020 ( Subtotal = $2,680,598 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	21	8/25/2020	SUPPLEMENT FOR EXPANSION	$138,639
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	21	8/4/2020	COMPETING CONTINUATION	$324,048
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	21	2/11/2020	COMPETING CONTINUATION	$1,159,525
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	007	21	9/3/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	21	8/1/2020	SUPPLEMENT FOR EXPANSION	$1,195,115
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	21	4/22/2020	COMPETING CONTINUATION	$187,319
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	20	8/4/2020	SUPPLEMENT FOR EXPANSION	-$324,048
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	20	2/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,680,598

Issue Date FY: 2019 ( Subtotal = $1,679,955 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	20	7/27/2019	SUPPLEMENT FOR EXPANSION	$391,593
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	20	7/6/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	1/11/2019	NON-COMPETING CONTINUATION	$1,288,362
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	10/25/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,679,955

Issue Date FY: 2018 ( Subtotal = $2,177,330 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	19	6/26/2018	NON-COMPETING CONTINUATION	$128,836
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	2/2/2018	NON-COMPETING CONTINUATION	$1,159,526
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	19	8/31/2018	SUPPLEMENT FOR EXPANSION	$499,319
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	19	9/7/2018	SUPPLEMENT FOR EXPANSION	$389,649
														Subtotal = $2,177,330

Issue Date FY: 2017 ( Subtotal = $1,658,618 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	18	4/14/2017	SUPPLEMENT FOR EXPANSION	$413,756
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	18	8/28/2017	NON-COMPETING CONTINUATION	$65,518
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	18	12/22/2016	NON-COMPETING CONTINUATION	$1,179,344
														Subtotal = $1,658,618

Grand Total All Awards = $26,371,133

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Molecular Vector and Conditional ES Cell Clone Collection Validation and Maintenance Plan by theMMRRC at UC Davis

Award Number: U42OD012210

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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