Monday, June 30, 2025 6/30/2025

Mutant Mouse Resource and Research Center (MMRRC) at UC Davis

Award Number: U42OD012210
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1999
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Mutant Mouse Resource and Research Center (MMRRC) at UC Davis - ABSTRACT: Overall Section The Mutant Mouse Resource and Research Center (MMRRC) is the nation’s premier mutant mouse archive and distribution repository system. The MMRRC was established by the NIH beginning in 1999 to ensure the preservation, dissemination, and development of scientifically valuable mutant mouse strains and data generated by research scientists. Today, the MMRRC plays a key role in supporting rigor and reproducibility of experimental results using mouse models in biomedical research. The MMRRC was constituted as a trans- national consortium of four regionally-distributed Centers each hosting an archive and distribution repository, one of which is located at UC Davis (MMRRC-UCD), and an Informatics Coordination and Service Center (ICSC), also located at UC Davis. In coordination with other members of the MMRRC consortium, this grant application seeks continuing support for the MMRRC-UCD to continue to serve the needs of the nation’s biomedical research community by ensuring access to, and optimizing utilization of, transgenic, knockout and other genetically modified mutant mice and related biomaterials (germplasm, embryonic stem (ES) cells, hybridomas, mouse tissues), services, and technologies. In coordination with the other Centers, the MMRRC- UCD shall import, verify, maintain, and distribute mutant mice, gene-targeted ES cells, murine hybridoma cell lines, and germplasm of genetically unique mice that are evaluated as useful and beneficial for contemporary translational biomedical research. The MMRRC-UCD shall also adopt consortium operating principles to provide consultation, technical assistance, and genomic and other resources to assist investigators create, modify, recover, and study genetically-altered mice for applied and translational research in numerous scientific areas, including cancer, neurodegenerative, neurosensory, metabolic, musculoskeletal, reproductive, developmental, genetic, and other diseases. In addition, in response to recommendations by the EAC to the consortium, the MMRRC-UCD shall commit funding to directly to assist the ICSC with increasing submissions of and orders for new mouse models from the research community. Finally, the MMRRC-UCD has presented to and sought approval from the other Center PIs on a resource-related research project designed to develop a new, reliable, and reproducible oocyte vitrification and cryorecovery protocol for use throughout the consortium. Working within the consortium, the MMRRC-UCD will continue to develop and refine improvements to technologies that add scientific value to submitted mutant mouse strains and operations of the MMRRC consortium. In this way, the MMRRC-UCD will participate in the consortium’s goal to preserve, protect, quality control, and distribute mouse models and provide services for a modest fee upon request to research scientists and investigators across the nation and around the globe. Through surveys and feedback from our users, discussions with our MMRRC consortium colleagues and NIH Program representatives, and engagement with the MMRRC External Advisory Committee (EAC) of experts, the MMRRC-UCD shall emphasize activities to be an active and engaged member of the MMRRC consortium and to enhance services to users among the biomedical research community for years to come.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,095,282 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	26	1/31/2025	COMPETING CONTINUATION	$1,095,282
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	26	6/12/2025	COMPETING CONTINUATION	$1,093
2025	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	25	6/12/2025	NON-COMPETING CONTINUATION	-$1,093
														Subtotal = $1,095,282

Issue Date FY: 2024 ( Subtotal = $2,034,717 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	25	1/24/2024	NON-COMPETING CONTINUATION	$1,082,224
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	25	8/28/2024	SUPPLEMENT FOR EXPANSION	$681,936
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	25	5/14/2024	NON-COMPETING CONTINUATION	$270,557
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	25	9/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,034,717

Issue Date FY: 2023 ( Subtotal = $1,814,615 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	24	2/22/2023	NON-COMPETING CONTINUATION	$133,630
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	24	6/26/2023	SUPPLEMENT FOR EXPANSION	$478,325
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	24	1/19/2023	NON-COMPETING CONTINUATION	$1,202,660
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	24	8/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,814,615

Issue Date FY: 2022 ( Subtotal = $2,698,294 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	23	8/6/2022	SUPPLEMENT FOR EXPANSION	$480,835
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	23	5/5/2022	NON-COMPETING CONTINUATION	$134,915
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	23	8/8/2022	SUPPLEMENT FOR EXPANSION	$426,219
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	23	2/5/2022	NON-COMPETING CONTINUATION	$1,214,232
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	23	8/31/2022	SUPPLEMENT FOR EXPANSION	$442,093
														Subtotal = $2,698,294

Issue Date FY: 2021 ( Subtotal = $2,321,451 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	22	2/4/2021	NON-COMPETING CONTINUATION	$1,203,307
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	22	7/1/2021	SUPPLEMENT FOR EXPANSION	$498,821
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	22	8/2/2021	SUPPLEMENT FOR EXPANSION	$485,622
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	22	3/15/2021	NON-COMPETING CONTINUATION	$133,701
														Subtotal = $2,321,451

Issue Date FY: 2020 ( Subtotal = $2,680,598 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	21	8/25/2020	SUPPLEMENT FOR EXPANSION	$138,639
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	21	8/4/2020	COMPETING CONTINUATION	$324,048
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	21	2/11/2020	COMPETING CONTINUATION	$1,159,525
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	007	21	9/3/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	21	8/1/2020	SUPPLEMENT FOR EXPANSION	$1,195,115
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	21	4/22/2020	COMPETING CONTINUATION	$187,319
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	20	8/4/2020	SUPPLEMENT FOR EXPANSION	-$324,048
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	20	2/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,680,598

Issue Date FY: 2019 ( Subtotal = $1,679,955 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	20	7/27/2019	SUPPLEMENT FOR EXPANSION	$391,593
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	20	7/6/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	1/11/2019	NON-COMPETING CONTINUATION	$1,288,362
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	10/25/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,679,955

Issue Date FY: 2018 ( Subtotal = $2,177,330 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	19	6/26/2018	NON-COMPETING CONTINUATION	$128,836
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	2/2/2018	NON-COMPETING CONTINUATION	$1,159,526
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	19	8/31/2018	SUPPLEMENT FOR EXPANSION	$499,319
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	19	9/7/2018	SUPPLEMENT FOR EXPANSION	$389,649
														Subtotal = $2,177,330

Issue Date FY: 2017 ( Subtotal = $1,658,618 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	18	4/14/2017	SUPPLEMENT FOR EXPANSION	$413,756
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	18	8/28/2017	NON-COMPETING CONTINUATION	$65,518
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	18	12/22/2016	NON-COMPETING CONTINUATION	$1,179,344
														Subtotal = $1,658,618

Issue Date FY: 2016 ( Subtotal = $1,316,812 ) (Continued on the next page)
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	17	2/10/2016	NON-COMPETING CONTINUATION	$131,682
Grand Total All Awards = $25,576,149

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Mutant Mouse Resource and Research Center (MMRRC) at UC Davis

Award Number: U42OD012210

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1999

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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