Wednesday, April 24, 2024 4/24/2024

Production of Pedigreed SPF Rhesus Macaques

Award Number: U42OD010990
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Overall Abstract The CNPRC has maintained a pedigreed colony of Indian origin rhesus macaques for over 19 years. The SPF Pedigreed Indian origin rhesus colony includes both an SPF level 1 colony negative for Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV) and Simian T Cell Lymphotrophic Virus (STLV) Herpes B virus (B virus) and an SPF level 2 colony free of three additional viruses including include rhesus cytomegalovirus (RhCMV), simian foamy virus (SFV), and rhesus rhadinovirus (RRV). All colony animals have MHC typing for Mamu-A*01, Mamu-A*08, and Mamu-B*01 and the colony is managed to optimize genetic diversity. No additional animal recruitment necessary. This application will expand the percentage of SPF2 rhesus while maintaining the current overall colony size. The application proposes to evaluate the possible addition of Adeno-associated virus (AAV) and Lymphocryptovirus (LCV) to a subset of SPF2 animals and the addition of Mamu B*17 to the MHC typing panel. This application will continue to collect fecal microbiome and peripheral lymphoid cells as a biorepository for use by HIV/AIDS investigators. The four principal goals of this application are: Screen the current SPF2 colony to explore the potential for the addition of AAV and LCV to the excluded agents, or more simply for adding information about these infections to our database. Develop improved and expanded screening and confirmatory tests for detection of SPF agents to facilitate maintenance of the SPF colony. This work includes new assays for agents such as tuberculosis, which represents the first SPF agent. Evaluate addition of Mamu-B*17 to the currently tracked MHC alleles, Mamu-A*01, Mamu-A*08, and Mamu- B*01. Transition the colony pedigree analysis from the current microsatellite platform to the SNP panel and validate the proposed SNP panel with existing microsatellite data. Continue the collection and storage of microbiome and lymphocyte samples in the unique biorepository of SPF2 to facilitate future research projects investigating the interaction of HIV with the host microbiome and immune system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $953,319 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	24	2/15/2024	COMPETING CONTINUATION	$953,319
														Subtotal = $953,319

Issue Date FY: 2023 ( Subtotal = $1,484,483 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	23	1/25/2023	NON-COMPETING CONTINUATION	$1,030,214
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	23	8/10/2023	SUPPLEMENT FOR EXPANSION	$339,800
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	23	2/22/2023	NON-COMPETING CONTINUATION	$114,469
														Subtotal = $1,484,483

Issue Date FY: 2022 ( Subtotal = $1,153,561 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	22	5/5/2022	NON-COMPETING CONTINUATION	$115,357
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	22	1/20/2022	NON-COMPETING CONTINUATION	$1,038,204
														Subtotal = $1,153,561

Issue Date FY: 2021 ( Subtotal = $1,889,081 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	21	1/23/2021	NON-COMPETING CONTINUATION	$1,045,916
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	21	7/22/2021	SUPPLEMENT FOR EXPANSION	$382,900
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	21	5/7/2021	SUPPLEMENT FOR EXPANSION	$344,051
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	21	3/15/2021	NON-COMPETING CONTINUATION	$116,214
2021	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	11/23/2020	COMPETING CONTINUATION	$1,015
2021	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	11/23/2020	NON-COMPETING CONTINUATION	-$1,015
														Subtotal = $1,889,081

Issue Date FY: 2020 ( Subtotal = $1,718,212 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	20	2/6/2020	COMPETING CONTINUATION	$998,291
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	20	7/28/2020	SUPPLEMENT FOR EXPANSION	$553,538
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	20	6/25/2020	COMPETING CONTINUATION	$151,755
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	4/22/2020	COMPETING CONTINUATION	$166,383
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	19	6/25/2020	NON-COMPETING CONTINUATION	-$151,755
														Subtotal = $1,718,212

Issue Date FY: 2019 ( Subtotal = $1,109,212 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	1/11/2019	NON-COMPETING CONTINUATION	$1,109,212
														Subtotal = $1,109,212

Issue Date FY: 2018 ( Subtotal = $1,094,865 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	18	6/26/2018	NON-COMPETING CONTINUATION	$223,056
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	18	3/29/2018	NON-COMPETING CONTINUATION	$886,156
2018	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	17	2/13/2018	NON-COMPETING CONTINUATION	-$14,347
														Subtotal = $1,094,865

Issue Date FY: 2017 ( Subtotal = $1,141,203 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	17	8/28/2017	NON-COMPETING CONTINUATION	$127,032
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	17	1/24/2017	NON-COMPETING CONTINUATION	$1,014,171
														Subtotal = $1,141,203

Issue Date FY: 2016 ( Subtotal = $1,160,398 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	16	4/27/2016	COMPETING CONTINUATION	$1,160,398
														Subtotal = $1,160,398

Issue Date FY: 2015 ( Subtotal = $1,137,646 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	15	4/6/2015	NON-COMPETING CONTINUATION	$1,137,646
														Subtotal = $1,137,646

Issue Date FY: 2014 ( Subtotal = $1,149,256 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	14	4/2/2014	NON-COMPETING CONTINUATION	$1,149,256
														Subtotal = $1,149,256

Issue Date FY: 2013 ( Subtotal = $1,103,982 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Research Infrastructure Programs	000	13	4/10/2013	NON-COMPETING CONTINUATION	$1,044,778
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Research Infrastructure Programs	001	13	5/20/2013	NON-COMPETING CONTINUATION	$59,204
														Subtotal = $1,103,982

Issue Date FY: 2012 ( Subtotal = $1,160,864 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	National Center for Research Resources	000	12	3/31/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,160,864
														Subtotal = $1,160,864

Grand Total All Awards = $16,256,082

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Production of Pedigreed SPF Rhesus Macaques

Award Number: U42OD010990

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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