Wednesday, March 12, 2025 3/12/2025

Production of Pedigreed SPF Rhesus Macaques

Award Number: U42OD010990
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Overall Abstract The CNPRC has maintained a pedigreed colony of Indian-origin rhesus macaques for over 22 years. The SPF Pedigreed Indian origin rhesus colony includes both an SPF level 1 colony negative for Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV), Simian T Cell Lymphotrophic Virus (STLV) , and Herpes B virus (B virus) and an SPF Level 2 colony free of three additional viruses including rhesus cytomegalovirus (RhCMV), simian foamy virus (SFV), and rhesus rhadinovirus (RRV). This application will expand the percentage of SPF Level 2 rhesus while maintaining the current overall colony size. We will continue pedigree determination for all colony animals and characterize the Major Histocompatibility Complex (MHC) Class I (Mamu-A and -B) and Class II (Mamu-DRB, -DQA, -DQB, -DPA, and -DPB) loci in our breeding SPF rhesus macaques. This application will continue to collect fecal microbiome and peripheral blood lymphoid cells as a biorepository for use by HIV/AIDS investigators. The four principal goals of this application are: Continue to expand the SPF Level 2 population relative to Level 1 while maintaining overall colony size. Develop improved and expanded screening and confirmatory tests for the detection of SPF agents to facilitate the maintenance of the SPF colony. We will initiate annual surveillance for Trypanosoma cruzi in recognition of the expansion of the geographic range of this parasitic infection. This work includes new assays for agents such as tuberculosis, which represents the first SPF agent. Maintain genetic analysis to determine the pedigree of Indian rhesus born into the colony and test all adult breeders to characterize their Major Histocompatibility Complex (MHC) Class I (Mamu-A and -B) and Class II (Mamu-DRB, -DQA, -DQB, -DPA, and -DPB) loci. Continue the collection and storage of intestinal microbiome and peripheral blood lymphocyte samples in a unique SPF Level 2 biorepository to facilitate future research projects investigating the interaction of HIV with the host microbiome and immune system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $952,375 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	25	1/27/2025	NON-COMPETING CONTINUATION	$952,375
2025	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	24	2/21/2025	COMPETING CONTINUATION	$795,394
2025	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	23	2/21/2025	SUPPLEMENT FOR EXPANSION	-$339,800
2025	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	23	2/21/2025	NON-COMPETING CONTINUATION	-$455,594
														Subtotal = $952,375

Issue Date FY: 2024 ( Subtotal = $1,190,470 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	24	6/14/2024	COMPETING CONTINUATION	$237,151
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	24	2/15/2024	COMPETING CONTINUATION	$953,319
														Subtotal = $1,190,470

Issue Date FY: 2023 ( Subtotal = $1,484,483 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	23	1/25/2023	NON-COMPETING CONTINUATION	$1,030,214
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	23	8/10/2023	SUPPLEMENT FOR EXPANSION	$339,800
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	23	2/22/2023	NON-COMPETING CONTINUATION	$114,469
														Subtotal = $1,484,483

Issue Date FY: 2022 ( Subtotal = $1,153,561 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	22	5/5/2022	NON-COMPETING CONTINUATION	$115,357
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	22	1/20/2022	NON-COMPETING CONTINUATION	$1,038,204
														Subtotal = $1,153,561

Issue Date FY: 2021 ( Subtotal = $1,889,081 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	21	1/23/2021	NON-COMPETING CONTINUATION	$1,045,916
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	21	7/22/2021	SUPPLEMENT FOR EXPANSION	$382,900
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	21	5/7/2021	SUPPLEMENT FOR EXPANSION	$344,051
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	21	3/15/2021	NON-COMPETING CONTINUATION	$116,214
2021	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	11/23/2020	COMPETING CONTINUATION	$1,015
2021	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	11/23/2020	NON-COMPETING CONTINUATION	-$1,015
														Subtotal = $1,889,081

Issue Date FY: 2020 ( Subtotal = $1,718,212 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	20	2/6/2020	COMPETING CONTINUATION	$998,291
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	20	7/28/2020	SUPPLEMENT FOR EXPANSION	$553,538
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	20	6/25/2020	COMPETING CONTINUATION	$151,755
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	20	4/22/2020	COMPETING CONTINUATION	$166,383
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	19	6/25/2020	NON-COMPETING CONTINUATION	-$151,755
														Subtotal = $1,718,212

Issue Date FY: 2019 ( Subtotal = $1,109,212 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	19	1/11/2019	NON-COMPETING CONTINUATION	$1,109,212
														Subtotal = $1,109,212

Issue Date FY: 2018 ( Subtotal = $1,094,865 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	18	6/26/2018	NON-COMPETING CONTINUATION	$223,056
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	18	3/29/2018	NON-COMPETING CONTINUATION	$886,156
2018	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	17	2/13/2018	NON-COMPETING CONTINUATION	-$14,347
														Subtotal = $1,094,865

Issue Date FY: 2017 ( Subtotal = $1,141,203 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	17	8/28/2017	NON-COMPETING CONTINUATION	$127,032
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	17	1/24/2017	NON-COMPETING CONTINUATION	$1,014,171
														Subtotal = $1,141,203

Issue Date FY: 2016 ( Subtotal = $1,160,398 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	16	4/27/2016	COMPETING CONTINUATION	$1,160,398
														Subtotal = $1,160,398

Issue Date FY: 2015 ( Subtotal = $1,137,646 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	15	4/6/2015	NON-COMPETING CONTINUATION	$1,137,646
														Subtotal = $1,137,646

Issue Date FY: 2014 ( Subtotal = $1,149,256 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	14	4/2/2014	NON-COMPETING CONTINUATION	$1,149,256
														Subtotal = $1,149,256

Issue Date FY: 2013 ( Subtotal = $1,103,982 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Research Infrastructure Programs	000	13	4/10/2013	NON-COMPETING CONTINUATION	$1,044,778
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Research Infrastructure Programs	001	13	5/20/2013	NON-COMPETING CONTINUATION	$59,204
														Subtotal = $1,103,982

Issue Date FY: 2012 ( Subtotal = $1,160,864 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	National Center for Research Resources	000	12	3/31/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,160,864
														Subtotal = $1,160,864

Grand Total All Awards = $17,445,608

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Production of Pedigreed SPF Rhesus Macaques

Award Number: U42OD010990

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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