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Establishing the GWAS Catalog as a resource for large-scale association studies

Award Number: U41HG007823
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2014
PERIOD OF PERFORMANCE END DATE: 09/30/2022

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Establishing the GWAS Catalog as a resource for large-scale association studies - The GWAS Catalog’s objective is to summarise GWAS data acquired from scientific publications, and to give the results structure, in order to summarize research findings to a broad scientific community. The Catalog is used by a growing user community of biologists and bioinformaticians worldwide. Over the next five years, the Catalog will continue to provide the most thoroughly curated resource for human variation data, by engaging journals in data recruitment, and by allowing co-submission/data transfer from other resources like dbGAP and the EGA. In order to underpin the Catalog’s relevance, a multi-stranded approach combining data generation, infrastructure development and liaison with the Catalog’s user community will be adopted. The first Aim for the next five years is for the Catalog to continue to deliver the Catalog as a community resource with high quality content. The curation system will evolve from manual curation, towards identification of data for automated extraction and review of submitted metadata, supporting author deposition, and the development of supporting QC processes. In Aim 2, the scope of the Catalog will be broadened to include new GWAS study designs, additional associated data, and emerging technologies. The Catalog’s eligibility criteria will ensure alignment with current research and the needs of the user community, but will be monitored and re-evaluated as needed. Building on previous pilots, the focus of Aim 2 will be on the inclusion of targeted array data and other genotyping methods, such as sequencing or imputation from family members. In Aim 3, the Catalog will be delivered as a scalable and sustainable resource for the future, which will allow for an extended scope of data. The development and promotion of standard formats for GWAS study design and results will be critical to ensure an efficient process for incorporating data into the Catalog. Authors will be encouraged to submit all SNP-trait associations, irrespective of p-value: this will vastly expand the depth of data available, and the utility of the Catalog. The manual curation system will be re-developed, with process automation to increase curator efficiency. Curation resources will be allocated in order to prioritise studies with the highest utility, therefore expediting the publication of these data in the Catalog. Finally, the Catalog’s resources, interfaces, and data access will be improved for all researchers by enhancing data representation, the search functionality, data visualization and integration with data from other relevant resources. User needs will be identified through surveys, and combined with feedback from other communication routes; existing data curation processes will then be modified to improve data representation, visualization, access and versatility. The continuation of the Catalog, as the main resource for data published on diseases with complex genetic traits, is of crucial importance for the biomedical research community, as a more efficient and effective way to better understand and to prevent, or cure, diseases like cardiovascular conditions, cancer and diabetes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$88,387 )
2025	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	8	10/1/2024	NON-COMPETING CONTINUATION	-$88,387
														Subtotal = -$88,387

Issue Date FY: 2023 ( Subtotal = -$308,329 )
2023	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	8	5/10/2023	NON-COMPETING CONTINUATION	-$308,329
														Subtotal = -$308,329

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	000	8	3/22/2022	NON-COMPETING CONTINUATION	$0
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	001	8	8/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $818,640 )
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	000	8	8/11/2021	NON-COMPETING CONTINUATION	$818,640
														Subtotal = $818,640

Issue Date FY: 2020 ( Subtotal = $987,469 )
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	7	7/16/2020	NON-COMPETING CONTINUATION	$818,640
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	7	7/21/2020	SUPPLEMENT FOR EXPANSION	$168,829
2020	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	6	6/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $987,469

Issue Date FY: 2019 ( Subtotal = $866,323 )
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	6	6/14/2019	NON-COMPETING CONTINUATION	$866,323
														Subtotal = $866,323

Issue Date FY: 2018 ( Subtotal = $1,087,523 )
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	5	6/29/2018	NON-COMPETING CONTINUATION	$818,640
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	5	8/9/2018	NON-COMPETING CONTINUATION	$268,883
2018	2016	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	3	2/9/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,087,523

Issue Date FY: 2017 ( Subtotal = $818,640 )
2017	2017	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	4	9/14/2017	COMPETING CONTINUATION	$818,640
														Subtotal = $818,640

Issue Date FY: 2016 ( Subtotal = $632,776 )
2016	2016	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	3	9/19/2016	NON-COMPETING CONTINUATION	$632,776
														Subtotal = $632,776

Issue Date FY: 2015 ( Subtotal = $801,277 )
2015	2015	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	001	2	9/8/2015	NON-COMPETING CONTINUATION	$757,101
2015	2015	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	1	6/18/2015	SUPPLEMENT FOR EXPANSION	$44,176
														Subtotal = $801,277

Issue Date FY: 2014 ( Subtotal = $654,816 )
2014	2014	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Trans-NIH Research Support	001	1	9/3/2014	SUPPLEMENT FOR EXPANSION	$120,025
2014	2014	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	1	8/27/2014	NEW	$534,791
														Subtotal = $654,816

Grand Total All Awards = $6,270,748

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Establishing the GWAS Catalog as a resource for large-scale association studies

Award Number: U41HG007823

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2014

PERIOD OF PERFORMANCE END DATE: 09/30/2022

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