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UniProt: A centralized protein sequence and function resource

Award Number: U41HG007822
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2018

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UniProt: A centralized protein sequence and function resource - DESCRIPTION (provided by applicant): The long-term objective of the UniProt Consortium is to provide a centralized curated, accurate, stable, and comprehensive protein sequence and function resource by enhancing the UniProt Knowledgebase (UniProtKB) and ensuring that the diverse information in UniProt will be of use to a broad scientific user community by exploiting a range of dissemination strategies. This objective will enable new scientific discoveries in the fields of biomedical research that will enhance human health. The specific aims of the project are: 1. To provide the experimental information associated with proteins through manual curation of the scientific literature. This will be achieved by identifying and curating newly experimentally characterized proteins and by updating existing proteins for new information. Interaction with other manually curated resources will be extended, and community standard interfaces used. 2. To automatically annotate experimentally uncharacterized proteins, increasing both coverage and depth. This will enhance the value of the exponentially growing protein sequence space and allow for the correction of erroneous information. UniProt's rule based system will be made available to the community. 3. To act as the global central hub for protein information. This will be achieved by leveraging data from other resources either as imports or as links/visualization and organizing the data for its optimum use and navigation. New data types will be included as they become available, and the technical infrastructure will be developed to scale with the continued growth in protein sequences. 4. To maintain and further develop UniProt's website and other services. This will be done by creating or incorporating specialized visualizations from other resources for a more intuitive and better overview, and by providing appropriate web services and formats to facilitate the extraction of UniProt's rich data. 5. To actively seek user feedback from and provide training for existing and new user communities. Designated user experience testing and the engagement of new user communities will help to define future directions. Target research communities include researchers working on genetic variation, medical researchers and clinicians, cell biologists and drug discovery/ pharmaceutical researchers. RELEVANCE: The databases produced by the UniProt Consortium provide researchers with an integrated access to protein sequence and function by gathering and enriching data from genomics and proteomics projects as well as the results published by individual researchers. This is a crucial step in making genomics and proteomics research results easily accessible to support biomedical research in academia and industry and hence facilitate the development of preventive and curative strategies for human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$142,922 )
2018	2017	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	4	9/22/2018	SUPPLEMENT FOR EXPANSION	-$142,922
														Subtotal = -$142,922

Issue Date FY: 2017 ( Subtotal = $5,201,095 )
2017	2017	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	4	9/22/2017	SUPPLEMENT FOR EXPANSION	$213,235
2017	2017	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	4	5/30/2017	NON-COMPETING CONTINUATION	$4,987,860
														Subtotal = $5,201,095

Issue Date FY: 2016 ( Subtotal = $5,899,997 )
2016	2016	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	3	5/19/2016	NON-COMPETING CONTINUATION	$5,899,997
														Subtotal = $5,899,997

Issue Date FY: 2015 ( Subtotal = $6,143,982 )
2015	2015	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	2	5/15/2015	NON-COMPETING CONTINUATION	$5,752,498
2015	2015	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	001	2	9/15/2015	SUPPLEMENT FOR EXPANSION	$391,484
														Subtotal = $6,143,982

Issue Date FY: 2014 ( Subtotal = $4,650,000 )
2014	2014	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	1	9/17/2014	NEW	$4,650,000
														Subtotal = $4,650,000

Grand Total All Awards = $21,752,152

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UniProt: A centralized protein sequence and function resource

Award Number: U41HG007822

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2018

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