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Reactome: An Open Knowledgebase of Human Pathways

Award Number: U41HG003751
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2007
PERIOD OF PERFORMANCE END DATE: 02/28/2023

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Reactome: An Open Knowledgebase of Human Pathways - Project Summary We seek renewal of the core operating funding for the Reactome Knowledgebase of Human Biological Pathways and Processes. Reactome is a curated, open access biomolecular pathway database that can be freely used and redistributed by all members of the biological research community. It is used by clinicians, geneti- cists, genomics researchers, and molecular biologists to interpret the results of high-throughput experimental studies, by bioinformaticians seeking to develop novel algorithms for mining knowledge from genomic studies, and by systems biologists building predictive models of normal and disease variant pathways. Our curators, PhD-level scientists with backgrounds in cell and molecular biology work closely with in- dependent investigators within the community to assemble machine-readable descriptions of human biological pathways. Each pathway is extensively checked and peer-reviewed prior to publication to ensure its assertions are backed up by the primary literature, and that human molecular events inferred from orthologous ones in animal models have an auditable inference chain. Curated Reactome pathways currently cover 8930 protein- coding genes (44% of the translated portion of the genome) and ~150 RNA genes. We also offer a network of reliable ‘functional interactions’ (FIs) predicted by a conservative machine-learning approach, which covers an additional 3300 genes, for a combined coverage of roughly 60% of the known genome. Over the next five years, we will: (1) curate new macromolecular entities, clinically significant protein sequence variants and isoforms, and drug-like molecules, and the complexes these entities form, into new reac- tions; (2) supplement normal pathways with alternative pathways targeted to significant diseases and devel- opmental biology; (3) expand and automate our tools for curation, management and community annotation; (4) integrate pathway modeling technologies using probabilistic graphical models and Boolean networks for pathway and network perturbation studies; (5) develop additional compelling software interfaces directed at both computational and lab biologist users; and (6) and improve outreach to bioinformaticians, molecular bi- ologists and clinical researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$7,845 )
2024	2021	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Human Genome Research	000	14	11/8/2023	NON-COMPETING CONTINUATION	-$7,845
														Subtotal = -$7,845

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Human Genome Research	001	14	11/10/2021	NON-COMPETING CONTINUATION	$0
2022	2021	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Human Genome Research	000	14	10/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,354,555 )
2021	2021	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Human Genome Research	000	14	3/9/2021	NON-COMPETING CONTINUATION	$1,354,555
														Subtotal = $1,354,555

Issue Date FY: 2020 ( Subtotal = $2,242,732 )
2020	2020	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	001	13	9/8/2020	NON-COMPETING CONTINUATION	$0
2020	2020	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	000	13	2/19/2020	NON-COMPETING CONTINUATION	$1,932,440
2020	2020	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	002	13	9/10/2020	SUPPLEMENT FOR EXPANSION	$310,292
														Subtotal = $2,242,732

Issue Date FY: 2019 ( Subtotal = $1,938,440 )
2019	2019	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	002	12	3/14/2019	SUPPLEMENT FOR EXPANSION	$583,885
2019	2019	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	001	12	3/6/2019	NON-COMPETING CONTINUATION	$1,354,555
2019	2018	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	000	11	10/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,938,440

Issue Date FY: 2018 ( Subtotal = $1,354,554 )
2018	2018	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	000	11	2/21/2018	NON-COMPETING CONTINUATION	$1,083,642
2018	2018	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	001	11	6/15/2018	NON-COMPETING CONTINUATION	$270,912
														Subtotal = $1,354,554

Issue Date FY: 2017 ( Subtotal = $1,354,554 )
2017	2017	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	004	10	7/27/2017	COMPETING CONTINUATION	$270,910
2017	2017	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	003	10	6/12/2017	COMPETING CONTINUATION	$96,034
2017	2017	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	001	10	3/9/2017	COMPETING CONTINUATION	$1,083,644
2017	2016	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	002	9	6/12/2017	NON-COMPETING CONTINUATION	-$96,034
2017	2016	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON	M5G 0A3		CAN	Human Genome Research	000	9	3/8/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,354,554

Issue Date FY: 2016 ( Subtotal = $1,271,107 )
2016	2016	ONTARIO INSTITUTE FOR CANCER RESEARCH	101 COLLEGE STREET	TORONTO				CAN	Human Genome Research	000	9	3/2/2016	NON-COMPETING CONTINUATION	$1,271,107
														Subtotal = $1,271,107

Issue Date FY: 2015 ( Subtotal = $1,243,799 )
2015	2015	ONTARIO INSTITUTE FOR CANCER RESEARCH	101 COLLEGE STREET	TORONTO				CAN	Human Genome Research	000	8	2/4/2015	NON-COMPETING CONTINUATION	$1,243,799
														Subtotal = $1,243,799

Issue Date FY: 2014 ( Subtotal = $1,248,956 )
2014	2014	ONTARIO INSTITUTE FOR CANCER RESEARCH	101 COLLEGE STREET	TORONTO				CAN	Human Genome Research	000	7	4/22/2014	NON-COMPETING CONTINUATION	$1,248,956
														Subtotal = $1,248,956

Issue Date FY: 2013 ( Subtotal = $1,216,983 )
2013	2013	ONTARIO INSTITUTE FOR CANCER RESEARCH	101 COLLEGE ST, STE 800	TORONTO				CAN	Human Genome Research	000	6	5/14/2013	EXTENSION WITH OR WITHOUT FUNDS	$1,216,983
														Subtotal = $1,216,983

Issue Date FY: 2012 ( Subtotal = $1,300,000 )
2012	2012	ONTARIO INSTITUTE FOR CANCER RESEARCH	101 COLLEGE ST, STE 800	TORONTO				CAN	Human Genome Research	000	5	5/23/2012	COMPETING CONTINUATION	$1,300,000
														Subtotal = $1,300,000

Grand Total All Awards = $14,517,835

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Reactome: An Open Knowledgebase of Human Pathways

Award Number: U41HG003751

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2007

PERIOD OF PERFORMANCE END DATE: 02/28/2023

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