The recipient, NYC Health + Hospitals/Bellevue, in collaboration with respective departments of health, will strive to strengthen safe patient care capabilities internally, as well as enhance special pathogen preparedness across New York City, New York State, New Jersey, the US Virgin Islands, and Puerto Rico. The project aims to provide comprehensive, equitable care to patients suspected or confirmed to have special pathogen infection while keeping the healthcare workforce safe. The objectives are to (1) provide training and education to Tier A staff, (2) build a network to deliver Tier A responsibilities as detailed in the National Special Pathogen System of Care (NSPS) Strategy, (3) develop a regional CONOPs plan to strengthen patient movement across the region and (4) share resources across institutions to navigate infectious disease surges. The expected outcomes of the project are to create (1) a highly skilled and motivated workforce that can provide safe patient care as well as guidance to regional partners, (2) a cohesive, regional plan to manage patients with suspected or confirmed special pathogens that offer equitable, nimble care irrespective of geographic location, and (3) delivery of NSPS Tier A responsibilities such as resource sharing for Tiers B, C, and D. The products from this project are (1) a blueprint detailing how to successfully execute R2 Regional Emerging Special Pathogen Treatment Center (RESPTC) responsibilities and meet ASPR expectations, (2) a final report, including evaluations, detailing progress on stated deliverables, and (3) a strategic communications plan to expand NYCH+H/Bellevue’s role in regional preparedness.