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Translational center for kidney microphysiological systems to improve drug safety and efficacy

Award Number: U2CTR004867
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Translational center for kidney microphysiological systems to improve drug safety and efficacy - ABSTRACT - Overall The overall goal of the University of Washington Translational center for kidney microphysiological systems to improve drug safety and efficacy is to expand upon kidney tissue chip developmental work our team has accomplished over the past decade, in order to qualify these microphysiological systems as drug development tools for specific Contexts of Use. Despite marked recent advances in our understanding of the physiology and pathophysiology of the human kidney in health and in disease, there are relatively few drugs that are proven to be safe and effective therapies for kidney diseases. Historically, the structural, functional and physiological complexity of the kidney has contributed significantly to the high rate of failures in therapeutic drug development. The complex multicellular architecture and unusual triad of physiological processes characterized by glomerular filtration, tubular secretion and tubular reabsorption, have limited the ability of animal models to recapitulate the diversity of etiologies, mechanisms, and heterogeneous clinical manifestations of most human kidney diseases. The limitations resulting from extrapolating animal model data to human kidney diseases constitutes a major barrier to developing new therapies. Until recently there has been a lack of human in vitro models that recapitulate critical aspects of kidney function or assess reparative mechanisms in response to injury. This is in part because microfluidic flow is so essential to kidney structure and cellular function. In response to this critical unmet need, our group has pioneered the development of ‘human kidney-on-a-chip’ microphysiological systems. Our in vitro on chip models recapitulate critical aspects of kidney physiology, assess the mechanisms and response to injury, and can test reparative mechanisms, all of which can substantially enhance successful drug development that is needed to improve the lives of people living with kidney diseases


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,614,842 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	National Center for Advancing Translational Sciences	000	4	2/11/2026	NON-COMPETING CONTINUATION	$1,614,842
														Subtotal = $1,614,842

Issue Date FY: 2025 ( Subtotal = $1,612,823 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	National Center for Advancing Translational Sciences	001	3	3/12/2025	NON-COMPETING CONTINUATION	$1,451,541
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	National Center for Advancing Translational Sciences	002	3	7/26/2025	NON-COMPETING CONTINUATION	$161,282
2025	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	National Center for Advancing Translational Sciences	000	2	10/28/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $1,612,823

Issue Date FY: 2024 ( Subtotal = $1,522,442 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	National Center for Advancing Translational Sciences	002	2	9/24/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,522,442
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	National Center for Advancing Translational Sciences	001	1	9/21/2024	NEW	-$1,522,442
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	National Center for Advancing Translational Sciences	000	1	1/26/2024	NEW	$1,522,442
														Subtotal = $1,522,442

Grand Total All Awards = $4,750,107

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Translational center for kidney microphysiological systems to improve drug safety and efficacy

Award Number: U2CTR004867

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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