Vanderbilt Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes - Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Overall Center The Vanderbilt Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes (VMPMOD) is built on the strong Vanderbilt history of serving as a resource to study conscious, unstressed mice. During its 20-year lifespan the Vanderbilt Mouse Metabolic Phenotyping Center advanced research in diabetes, obesity, and metabolism by providing the scientific community with innovative and high-quality phenotyping services to study mouse models. Quality services and access to experienced faculty has created a large demand from outside investigators to use the Center. VMPMOD consists of three cores dedicated to serving outside investigators. The Administrative Core provides scientific, financial, and administrative leadership and oversees service requests and data management. The Animal Health and Welfare Core evaluate mice submitted to VMPMOD, oversees mouse health and welfare, and ensures compliance with regulatory bodies and VMPMOD guidelines. The Mouse Metabolic Physiology Core provides a range of surgical services for mice and flexible experimental services performed under customizable environment-controlled conditions. These experimental services are conducted by the Metabolic Regulation Subcore (MRSC) and the Body Weight Regulation Subcore (BWRSC). MRSC uses flexible platforms to study insulin action, hormone secretion, hypoglycemic regulation, exercise metabolism, and metabolic flux analysis with and without simultaneous measurements of ⩒O2, ⩒CO2, respiratory exchange ratio, carbohydrate oxidation, and fat oxidation. BWRSC utilizes techniques that allow for granular measurements of the components of energy balance under a wide range of conditions. Chemogenetics, optogenetics, and fiber photometry are applied in the MRSC and BWRSC to study neural control mechanisms in concurrence with studies of metabolism and energy balance. The proposed VMPMOD has made significant technical developments that create new opportunities for advances in our understanding of diabetes, obesity, and metabolism. The Vanderbilt mouse program has been successful because it is comprised of a faculty willing to develop and make technology that is part of their research lifeline available to the scientific community and because of staff that are so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them. The same faculty and staff that has made the program successful in the past will continue to lead VMPMOD. Modified Project Summary/Abstract Section Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Administrative Core The Administrative Core provides oversight of Vanderbilt Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes (VMPMOD) activities. This Core ensures that the Center operates efficiently, has a sustainable financial model, and is responsive to the needs of the national scientific community and the recommendations of standing committees. The Administrative Core supports all functions of VMPMOD which include (a) evaluation of the suitability of mice submitted for study to the Center, (b) consultation with investigators in conjunction with core staff for testing procedures on mice submitted to the Center, (c) oversight of research and development, (d) oversight of the outreach/educational component, (e) data management in conjunction with the National Program Coordinating Unit, and (f) interaction and coordinating services with other members of the consortium. This Core is also responsible for ensuring VMPMOD functions within guidelines established by Vanderbilt University School of Medicine and the Program National Steering Committee. The Administrative Core consists of the Center Director, Associate Director, Resource Statistician, and Progra
