Thursday, October 2, 2025 10/2/2025

USC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization Studies

Award Number: U2CCA252971
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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USC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization Studies - Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the US. Populations exhibiting variability in colorectal cancer outcomes, especially those experiencing higher incidence rates and early-onset CRC, require more thorough genomic characterization. Current genomic research has extensively characterized CRC but lacks sufficient representation of patients with early onset and adverse clinical outcomes. Comprehensive molecular characterization is crucial for determining whether observed clinical variations are correlated with specific genomic factors or biological pathways. To achieve significant advances in genomic characterization research, improved strategies for participant recruitment, consent, and engagement are required. Effective participant involvement in research is crucial for advancing precision medicine initiatives and ensuring robust translational biomedical research outcomes. Developing optimized methods to engage and retain research participants throughout all stages of genomic research, from initial recruitment through results dissemination, will enhance scientific validity, strengthen participant-researcher relationships, and potentially improve clinical outcomes. To address these needs, we established the USC Center for Optimization of Participant Engagement in Cancer Characterization (COPECC). This Center specializes in optimizing recruitment and retention methods for genomic research related to colorectal cancer. As part of the NCI U2C Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network, USC COPECC employs rigorous scientific methodologies for participant engagement, data collection, genomic analysis, and results dissemination. The overall objective of USC COPECC is to generate scientifically robust data and standardized engagement practices to enhance research participation and optimize outcomes in CRC genomic research across populations with different genomic profiles.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,712,500 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	5	9/10/2025	NON-COMPETING CONTINUATION	$3,712,500
														Subtotal = $3,712,500

Issue Date FY: 2024 ( Subtotal = $3,810,841 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	4	9/12/2024	NON-COMPETING CONTINUATION	$3,810,841
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	3	8/22/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	3	4/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,810,841

Issue Date FY: 2023 ( Subtotal = $1,386,086 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	3	9/18/2023	NON-COMPETING CONTINUATION	$1,386,086
														Subtotal = $1,386,086

Issue Date FY: 2022 ( Subtotal = $4,012,287 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	2	9/12/2022	NON-COMPETING CONTINUATION	$299,787
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	2	9/1/2022	NON-COMPETING CONTINUATION	$3,712,500
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	12/6/2021	NEW	$0
														Subtotal = $4,012,287

Issue Date FY: 2021 ( Subtotal = $3,712,500 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	9/22/2021	NEW	$3,712,500
														Subtotal = $3,712,500

Grand Total All Awards = $16,634,214

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USC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization Studies

Award Number: U2CCA252971

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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