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The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health

Award Number: U24OD023319
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health - Environmental exposures profoundly shape lifespan health and disease trajectories. Preconception and pre- perinatal exposure can permanently alter the developing brain and associated regulatory systems to increase susceptibility to a host of diseases and developmental challenges. Protective and promotive environmental factors can promote well-being, even amidst adversity. The ECHO Consortium of Cohort Study Sites, Cores, and Centers is dedicated to mapping the impact of early exposures on child health and development. Good science depends on good measurement. Our proposed ECHO Measurement Core will advise, orchestrate, and frame the coordinated, sensitive measurement of exposures, developmental processes, and health outcomes central to achieving ECHO's objective. We propose three aims. Aim 1 is to develop and refine measures for the ECHO Cohort Protocol (ECP), including methods to implement the measures. We will lead efforts to optimize the measurement of exposures and outcomes, mindful of best measurement practices as well as respondent and staff burden. We will lead the timely development of a preconception section for the Protocol by drawing on diverse expertise across the ECHO Network to ensure feasible, robust, and culturally sensitive assessment of critical data elements in the preconception period that have direct import for the primary ECHO child health outcomes (pre-, peri-, post-natal, airways, obesity, neurodevelopment, and positive health). We will leverage novel psychometric and technological methods such as computer adaptive tests, wearable sensors, and other innovations in remote assessment, to reduce barriers to study participation and enhance participant retention. Aim 2 is to assist the ECHO Consortium in implementing and evaluating the ECP. We will further collaborate with everyone in the Consortium to finalize the protocol and establish a standard implementation strategy that can be implemented across the diverse Cohort Study Sites, including determining optimal study visit structure and choreography, developing Manual(s) of Operating Procedures (MOPs), and creating, supporting, and, when appropriate, leading training. Aim 3 is to lead strategic decision-making and operational strategies to incorporate new and revised measures to advance ECHO Cohort science while minimizing participant and staff burden. We propose to optimize measurement decisions by maintaining collaborative communication, rapidly deploying data and biospecimen collection for time-sensitive needs, identifying and evaluating important measurement developments, creating a technology pipeline for rapid adoption of innovative approaches to data collection, and ensuring data collection strategies are validated for diverse populations. Our measurement science expertise within and outside of ECHO, paired with our participant-centered approach, enables us to bridge reliable and valid assessment with practical feasibility and ultimately allows us to bring ECHO scientists together toward our shared goal of mapping the impact of early exposures on child health and development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,353,553 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	8	7/10/2025	NON-COMPETING CONTINUATION	$874,997
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	7	1/24/2025	SUPPLEMENT FOR EXPANSION	$2,478,556
														Subtotal = $3,353,553

Issue Date FY: 2024 ( Subtotal = $5,499,986 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	004	7	9/10/2024	SUPPLEMENT FOR EXPANSION	$2,000,000
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	003	7	6/13/2024	NON-COMPETING CONTINUATION	$3,499,986
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	002	6	6/12/2024	COMPETING CONTINUATION	$49,369
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	5	6/12/2024	SUPPLEMENT FOR EXPANSION	-$6,518
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	5	6/12/2024	NON-COMPETING CONTINUATION	-$42,851
														Subtotal = $5,499,986

Issue Date FY: 2023 ( Subtotal = $3,499,985 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	6	8/30/2023	COMPETING CONTINUATION	$3,499,985
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	5	4/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,499,985

Issue Date FY: 2022 ( Subtotal = $3,391,537 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	5	8/26/2022	SUPPLEMENT FOR EXPANSION	$447,759
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	5	8/24/2022	NON-COMPETING CONTINUATION	$2,943,778
														Subtotal = $3,391,537

Issue Date FY: 2021 ( Subtotal = $3,116,788 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	4	8/25/2021	NON-COMPETING CONTINUATION	$3,116,788
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	3	6/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,116,788

Issue Date FY: 2020 ( Subtotal = $4,276,059 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	005	3	8/19/2020	SUPPLEMENT FOR EXPANSION	$157,973
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	006	3	9/10/2020	NON-COMPETING CONTINUATION	$240,783
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	004	3	8/17/2020	NON-COMPETING CONTINUATION	$3,877,303
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	003	2	4/30/2020	EXTENSION WITH OR WITHOUT FUNDS	$986
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	001	2	3/2/2020	EXTENSION WITH OR WITHOUT FUNDS	$1,521,363
2020	2016	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	002	1	4/30/2020	NEW	-$986
2020	2016	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	1	3/2/2020	NEW	-$1,521,363
														Subtotal = $4,276,059

Issue Date FY: 2019 ( Subtotal = $3,302,405 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	2	9/10/2019	EXTENSION WITH OR WITHOUT FUNDS	$3,302,405
														Subtotal = $3,302,405

Issue Date FY: 2016 ( Subtotal = $11,208,827 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Trans-NIH Research Support	000	1	9/21/2016	NEW	$11,208,827
														Subtotal = $11,208,827

Grand Total All Awards = $37,649,140

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The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health

Award Number: U24OD023319

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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