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MOSAAIC Electronic Health Records Administrative Supplement

Award Number: U24HL169645
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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MOSAAIC Electronic Health Records Administrative Supplement - Project Summary/Abstract Asian American, Native Hawaiian, and Pacific Islander (AANHPI) people make up 7.7% of the U.S. population but only 2% of participants in NHLBI-funded cohorts. MOSAAIC is a longitudinal cohort of at least 10,000 AANHPI adults established to address this gap. As in most NHLBI cohorts, MOSAAIC currently ascertains cardiovascular outcomes through participant self-report on the Health Conditions and Procedures Form, followed by staff-initiated medical record requests. This process is accurate but slow, burdensome for site staff, and prone to missed events when a participant forgets an encounter or receives care across health systems that do not share records with one another. This two-year administrative supplement tests whether a health information exchange (HIE) can serve as a more efficient and/or complementary ascertainment channel for the same outcome panel MOSAAIC already collected by self-report: acute myocardial infarction, heart failure, stroke, coronary revascularization, cause of death, atrial fibrillation, pulmonary embolism, and deep vein thrombosis. In Year 1 we will select a Clinical/Community Field Center (CCFC) and HIE vendor serving that catchment area, prepare data transfer plans, develop and translate all participant documents, obtain all necessary IRB approvals, and reconsent already-enrolled participants where required. In Year 2 we will transmit demographic files to the selected vendor, receive matching data from the HIE vendor, and evaluate match rate, completeness, and concordance between EHR-ascertained and self-reported events. Findings will give the Coordinating Center an empirical basis for deciding whether and how to extend HIE- based ascertainment to MOSAAIC's remaining CCFCs and will directly inform the MOSAAIC Outcome Ascertainment Manual of Procedures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $10,396,133 )
2026	2026	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	002	4	9/2/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2026	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	001	4	8/28/2026	SUPPLEMENT FOR EXPANSION	$199,820
2026	2026	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	000	4	8/14/2026	NON-COMPETING CONTINUATION	$10,196,313
														Subtotal = $10,396,133

Issue Date FY: 2025 ( Subtotal = $10,939,523 )
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	004	3	9/1/2025	SUPPLEMENT FOR EXPANSION	$1,586,327
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	003	3	8/12/2025	SUPPLEMENT FOR EXPANSION	$299,987
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	002	3	8/1/2025	NON-COMPETING CONTINUATION	$8,753,539
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	005	3	9/22/2025	SUPPLEMENT FOR EXPANSION	$299,670
2025	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	000	2	10/10/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	001	2	10/10/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $10,939,523

Issue Date FY: 2024 ( Subtotal = $4,983,539 )
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	002	2	9/4/2024	SUPPLEMENT FOR EXPANSION	$372,945
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	001	2	7/24/2024	NON-COMPETING CONTINUATION	$4,168,697
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	003	2	9/10/2024	SUPPLEMENT FOR EXPANSION	$441,897
2024	2023	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	000	1	6/28/2024	NEW	$0
														Subtotal = $4,983,539

Issue Date FY: 2023 ( Subtotal = $2,599,968 )
2023	2023	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cardiovascular Diseases Research	000	1	8/4/2023	NEW	$2,599,968
														Subtotal = $2,599,968

Grand Total All Awards = $28,919,163

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MOSAAIC Electronic Health Records Administrative Supplement

Award Number: U24HL169645

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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