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2/1 Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA)

Award Number: U24HL141727
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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2/1 Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA) - Core Summary/Abstract The Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA) Data Coordinating Center (DCC) will fulfill an essential need to ensure that the ARREST Pneumonia trial will achieve its mission to establish the efficacy of ancillary therapy directly targeting the lung injury that occurs with pneumonia. Critical to carrying out the trial’s success is DCC oversight of the implementation of the study design and randomization scheme, performing the interim and final data analysis, regular data and safety monitoring reports, the timely dissemination of findings, and data and resource sharing. To meet its goals, the DCC will employ open-source secure web-based tools such as REDCap for housing data across the 10 sites and allowing web-based randomization;; appropriate statistical techniques, including methods for the analysis of time-to- event data in the presence of competing risks;; and expertise in clinical trial design and data safety monitoring. The DCC includes a stellar team with extensive experience in innovative clinical trial designs, statistical modeling, managing large and complex data sets, and monitoring data quality. Importantly, the operation of the DCC will rely heavily on the philosophy that DCC members should be fully integrated into the trial’s research team as well as in the infrastructural support in order to optimally meet the trials data-related and coordination needs. To that end, the DCC is composed of five support teams corresponding to key support functions of a biostatistics and data coordinating center. The DCC’s structure will ensure the success of the scientific goals for ARREST Pneumonia by designing and monitoring the trial, developing a database in REDCap, providing specific expertise on safety monitoring and quality control, implementing analyses, and providing principal interpretation for dissemination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	001	5	6/15/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	5	5/15/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	002	5	6/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $375,969 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	5	8/23/2023	NON-COMPETING CONTINUATION	$375,969
														Subtotal = $375,969

Issue Date FY: 2022 ( Subtotal = $340,721 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	002	4	9/9/2022	NON-COMPETING CONTINUATION	$340,721
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	001	3	4/13/2022	NON-COMPETING CONTINUATION	$0
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	3	3/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $340,721

Issue Date FY: 2021 ( Subtotal = $351,676 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	3	9/2/2021	NON-COMPETING CONTINUATION	$351,676
														Subtotal = $351,676

Issue Date FY: 2020 ( Subtotal = $367,033 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	002	2	8/29/2020	NON-COMPETING CONTINUATION	$367,033
2020	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	1	2/20/2020	NEW	$0
2020	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	001	1	4/24/2020	NEW	$0
														Subtotal = $367,033

Issue Date FY: 2019 ( Subtotal = $377,990 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Lung Diseases Research	000	1	9/5/2019	NEW	$377,990
														Subtotal = $377,990

Grand Total All Awards = $1,813,389

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2/1 Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA)

Award Number: U24HL141727

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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