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Translational Research Capacity Building Initiative to Address Cardiovascular Diseases in Nepal

Award Number: U24HL136789
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2022

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Translational Research Capacity Building Initiative to Address Cardiovascular Diseases in Nepal - PROJECT SUMMARY/ABSTRACT Translational Research Capacity Building Initiative to address Cardiovascular Diseases in Nepal Cardiovascular diseases (CVDs) are the leading causes of premature death in the world with more than 80% of all CVD-related deaths occurring in low-and middle-income countries. In Nepal, CVD and their risk factors have increased alarmingly over the past decades. Although there are proven measures for prevention and appropriate management of CVD, the challenges of implementing known interventions are severely limited by gaps in: a) epidemiological understanding of CVD and its risk factors; b) national level policies and strategies to address them; c) health systems infrastructure to provide education and treatment; d) community and patient-level support at the local level; and e) human resources to lead and implement agendas when they are developed. To address these gaps, this proposed project plans to build national capacity in Nepal to lead transnational research in cardiovascular disease (CVD) by creating and training a multi-sectorial, multi- disciplinary team; building partnership with the US and regional institutions; systematically assessing national needs; and developing an actionable translational research plan. Specific aims are to: 1) Create a multi- sectorial, multidisciplinary collaborative team to lead the translational research capacity building initiative to prevent and manage CVD in Nepal; 2) Assess national level infrastructure and capacity to implement evidence based CVD prevention and management interventions and its risk factors in Nepal; 3) Identify and prioritize health issues for cardiovascular disease in Nepal; 4) Prepare a comprehensive actionable translational research plan for management of CVD in Nepal. We will consolidate existing partnerships with US Universities (University of Washington, University of Wisconsin, Faculties from Harvard University) and build new partnerships with regional institutions (Public Health Foundation of India, Sun-Yat-Sen University in China) to support these efforts. We will apply mixed methods (qualitative and quantitative) to assess the existing capacity, needs, opportunities and challenges among the governmental and non-governmental sectors to implement evidence-based interventions for prevention and management of CVD. We will conduct secondary data analysis on epidemiology of CVD by using data sources from national surveys, hospital-based data and published and unpublished research to identify the epidemiology of CVD in the context of region, gender, ethnicity, and income groups of Nepal. We will initiate efforts to ascertain MI and stroke via a pilot registry. By the end of the project, we will have developed a critical mass of human resources in Nepal, collaborating with national and international partners to conduct translational research in CVD. We will have defined clearly identified prioritized needs and a well-defined implementation research plan to address one or more major CVD risk factors and outcomes. The team will thus form a ‘Center of Excellence for Translational Research in Cardiovascular Diseases’, which will also serve as a model for other resource-constrained settings around the world.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL CENTER	DHULIKHEL				NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	4	9/7/2023	NON-COMPETING CONTINUATION	$0
2023	2020	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL CENTER	DHULIKHEL				NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	8/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	11/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $139,266 )
2020	2020	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	5/28/2020	NON-COMPETING CONTINUATION	$139,266
														Subtotal = $139,266

Issue Date FY: 2019 ( Subtotal = $170,046 )
2019	2019	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	3	7/24/2019	NON-COMPETING CONTINUATION	$148,446
2019	2018	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	2	7/20/2019	NON-COMPETING CONTINUATION	$10,800
2019	2017	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	7/20/2019	NEW	$10,800
														Subtotal = $170,046

Issue Date FY: 2018 ( Subtotal = $137,646 )
2018	2018	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	2	8/6/2018	NON-COMPETING CONTINUATION	$0
2018	2018	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	6/8/2018	NON-COMPETING CONTINUATION	$137,646
														Subtotal = $137,646

Issue Date FY: 2017 ( Subtotal = $138,240 )
2017	2017	DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL	DHULIKHEL, DHULIKHEL	KATHMANDU	KATHMANDU			NPL	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	8/31/2017	NEW	$138,240
														Subtotal = $138,240

Grand Total All Awards = $585,198

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Translational Research Capacity Building Initiative to Address Cardiovascular Diseases in Nepal

Award Number: U24HL136789

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2022

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