Sunday, June 29, 2025 6/29/2025

Gene Ontology Consortium and Knowledgebase

Award Number: U24HG012212
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Gene Ontology Consortium and Knowledgebase - Project Summary/Abstract Because of the staggering complexity of biological systems, biomedical research is becoming increasingly dependent on knowledge stored in a computable form. The Gene Ontology (GO) is by far the largest knowledgebase of how genes function, and has become a critical component of the computational infrastructure enabling the genomic revolution. The GO knowledgebase encodes a computational model of biological systems using modern semantic technologies, and this is the key to its broad adoption and application. It stores vastly more knowledge than one person can know, and therefore enables computational analyses that would otherwise be impossible. It has become indispensable in the interpretation of large-scale molecular measurements in biological research. Crucially for human health research, GO is also one of a suite of complementary ontologies constructed in such a way to maximally promote interoperability and comparability of data sets. It represents the gene functions and biological processes that can be perturbed in human disease, helping researchers or clinicians to identify genetic contributions to disease. GO is a knowledgebase that can be statistically mined, either standalone or in combination with data from other knowledge resources, which enables researchers to discover connections and form new hypotheses from the biological networks GO represents. All knowledge in GO is represented using semantic web technologies and so is amenable to computational integration and consistency checking. To ensure the knowledge environment meets the requirements of biomedical researchers, we will: 1) Develop and refine the Gene Ontology to reflect current biological knowledge; 2) Coordinate, integrate, and provide GO assertions from multiple sources; 3) Enhance usability of the GO resources for multiple research communities. We will extend the reach of our Consortium of contributors, to efficiently expand the content of the knowledgebase, and develop test sets and challenges to spur the development of machine learning methods for knowledge capture. Our aims reflect the essential requirements for realizing the overarching objectives for a biomedical knowledgebase: efficiently capturing and integrating biological knowledge and adhering to the highest possible standard for accuracy and detail; constructing and providing a robust, flexible, powerful, and extensible technological infrastructure available not only for internal use but just as easily by the wider community; and lastly, leveraging state-of-the-art social media, web services and other technologies to disseminate the GO resource to the entire biomedical research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,283,664 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Human Genome Research	000	4	4/1/2025	NON-COMPETING CONTINUATION	$2,055,299
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Human Genome Research	001	4	4/29/2025	NON-COMPETING CONTINUATION	$228,365
														Subtotal = $2,283,664

Issue Date FY: 2024 ( Subtotal = $2,283,662 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Human Genome Research	002	3	6/7/2024	NON-COMPETING CONTINUATION	$186,422
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Human Genome Research	001	3	3/21/2024	NON-COMPETING CONTINUATION	$2,097,240
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Human Genome Research	000	2	2/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,283,662

Issue Date FY: 2023 ( Subtotal = $2,330,267 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Human Genome Research	000	2	4/7/2023	NON-COMPETING CONTINUATION	$2,330,267
														Subtotal = $2,330,267

Issue Date FY: 2022 ( Subtotal = $2,603,881 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Human Genome Research	000	1	5/31/2022	NEW	$2,603,881
														Subtotal = $2,603,881

Grand Total All Awards = $9,501,474

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Gene Ontology Consortium and Knowledgebase

Award Number: U24HG012212

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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