Thursday, July 31, 2025 7/31/2025

Expanding the AnVIL (Analysis, Visualization, and Informatics Lab-space)

Award Number: U24HG010263
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Expanding the AnVIL (Analysis, Visualization, and Informatics Lab-space) - The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) powers the next generation of computational genomic research. The AnVIL makes available several of the the most widely used analysis environments for genomics and biomedical research including Bioconductor, RStudio, Galaxy, Jupyter, Cromwell, and IGV in a secure, scalable, and accessible cloud-based environment. It currently houses >600,000 genomic samples from the largest NHGRI projects including the Centers for Common Disease Genomics (CCDG), the Centers for Mendelian Disease Genomics (CMG), the Telomere-to-Telomere (T2T) consortium, and the Genotype Tissue Expression (GTEx) project. Our user centered solution for data access, analysis, and visualization enables investigators across all levels of expertise to fully utilize genomic datasets using environments they are already familiar with, leveraging well engineered and optimized scientific computing infrastructure for greater efficiency and lower costs. In this second phase of the AnVIL, we will expand the AnVIL experience with several additional high-value services and capabilities with the goal of expanding the number of researchers using the platform and the depth of their research. In Aim 1, we will enhance the core platform in several innovative ways. First to support researchers transitioning into the cloud environment, we will work to simplify and optimize the research environment with new dashboards for monitoring costs and managing teams, along with optimizations to the APIs to run in a multi-cloud environment. Next we will optimize Galaxy in AnVIL to improve the user experience, enable cost-efficient computing, develop a workflow recommender system, and enable interoperability by integrating computing services across multiple clouds. Within Bioconductor, we will introduce new capabilities for reliable software engineering practices, enhance accessibility through monographs, curriculum authoring, and shiny apps; and optimize Bioconductor infrastructure and development for the cloud. Additionally, we will design and implement standards to ensure AnVIL is interoperable with other cloud-based research systems. In Aim 2, we will introduce four new scientific services to support critical analysis tasks. This includes services for enhanced machine learning capabilities, data harmonization and metadata autocompletion, new liftover services to translate genomic knowledge between reference genomes, and comprehensive variant discovery and analysis using long read sequencing. In Aim 3, we will expand our efforts for training and outreach. This will begin with focused high-impact events including community workshops and the AnVIL Champions Program, with the goal of seeding and developing community-driven support. We will also create scalable accessible videos and massive open online courses (MOOCs) leveraging new educational infrastructure we are developing. In Aim 4, we will continue our joint leadership with our AnVIL partners at the Broad, as well as welcome our new partners in the forthcoming AnVIL Clinical Resource (ACR) program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,940,001 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	8	5/7/2025	NON-COMPETING CONTINUATION	$2,940,001
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	7	2/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,940,001

Issue Date FY: 2024 ( Subtotal = $2,940,000 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	003	7	5/2/2024	NON-COMPETING CONTINUATION	$2,700,000
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	004	7	7/29/2024	NON-COMPETING CONTINUATION	$240,000
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	6	12/28/2023	COMPETING CONTINUATION	$0
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	6	4/9/2024	COMPETING CONTINUATION	$1,567
2024	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	5	4/9/2024	NON-COMPETING CONTINUATION	-$1,567
														Subtotal = $2,940,000

Issue Date FY: 2023 ( Subtotal = $3,088,142 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	6	7/21/2023	COMPETING CONTINUATION	$3,088,142
2023	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	5	2/22/2023	NON-COMPETING CONTINUATION	$0
2023	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	5	10/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,088,142

Issue Date FY: 2022 ( Subtotal = $2,000,000 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	5	7/22/2022	NON-COMPETING CONTINUATION	$2,000,000
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	4	5/2/2022	NON-COMPETING CONTINUATION	$0
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	4	5/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,000,000

Issue Date FY: 2021 ( Subtotal = $2,645,000 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	4	8/24/2021	SUPPLEMENT FOR EXPANSION	$645,000
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	4	7/14/2021	NON-COMPETING CONTINUATION	$2,000,000
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	3	6/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,645,000

Issue Date FY: 2020 ( Subtotal = $2,399,999 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	003	3	8/21/2020	SUPPLEMENT FOR EXPANSION	$399,999
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	3	8/10/2020	NON-COMPETING CONTINUATION	$2,000,000
2020	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	2	5/28/2020	NON-COMPETING CONTINUATION	$0
2020	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	2	5/5/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,399,999

Issue Date FY: 2019 ( Subtotal = $2,402,384 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	002	2	7/8/2019	NON-COMPETING CONTINUATION	$2,402,384
2019	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	1	11/12/2018	NEW	$0
2019	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	001	1	5/1/2019	NEW	$0
														Subtotal = $2,402,384

Issue Date FY: 2018 ( Subtotal = $2,402,384 )
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	1	9/21/2018	NEW	$2,402,384
														Subtotal = $2,402,384

Grand Total All Awards = $20,817,910

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Expanding the AnVIL (Analysis, Visualization, and Informatics Lab-space)

Award Number: U24HG010263

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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