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UniProt: A Protein Sequence and Function Resource for Biomedical Science

Award Number: U24HG007822
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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UniProt: A Protein Sequence and Function Resource for Biomedical Science - PROJECT SUMMARY/ABSTRACT This project continues the development of the UniProt Knowledgebase, which aims to provide the scientific community with a comprehensive, high-quality, and freely accessible resource of protein sequences and functional information. Proteins are an essential bridge between human genetics, the environment and phenotype. While human genetics has increasing power to find correlations between genotype and phenotype, knowledge of how proteins function, provided by UniProt, is essential for the mechanistic understanding critical to develop health outcomes through improved and personalized diagnostics, prognostics, and treatments. Biomedical research is being revolutionized by methods from the field of Artificial Intelligence, particularly Machine Learning (ML) approaches such as Deep Learning (DL). These approaches now outstrip the ability of humans in many fields and are state-of-the-art when sufficient data is available. UniProt provides gold standard training data for hundreds of ML applications in biomedical research. The work in this proposal will enhance the readiness of UniProt for use in ML and will integrate ML methods to enhance our efficiency. UniProt curators extract and synthesize experimental knowledge of proteins from papers in human and machine- readable forms using a range of standard ontologies. This proposal will further structure protein knowledge in UniProt, developing complete, machine-readable catalogs of the functional impact of human variation and of human protein networks and complexes, essential to understanding human disease. Efficiency of curation will be improved using DL models, developed in collaboration with text mining experts, to automate the identification of relevant papers and accelerate extraction of knowledge. This extracted knowledge will be validated by our expert curators and also the wider research community who will be actively engaged to further scale curation. ML approaches will also be used to infer annotations for proteins with no experimental characterization, using community challenges to develop faster, more accurate, scalable approaches to annotate the deluge of uncharacterized proteins. UniProt is an exemplar FAIR resource and has served the scientific community with metronomic data releases despite an exponential growth in data volumes. Streamlined production processes will scale efficiently and sustainably with both the growing data volume and complexity. We will explore novel technologies to ensure the continued timely release of data to the community according to the FAIR principles. UniProt is an international hub of protein data that serves hundreds of thousands of users annually. We will continue using user-centric approaches to develop the UniProt website in response to user needs and new data types. We will engage with our stakeholders and collaborators by introducing an annual strategic partnership meeting. We will engage our communities through webinars, social media, hackathons and attendance at scientific meetings to broaden the efficient and impactful use of our data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	11	12/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $5,682,070 )
2024	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	001	11	8/12/2024	SUPPLEMENT FOR EXPANSION	$324,090
2024	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	11	7/18/2024	NON-COMPETING CONTINUATION	$5,357,980
														Subtotal = $5,682,070

Issue Date FY: 2023 ( Subtotal = $5,934,121 )
2023	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	10	6/2/2023	NON-COMPETING CONTINUATION	$5,934,121
														Subtotal = $5,934,121

Issue Date FY: 2022 ( Subtotal = $6,399,655 )
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	006	9	8/2/2022	SUPPLEMENT FOR EXPANSION	$250,980
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	005	9	8/1/2022	SUPPLEMENT FOR EXPANSION	$198,000
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	003	9	7/12/2022	NON-COMPETING CONTINUATION	$5,690,000
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	004	9	7/21/2022	NON-COMPETING CONTINUATION	$260,675
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	002	8	3/23/2022	COMPETING CONTINUATION	$0
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	000	8	2/16/2022	COMPETING CONTINUATION	$64,665
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	001	7	2/16/2022	SUPPLEMENT FOR EXPANSION	-$64,665
														Subtotal = $6,399,655

Issue Date FY: 2021 ( Subtotal = $5,750,000 )
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	002	7	5/13/2021	SUPPLEMENT FOR EXPANSION	$1,916,827
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	006	8	9/22/2021	COMPETING CONTINUATION	$783,173
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	005	8	9/17/2021	COMPETING CONTINUATION	$3,050,000
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	004	7	9/16/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	001	7	5/13/2021	NON-COMPETING CONTINUATION	$0
2021	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	003	7	9/15/2021	NON-COMPETING CONTINUATION	$0
2021	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	000	7	4/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,750,000

Issue Date FY: 2020 ( Subtotal = $6,058,651 )
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	7	6/30/2020	SUPPLEMENT FOR EXPANSION	$318,651
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	7	6/24/2020	NON-COMPETING CONTINUATION	$5,740,000
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	004	7	9/16/2020	NON-COMPETING CONTINUATION	$0
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	003	7	9/15/2020	NON-COMPETING CONTINUATION	$0
2020	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	6	4/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,058,651

Issue Date FY: 2019 ( Subtotal = $6,369,881 )
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	6	8/29/2019	NON-COMPETING CONTINUATION	$400,000
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	004	6	9/24/2019	SUPPLEMENT FOR EXPANSION	$13,980
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	003	6	9/20/2019	SUPPLEMENT FOR EXPANSION	$453,902
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	6	6/7/2019	NON-COMPETING CONTINUATION	$5,434,500
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	5	2/14/2019	SUPPLEMENT FOR EXPANSION	$67,499
														Subtotal = $6,369,881

Issue Date FY: 2018 ( Subtotal = $6,555,617 )
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	5	5/31/2018	COMPETING CONTINUATION	$5,487,001
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	004	5	9/22/2018	COMPETING CONTINUATION	$142,922
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	003	5	9/6/2018	SUPPLEMENT FOR EXPANSION	$512,695
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	5	9/6/2018	COMPETING CONTINUATION	$0
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	5	8/22/2018	COMPETING CONTINUATION	$412,999
														Subtotal = $6,555,617

Grand Total All Awards = $42,749,995

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UniProt: A Protein Sequence and Function Resource for Biomedical Science

Award Number: U24HG007822

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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