The mission of the Universal Protein Resource (UniProt) is to support biomedical
research by providing a freely available, stable, comprehensive, richly and accurately
annotated protein sequence knowledgebase (www.uniprot.org). UniProt integrates,
interprets and standardizes data from a multitude of sources to achieve the most
comprehensive catalog of protein sequences and functional annotation available to
date, providing information from hundreds of thousands of publications for tens of
millions of proteins from tens of thousands of species. The activities proposed here will
increase the utility of UniProt for biomedical research and precision medicine.
The expert curated functional information provided by UniProt is widely acknowledged
to be of exceptional quality and is continuously updated as new knowledge becomes
available. Our first aim will be to continue to curate the scientific literature to ensure
UniProt remains up to date. We will also work with the text-mining community to
continue to improve curation efficiency.
The curated records (0.5 million) are complemented by the (80 million) records for
uncharacterized proteins. To ensure their usefulness for the community we will continue
to develop our automatic annotation systems to annotate these proteins based on the
knowledge of characterized proteins.
Our third aim is to connect to and integrate protein data from resources around the
world to make UniProt the worldwide global hub of protein information. The integration
of clinical variation data as well as metabolomics information with proteins will help to
support the multi-omics approaches of precision medicine.
Our fourth aim describes the production of the resource to ensure that our data is freely
available according to the FAIR principles. UniProt forms a foundation for hundreds of
life sciences data resources. Continuous software development is needed to ensure
delivery of this key component of the life science infrastructure.
The UniProt website is used by hundreds of thousands of scientists every month. The
final aim describes how we will enable this community to make best use of UniProt,
through user training, outreach and improved user interfaces, driven by user testing.