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H3ABioNet: informatics solutions for H3Africa

Award Number: U24HG006941
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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H3ABioNet: informatics solutions for H3Africa - H3ABioNet Project Summary H3ABioNet, a pan African bioinformatics network for H3Africa, had the enormous task of building bioinformatics capacity for genomics research against a backdrop of high disease burden, limited resources, poor internet and a large gap in bioinformatics skills in Africa. Despite these challenges, the network achieved a number of successes by building computing infrastructure and associated skills, developing and facilitating access to analysis tools, and implementing a comprehensive training programme. In the next phase, H3ABioNet will extend these activities more broadly to develop a robust and innovative informatics network that addresses the complex needs of genomics researchers from clinical and biological data collection to genomic data generation and analysis and ultimately to impactful translation health research. The network will be the H3Africa data coordinating centre, hosting the data prior to submission to public repositories and providing access to data in line with the needs and consent of PIs and participants. It will ensure that data is quality controlled, standardized and interoperable. In order to facilitate adequate exploitation of genomic data, H3ABioNet will improve the user experience with genomics tools, adapting them, where necessary, for African data. The network will also go beyond this by seeking innovative data integration and translational solutions to enable comprehensive systems level analysis of diseases to ensure African scientists not only remain internationally competitive, but lead the way in translational research with tangible benefits for patients. The informatics infrastructure will be implemented through eight work packages: 1) Health Informatics; 2) Data and standards; 3) Databases and resources; 4) Pipelines and Computing; 5) Tool Development; 6) Integration; 7) Training; and 8) Sustainability, Outreach and Development. A ninth, cross-cutting activity, will be H3Africa project and Coordinating Center support in data analysis and the use of the infrastructure developed. H3ABioNet will reach out to all members of the H3Africa consortium and beyond to ensure maximum utilization of our resources and to transfer skills across the continent. It will develop the next generation of African scientists who have multidisciplinary skills and the capacity to successfully attract research funding. Links with national and international organisations and networks will ensure that these scientists remain on the cutting edge of genomics and are well placed for future realisation of precision medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$255,598 )
2025	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	Trans-NIH Research Support	000	10	11/1/2024	NON-COMPETING CONTINUATION	-$255,598
														Subtotal = -$255,598

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Trans-NIH Research Support	000	10	12/21/2022	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	Trans-NIH Research Support	001	10	7/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Trans-NIH Research Support	000	10	1/6/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Trans-NIH Research Support	001	10	9/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,454,342 )
2021	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Trans-NIH Research Support	000	10	8/6/2021	NON-COMPETING CONTINUATION	$2,454,342
														Subtotal = $2,454,342

Issue Date FY: 2020 ( Subtotal = $2,500,000 )
2020	2020	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Trans-NIH Research Support	001	9	7/15/2020	NON-COMPETING CONTINUATION	$2,500,000
2020	2019	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	000	8	3/18/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,500,000

Issue Date FY: 2019 ( Subtotal = $2,429,000 )
2019	2019	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	001	8	7/5/2019	NON-COMPETING CONTINUATION	$2,429,000
2019	2019	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	002	8	8/5/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	000	7	12/12/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,429,000

Issue Date FY: 2018 ( Subtotal = $6,183,382 )
2018	2018	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	001	7	7/23/2018	NON-COMPETING CONTINUATION	$2,731,120
2018	2018	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	003	7	9/25/2018	NON-COMPETING CONTINUATION	$0
2018	2017	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	000	6	2/9/2018	COMPETING CONTINUATION	$5,628,699
2018	2017	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	002	6	9/14/2018	COMPETING CONTINUATION	-$2,176,437
														Subtotal = $6,183,382

Issue Date FY: 2017 ( Subtotal = $2,752,071 )
2017	2017	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	001	6	9/21/2017	SUPPLEMENT FOR EXPANSION	$248,400
2017	2017	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Human Genome Research	000	6	9/18/2017	COMPETING CONTINUATION	$2,503,671
														Subtotal = $2,752,071

Grand Total All Awards = $16,063,197

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H3ABioNet: informatics solutions for H3Africa

Award Number: U24HG006941

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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