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Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome

Award Number: U24HG000330
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY As the cost of genome-scale sequencing continues to decrease and new technologies for genome editing become widely adopted, the laboratory mouse is more important than ever as a model system for understanding the biological significance of human genetic variation and for advancing the emergence of genomic medicine. The Mouse Genome Database (MGD) has a unique and strategic role as a community resource for facilitating the use of the laboratory mouse for understanding genomics underlying human biology and disease. MGD serves three major user communities: (i) biomedical researchers who use mouse experimentation to investigate genetic and molecular principles of biology and disease processes, (ii) translational scientists who use the laboratory mouse to model human disease, and (iii) bioinformaticians/ computational biologists who use the rich integrated data MGD provides to develop algorithms and bioinformatics tools for data analysis and interpretation. During the project period, we will continue to curate and integrate new genetic, genomic, variant, functional, phenotypic, and human disease model data essential to researchers using the laboratory mouse in biomedical research. We will make these data freely available through a variety of web-based and programmatic user interfaces. Our core aims include: (i) maintaining the canonical catalog of mouse genome features, (ii) serving as the authoritative data for mouse functional annotations, and (iii) maintaining a comprehensive catalog of mouse mutations and strains and their phenotype and disease model associations. To support our aims, we will maintain cost-effective software, database, and hardware using industry best practices. We will maintain MGD's secure infrastructure through regular maintenance, upgrades, and planned evolution. We will leverage existing software components from the Alliance of Genome Resources and other resources where possible and focus our software development activities on unique infrastructure needed to support our core aims. To ensure the greatest impact of MGD in the broader scientific community, we will provide robust user support and outreach through online user documentation, tutorials, training workshops, and one-on-one assistance using a variety of communication modalities and major social media tools. We will actively solicit community input, data submissions, and collaborations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	36	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,488,940 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	36	5/22/2024	NON-COMPETING CONTINUATION	$203,178
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	36	1/9/2024	NON-COMPETING CONTINUATION	$2,285,762
														Subtotal = $2,488,940

Issue Date FY: 2023 ( Subtotal = $2,439,294 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	003	35	7/14/2023	NON-COMPETING CONTINUATION	$0
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	35	2/16/2023	NON-COMPETING CONTINUATION	$243,928
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	35	1/27/2023	NON-COMPETING CONTINUATION	$2,195,366
2023	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	34	10/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,439,294

Issue Date FY: 2022 ( Subtotal = $2,927,152 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	34	5/2/2022	NON-COMPETING CONTINUATION	$292,715
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	34	2/10/2022	NON-COMPETING CONTINUATION	$2,634,437
														Subtotal = $2,927,152

Issue Date FY: 2021 ( Subtotal = $4,246,734 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	33	3/19/2021	COMPETING CONTINUATION	$3,415,011
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	33	8/26/2021	COMPETING CONTINUATION	$831,723
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	33	9/24/2021	COMPETING CONTINUATION	$0
														Subtotal = $4,246,734

Grand Total All Awards = $12,102,120

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Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome

Award Number: U24HG000330

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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