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Mouse Genome Database (MGD): a core knowledge resource for functional characterization of the human genome

Award Number: U24HG000330
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/1997
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Mouse Genome Database (MGD): a core knowledge resource for functional characterization of the human genome - PROJECT SUMMARY The laboratory mouse is an essential animal model for investigating the biological significance of human genetic variation. The Mouse Genome Database (MGD) has a unique and strategic role as a FAIR-compliant community knowledgebase for facilitating the use of the laboratory mouse to investigate the genetics and genomics underlying human biology and disease. MGD serves three major user communities: (i) biomedical researchers who use mouse experimentation to investigate genetic and molecular principles of biology and disease processes, (ii) translational scientists who use the laboratory mouse to model human disease, and (iii) bioinformaticians/ computational biologists who use the rich integrated data MGD provides to develop algorithms and bioinformatics tools for data analysis and interpretation. During the project period, we will continue curating and integrating published and submitted genetic, genomic, variant, functional, phenotypic, and human disease model data essential to researchers using the laboratory mouse in biomedical research. We will make these data freely available through web-based and programmatic user interfaces. Our core aims include: (i) maintaining the canonical catalog of mouse genome features, (ii) serving as the authoritative data for mouse functional annotations, and (iii) maintaining a comprehensive catalog of mouse mutations and strains and their phenotype and disease model associations. To support our aims, we will maintain our core information systems using cost-effective industry best practices while also continuing the work needed to address the NHGRI mandate to transition MGD's curation infrastructure and user interfaces into the knowledge commons platform developed for comparative genomics by the Alliance of Genome Resources. To ensure the greatest impact of MGD in the broad biomedical research community, we will support our diverse user communities through online user documentation, video tutorials, hands-on workshops (in person and virtual), and one-on-one assistance using a variety of communication modalities and major social media outlets. We will actively solicit community input, data submissions, and collaborations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $6,720,141 )
2026	2026	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	004	38	8/17/2026	COMPETING CONTINUATION	$0
2026	2026	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	38	6/25/2026	COMPETING CONTINUATION	$6,720,141
2026	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	37	5/26/2026	NON-COMPETING CONTINUATION	$0
2026	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	37	6/22/2026	TERMINATION	$0
2026	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	003	37	7/9/2026	TERMINATION	$0
														Subtotal = $6,720,141

Issue Date FY: 2025 ( Subtotal = $2,488,941 )
2025	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	37	4/24/2025	NON-COMPETING CONTINUATION	$248,893
2025	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	37	2/13/2025	NON-COMPETING CONTINUATION	$2,240,048
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	36	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,488,941

Issue Date FY: 2024 ( Subtotal = $2,488,940 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	36	1/9/2024	NON-COMPETING CONTINUATION	$2,285,762
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	36	5/22/2024	NON-COMPETING CONTINUATION	$203,178
														Subtotal = $2,488,940

Issue Date FY: 2023 ( Subtotal = $2,439,294 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	35	1/27/2023	NON-COMPETING CONTINUATION	$2,195,366
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	003	35	7/14/2023	NON-COMPETING CONTINUATION	$0
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	35	2/16/2023	NON-COMPETING CONTINUATION	$243,928
2023	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	34	10/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,439,294

Issue Date FY: 2022 ( Subtotal = $2,927,152 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	34	5/2/2022	NON-COMPETING CONTINUATION	$292,715
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	34	2/10/2022	NON-COMPETING CONTINUATION	$2,634,437
														Subtotal = $2,927,152

Issue Date FY: 2021 ( Subtotal = $4,246,734 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	002	33	9/24/2021	COMPETING CONTINUATION	$0
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	001	33	8/26/2021	COMPETING CONTINUATION	$831,723
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Human Genome Research	000	33	3/19/2021	COMPETING CONTINUATION	$3,415,011
														Subtotal = $4,246,734

Grand Total All Awards = $21,311,202

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Mouse Genome Database (MGD): a core knowledge resource for functional characterization of the human genome

Award Number: U24HG000330

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/1997

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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