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Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project

Award Number: U24HD106537
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project - Program Director/Principal Investigator (Bell, Thomas, J.): Project Summary: Accelerating scientific discoveries across the entire spectrum of pediatric research requires advancing our current understanding of the unique molecular profiles and physiologies in all healthy tissues across the human body. The developmental Genotype-Tissue Expression (dGTEx) project will establish the first comprehensive public resource correlating gene expression and genetic variation in pediatric tissues from all major organ systems in the human body. This project will identify the molecular profiles in ~30 distinct tissue types from four developmental groups: Early post-natal, Early childhood, Pre-pubertal, and Post-pubertal. dGTEx will capitalize on new emerging methodologies to capture detailed evaluations on the developing brain and include options for single cell analysis on multiple tissues. To advance our understanding of the Ethical, Legal, Social Implications (ELSI) in pediatric tissue donation, dGTEx also includes an ELSI study to analyze these factors. The data from dGTEx will provide an unrivaled research resource for clinicians and scientists to gain new insights on the molecular milestones of regulatory processes that direct the development of healthy tissues. To support the advancement of dGTEx, this proposal will establish the pediatric Biospecimen Procurement Center (BPC) to provide the pediatric Laboratory Data Analysis Collection Center (LDACC) with suitable tissue samples for their analysis. Our proposal includes a multi-institutional effort with extensive expertise in pediatric recoveries, research, pathology, imaging, biobanking, brain research, and cutting-edge molecular techniques, such as single cell analysis. The objectives for our BPC recovery team will be led by a collaborative effort amongst: 1) National Disease Research Interchange (NDRI) to provide project management and coordinate the recovery collection effort from a network of TSS, 2) Children's Hospital of Philadelphia (CHOP) to process, store, and coordinate pathological review of all non-brain tissues and manage the bioinformatics workflow, and 3) NeuroBiobank at University of Maryland (NBB-Maryland) to process, store, and provide pathological review of brains. This breadth of expertise is essential for the BPC to provide well-annotated, suitable biospecimens to enable reliable and reproducible results from the LDACC's cutting-edge experimental methods and rigorous data interpretations. Improving our understanding of ELSI-specific challenges in pediatric tissue donation is an unmet need for the research community. To enable a more complete analysis of these challenges, Johns Hopkins All Children's Hospital (JHACH) will coordinate the dGTEx ELSI study to include evaluations of Tissue Requesters (TRs) and Family Decision Makers (FDMs) of Deceased and At-Risk Children. Collectively, our BPC team is committed to developing an all-encompassing, unparalleled BPC for the dGTEx project to empower the advancement of pediatric research, ELSI challenges, and the development of new clinical approaches to treat pediatric disorders. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,333,206 )
2026	2026	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	5	9/9/2026	NON-COMPETING CONTINUATION	$1,333,206
														Subtotal = $1,333,206

Issue Date FY: 2025 ( Subtotal = $1,357,016 )
2025	2025	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	001	4	9/4/2025	NON-COMPETING CONTINUATION	$1,357,016
2025	2024	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	3	8/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,357,016

Issue Date FY: 2024 ( Subtotal = $2,343,364 )
2024	2024	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	3	8/15/2024	NON-COMPETING CONTINUATION	$2,343,364
														Subtotal = $2,343,364

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	2	3/16/2023	NON-COMPETING CONTINUATION	$0
2023	2022	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	001	2	8/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $3,519,980 )
2022	2022	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	2	8/16/2022	NON-COMPETING CONTINUATION	$3,519,980
														Subtotal = $3,519,980

Issue Date FY: 2021 ( Subtotal = $3,350,000 )
2021	2021	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	001	1	9/14/2021	NEW	$0
2021	2021	NATIONAL DISEASE RESEARCH INTERCHANGE	1601 CHERRY ST STE 1700	PHILADELPHIA	PA	19102	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	1	9/8/2021	NEW	$3,350,000
														Subtotal = $3,350,000

Grand Total All Awards = $11,903,566

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Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project

Award Number: U24HD106537

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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