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Characterizing pediatric genomes through an optimized sequencing approach

Award Number: U24HD090744
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Characterizing pediatric genomes through an optimized sequencing approach - Project Summary/Abstract Expanding our understanding of the genetic contributions and etiologies of congenital disabilities and childhood cancer impacts those affected directly and contributes significantly to related research in adult conditions. This proposal builds on the established HudsonAlpha-St. Jude Genome Sequencing Center (HASJ-GSC) and expands its capabilities to interrogate and integrate data produced by an efficient and experienced genomics resource. The program aims to generate and analyze high-quality sequence and variant data from the most pediatric cancer and congenital disability cohorts possible with available funds over three years. We present here the innovation, capabilities, and experience of the HASJ-GSC to produce data for the Gabriella Miller Kids First Research Program that will be accessible and available to the research community and leveraged to its maximal impact for years to come. We also present a technology expansion and cost reduction plan that increases the number of cases sequenced and analyzed each year. The HASJ-GSC will generate exceptional quality whole-genome sequence and variant data for all samples. The pediatric cancer samples will also be analyzed with RNASeq and whole-exome sequencing. The combined genome, exome, and RNASeq will provide as much resolution as possible toward understanding the genetic and functional genomic changes observed in pediatric cancer. The HASJ-GSC will also support a comprehensive collection of additional methodologies such as long-read DNA and RNA sequencing, functional genomic analyses, and advanced data analysis. These technologies will expand the resolution and types of investigations provided to X01 investigators. The HASJ- GSC will also provide data storage with fast, reliable, and efficient data access, sharing, and reporting for the X01 project researchers. Finally, the HASJ-GSC will support efficient sequence and variant data submission to the Gabriella Miller Kids First Data Resource Center and facilitate submission to the appropriate public databases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $67,663 )
2024	2024	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	001	9	9/6/2024	NON-COMPETING CONTINUATION	$67,663
2024	2023	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	000	8	12/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $67,663

Issue Date FY: 2023 ( Subtotal = $1 )
2023	2023	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	008	8	8/31/2023	NON-COMPETING CONTINUATION	$1
2023	2022	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	006	7	2/6/2023	COMPETING CONTINUATION	$0
2023	2022	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	000	7	11/2/2022	COMPETING CONTINUATION	$0
2023	2022	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	005	7	12/29/2022	COMPETING CONTINUATION	$14,735,063
2023	2022	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	007	7	4/6/2023	COMPETING CONTINUATION	$0
2023	2021	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	004	6	12/29/2022	SUPPLEMENT FOR EXPANSION	-$1,000,000
2023	2021	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	003	6	12/29/2022	NON-COMPETING CONTINUATION	-$6,883,364
2023	2020	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	5	12/29/2022	NON-COMPETING CONTINUATION	-$773,541
2023	2020	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	002	5	12/29/2022	SUPPLEMENT FOR EXPANSION	-$6,078,158
														Subtotal = $1

Issue Date FY: 2022 ( Subtotal = $3,342,308 )
2022	2022	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Trans-NIH Research Support	001	7	9/20/2022	COMPETING CONTINUATION	$3,384,086
2022	2017	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	2	9/8/2022	SUPPLEMENT FOR EXPANSION	-$41,778
														Subtotal = $3,342,308

Issue Date FY: 2021 ( Subtotal = $7,883,364 )
2021	2021	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	004	6	9/15/2021	SUPPLEMENT FOR EXPANSION	$1,000,000
2021	2021	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	003	6	9/7/2021	NON-COMPETING CONTINUATION	$6,883,364
2021	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	002	5	9/4/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	5	2/8/2021	NON-COMPETING CONTINUATION	$0
2021	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	5	10/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,883,364

Issue Date FY: 2020 ( Subtotal = $7,343,500 )
2020	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	006	5	9/9/2020	NON-COMPETING CONTINUATION	$829,064
2020	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	007	5	9/10/2020	SUPPLEMENT FOR EXPANSION	$6,514,436
2020	2019	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	005	4	4/1/2020	COMPETING CONTINUATION	$0
2020	2019	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	004	4	3/23/2020	COMPETING CONTINUATION	$6,336,040
2020	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	003	3	3/23/2020	SUPPLEMENT FOR EXPANSION	-$100,000
2020	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	002	3	3/23/2020	SUPPLEMENT FOR EXPANSION	-$865,000
2020	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	3	3/23/2020	NON-COMPETING CONTINUATION	-$4,898,000
2020	2017	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	2	3/23/2020	SUPPLEMENT FOR EXPANSION	-$473,040
														Subtotal = $7,343,500

Issue Date FY: 2019 ( Subtotal = $5,427,005 )
2019	2019	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	4	9/12/2019	COMPETING CONTINUATION	$5,427,005
2019	2017	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	2	11/5/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $5,427,005

Issue Date FY: 2018 ( Subtotal = $5,863,000 )
2018	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	002	3	9/13/2018	SUPPLEMENT FOR EXPANSION	$100,000
2018	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	3	8/29/2018	NON-COMPETING CONTINUATION	$4,898,000
2018	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	3	9/12/2018	SUPPLEMENT FOR EXPANSION	$865,000
														Subtotal = $5,863,000

Issue Date FY: 2017 ( Subtotal = $7,502,772 )
2017	2017	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	2	7/18/2017	NON-COMPETING CONTINUATION	$4,737,578
2017	2017	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	001	2	9/13/2017	SUPPLEMENT FOR EXPANSION	$2,765,194
														Subtotal = $7,502,772

Issue Date FY: 2016 ( Subtotal = $6,300,000 )
2016	2016	Hudson Alpha Institute of Biotechnology	601 Genome Way	HUNTSVILLE	AL	35806	MADISON	USA	Child Health and Human Development Extramural Research	000	1	9/22/2016	NEW	$6,300,000
														Subtotal = $6,300,000

Grand Total All Awards = $43,729,613

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Characterizing pediatric genomes through an optimized sequencing approach

Award Number: U24HD090744

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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