Friday, August 15, 2025 8/15/2025

Stanford MoTrPAC Site for Genomes, Epigenomes and Transcriptomes

Award Number: U24DK112348
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/13/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

Stanford MoTrPAC Site for Genomes, Epigenomes and Transcriptomes - PROJECT SUMMARY Lack of physical activity is central to numerous health problems. Despite this, we have limited understanding of the molecular components which confer the benefit of physical activity and their diverse impacts across tissues with respect to age, sex, genetics, environment and other objective physiologic, morphometric, and metabolic measures. Identifying these molecular signatures offers new opportunities for treatment and therapeutics. The goal of the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) is to assemble a comprehensive map of the molecular changes that occur in response to physical activity and, when possible, relate these changes to the benefits of physical activity. This map will be greatly facilitated by the application of –omics technologies to identify exercise-responsive genes and to relate their benefits across multiple tissues and contexts. Our Stanford Chemical Analysis Site (CAS) is a core component of the MoTrPAC project. Together with Mount Sinai School of Medicine, we form the Genome, Epigenomics and Transcriptomics (GET) team. At Stanford CAS, we have provided molecular data on 7820 samples as part of both human and rat components of MoTrPAC studies. We have further led the development of key quality control and data analysis pipelines to ensure rigor and reproducibility. Our site has also led key consortium manuscripts and engagement efforts from the animal training study. In the final phase of MoTrPAC, we principally aim to provide a genome for every MoTrPAC participant and a transcriptome for every participant sample and facilitate making this data broadly accessible and useful to the research community. Our site will be responsible for the generation of 15784 transcriptomes using RNA-seq. In addition to this effort, we have proposed to generate chromatin accessibility profiles using ATAC-seq on 1190 muscle and PBMC samples and long read transcriptomes using Iso-Seq on 110 muscle samples. The expected benefits of ATAC-seq and Iso-seq efforts will be to enable (1) mapping regulatory changes using chromatin accessibility data, (2) expand profiling of genetic effects using allele-specific measurements and (3) provide complete isoform data for a reference collection of MoTrPAC samples through exercise intervention. Our site provides critical prior expertise and infrastructure to accomplish these production goals and analyses. We have demonstrated expertise for analysis of collected tissues, compliance with MoTrPAC protocols, collaboration with other Chemical Analysis Sites and all other aspects of the consortium, timely data deposition and support of the Bioinformatics Center and expertise in data sharing, enhancement of rigor and reproducibility in Common Fund projects and leading coordinated publication activities. Our PI team also provides MoTrPAC with important cross-consortia expertise to extend its impacts and ensure timely completion. Overall, we are eager to complete the MoTrPAC program as envisioned, overcome remaining obstacles and rapidly share data, tools and analyses to the larger research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $272,001 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	003	8	7/10/2025	EXTENSION WITH OR WITHOUT FUNDS	$272,001
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	7	4/2/2025	COMPETING CONTINUATION	$308,481
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	7	7/10/2025	COMPETING CONTINUATION	$0
2025	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	6	4/2/2025	NON-COMPETING CONTINUATION	-$308,481
														Subtotal = $272,001

Issue Date FY: 2024 ( Subtotal = $885,999 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	7	8/7/2024	COMPETING CONTINUATION	$885,999
2024	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	6	7/25/2024	NON-COMPETING CONTINUATION	$0
2024	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	6	12/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $885,999

Issue Date FY: 2022 ( Subtotal = $2,736,699 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	6	12/8/2021	NON-COMPETING CONTINUATION	$2,736,699
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	6	8/26/2022	NON-COMPETING CONTINUATION	$0
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	5	8/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,736,699

Issue Date FY: 2021 ( Subtotal = $4,020,046 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	5	7/15/2021	NON-COMPETING CONTINUATION	$0
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	5	12/11/2020	NON-COMPETING CONTINUATION	$4,020,046
2021	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	4	7/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,020,046

Issue Date FY: 2020 ( Subtotal = $4,481,145 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	4	12/24/2019	NON-COMPETING CONTINUATION	$4,481,145
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	4	7/31/2020	NON-COMPETING CONTINUATION	$0
2020	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	3	7/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,481,145

Issue Date FY: 2019 ( Subtotal = $2,529,956 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	002	3	8/12/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	3	12/19/2018	NON-COMPETING CONTINUATION	$2,529,956
2019	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	001	2	8/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,529,956

Issue Date FY: 2018 ( Subtotal = $1,734,178 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	2	3/5/2018	NON-COMPETING CONTINUATION	$1,734,178
														Subtotal = $1,734,178

Issue Date FY: 2017 ( Subtotal = $241,432 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	9/19/2017	SUPPLEMENT FOR EXPANSION	$157,976
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Trans-NIH Research Support	000	1	12/12/2016	NEW	$83,456
														Subtotal = $241,432

Grand Total All Awards = $16,901,456

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Stanford MoTrPAC Site for Genomes, Epigenomes and Transcriptomes

Award Number: U24DK112348

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/13/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer