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Michigan MoTrPAC Chemical Analysis Site (MiCAS)

Award Number: U24DK112342
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/08/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Michigan MoTrPAC Chemical Analysis Site (MiCAS) - The University of Michigan’s Molecular Transducers of Physical Activity (MoTrPAC) Chemical Analysis Site (MiCAS) has been providing large-scale, high-quality untargeted metabolomics analysis in collaboration with the MoTrPAC consortium. In this renewal, MiCAS will continue to provide metabolomics analysis by reversed- phase chromatography with ionization in both the positive and negative mode and by ion-pairing chromatography in the negative mode. In addition, MiCAS will perform steroid analysis for baseline samples for each enrollee. These studies will be led by a team of chemists, spectroscopists, computer scientists and statisticians in the Michigan Metabolomics Core which is part of the University of Michigan’s Biomedical Research Core Facilities. During the preclinical phase and the initial human phase, MiCAS investigators carried out analysis of thousands of sample derived from animals and people recruited by the MoTrPAC Clinical Centers. In the final phase of the study, MiCAS will continue to provide analysis of blood, skeletal muscle and adipose tissue on the ‘PostCOVID’ sample collection expected to be 1980 subjects enrolled in four related clinical studies are ongoing. The largest is assessing sedentary adults randomly assigned to one of three groups: Endurance Exercise (EE; N=840), Resistance Exercise (RE; N=840), or a control group with no exercise (N=300). The participants in the intervention groups are scheduled to undergo a single acute testing bout of either EE or RE at the beginning and end of the study of a 12-week training period which is accompanied timed collection of blood, skeletal muscle, and adipose tissue. Control group participants undergo similar biospecimen collections before and after 12 weeks of usual activity. Additionally, molecular changes in response to acute exercise are being assessed in 300 highly active (HA) adults, with N=150 participating in EE and N=150 in RE. These individuals receive a single testing bout of either EE or RE, depending on their usual training modality. Finally, in a pediatric study, both highly active (HA; N=50) and low active (LA; N=270) children and adolescents will be analyzed in a cross-sectional study. A randomized 12-week EE training study is being conducted with LA children and adolescents with N=120 participants randomized to an EE group and N=50 in a control group. Adults and children will be sampled according to the approved MoTrPAC Tissue Analysis Plan. MiCAS investigators will continue to develop new approaches to analyze metabolomics data, including a novel approach to name the thousands of unknown molecular features found in untargeted metabolomics which may serve as molecular transducers. MiCAS personnel also lead and participate in all activities of the MoTrPAC consortium, including serving on committees, participating in consortium meetings, and participating in data analysis, integration of data across ‘omics types, writing and editing manuscripts arising from the consortium’s activities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	001	7	4/2/2025	COMPETING CONTINUATION	$236,474
2025	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	6	4/2/2025	NON-COMPETING CONTINUATION	-$236,474
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $955,199 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	002	7	8/7/2024	COMPETING CONTINUATION	$955,199
2024	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	001	6	7/30/2024	NON-COMPETING CONTINUATION	$0
2024	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	6	11/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $955,199

Issue Date FY: 2022 ( Subtotal = $1,547,687 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	002	6	9/15/2022	NON-COMPETING CONTINUATION	$0
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	6	12/9/2021	NON-COMPETING CONTINUATION	$1,547,687
2022	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	001	5	9/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,547,687

Issue Date FY: 2021 ( Subtotal = $1,772,233 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	5	12/17/2020	NON-COMPETING CONTINUATION	$1,772,233
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	002	5	6/8/2021	NON-COMPETING CONTINUATION	$0
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	001	4	6/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,772,233

Issue Date FY: 2020 ( Subtotal = $1,901,317 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	001	4	1/17/2020	NON-COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	003	4	7/24/2020	NON-COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	4	1/3/2020	NON-COMPETING CONTINUATION	$1,901,317
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	002	3	7/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,901,317

Issue Date FY: 2019 ( Subtotal = $2,883,959 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	003	3	7/29/2019	NON-COMPETING CONTINUATION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	6/17/2019	SUPPLEMENT FOR EXPANSION	$1,013,183
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	3	12/19/2018	NON-COMPETING CONTINUATION	$1,870,776
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	002	2	7/29/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,883,959

Issue Date FY: 2018 ( Subtotal = $908,991 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	2	3/8/2018	NON-COMPETING CONTINUATION	$908,991
														Subtotal = $908,991

Issue Date FY: 2017 ( Subtotal = $242,069 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$77,500
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	9/19/2017	SUPPLEMENT FOR EXPANSION	$164,569
														Subtotal = $242,069

Grand Total All Awards = $10,211,455

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Michigan MoTrPAC Chemical Analysis Site (MiCAS)

Award Number: U24DK112342

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/08/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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