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Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD

Award Number: U24DK062429
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2002
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD - NOTE: You must submit in Word format, not PDF, for eRA to update all the systems. The NIDDK IBD Genetics Consortium’s (IBDGC) mission is to characterize the genetic architecture of IBD phenotypes, and to elucidate the biological mechanisms by which genetic variants influence IBD pathophysiology, phenotypes and clinical course. This proposal is to serve as the data coordinating center (DCC) for the IBDGC in a cooperative agreement with genetics research centers (GRCs) to benefit the field broadly. The DCC has played an essential role in the International IBD Genetics Consortium (IIBDGC), resulting in very large, well-powered cohorts that can statistically refine association signals. In Aim 1, the DCC will optimize power and enhance pathophysiologic insight in clinical areas of unmet need in IBD by coordinating, standardizing and tracking increased recruitment across the GRCs. By so doing, substantially increased power to refine allelic effects may be achieved. Integration with multi-omic ATAC + transcriptome single cell data may provide further refinement of association signals between Crohn’s disease and ulcerative colitis and across populations. Complete mapping of sequence data for the NIDDK IBDGC lymphoblastoid lymphocyte repository from over 9000 patients will enable for broad use and dissemination and assist Ancillary studies. In Aim 2, the DCC will provide high-quality operational services optimized to the scientific objectives of the Consortium, including data collection, management and distribution; guidance in study design and data analysis; researching and facilitating use of new platforms and technologies; and supporting Consortium governance, communication and administration. We shall also substantially enhance our data sharing mechanisms and website to promote and facilitate discovery and usage by the IBD community at large. In Aim 3, in selected clinical scenarios of unmet medical needs, the DCC will enable longitudinal analyses prioritized by the NIDDK IBDGC Steering Committee, and to scale and standardize multi- omic cellular data. The NIDDK IBDGC has made investments in serial biosampling in ileal resection Crohn’s disease cohorts, which powerfully tracks the earliest steps in disease recurrence. Mechanistic insight may well be accrued via serial sampling (systemic and tissue-based) in other key scenarios, such as perianal fistulae in Crohn’s disease. The power of GWAS locus identification lies in the definitive mapping from trait to outcome (disease development). Given the complex genetic architecture of IBD, comprehensive explication of multi-omics across the entire IBD patient population will provide a key means of defining cellular and therapeutic mechanisms, enabling Precision Medicine for IBD broadly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,600,000 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	26	9/11/2025	NON-COMPETING CONTINUATION	$1,600,000
2025	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	11/4/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,600,000

Issue Date FY: 2024 ( Subtotal = $2,027,502 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	7/26/2024	NON-COMPETING CONTINUATION	$1,536,002
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	8/27/2024	SUPPLEMENT FOR EXPANSION	$491,500
														Subtotal = $2,027,502

Issue Date FY: 2023 ( Subtotal = $1,600,000 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	24	7/28/2023	NON-COMPETING CONTINUATION	$1,600,000
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	3/10/2023	COMPETING CONTINUATION	$0
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	1/11/2023	COMPETING CONTINUATION	$895,750
2023	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	1/11/2023	NON-COMPETING CONTINUATION	-$895,750
														Subtotal = $1,600,000

Issue Date FY: 2022 ( Subtotal = $1,210,619 )
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	9/14/2022	COMPETING CONTINUATION	$1,210,619
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	10/14/2021	NON-COMPETING CONTINUATION	$0
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	5/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,210,619

Issue Date FY: 2021 ( Subtotal = $1,452,414 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	9/3/2021	NON-COMPETING CONTINUATION	$1,452,414
2021	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	3/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,452,414

Issue Date FY: 2020 ( Subtotal = $1 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	8/17/2020	NON-COMPETING CONTINUATION	$1
2020	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	11/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2019 ( Subtotal = $448,779 )
2019	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	9/2/2019	NON-COMPETING CONTINUATION	$1,453,509
2019	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	1/28/2019	COMPETING CONTINUATION	-$1,004,730
														Subtotal = $448,779

Issue Date FY: 2018 ( Subtotal = $4,246,160 )
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	9/11/2018	NON-COMPETING CONTINUATION	$1,472,877
2018	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	1/16/2018	COMPETING CONTINUATION	$1,768,553
2018	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	1/16/2018	COMPETING CONTINUATION	$1,004,730
														Subtotal = $4,246,160

Issue Date FY: 2017 ( Subtotal = $1,455,334 )
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	9/19/2017	COMPETING CONTINUATION	$1,455,334
														Subtotal = $1,455,334

Grand Total All Awards = $14,040,809

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Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD

Award Number: U24DK062429

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2002

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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