Thursday, November 21, 2024 11/21/2024

Developing and applying common data elements to enhance clinical and translational research, healthcare access and outcomes in inflammatory bowel disease

Award Number: U24DK062429
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

ABSTRACT The inflammatory bowel diseases (IBD) are comprised equally of two major subtypes, Crohn's disease and ulcerative colitis, with a peak age of onset between 15-30 years of age. As for many immune-mediated inflammatory diseases (IMID), IBD incidence is rising world-wide, especially among diverse populations. Although IBD prevalence in LatinX and Black populations in North America is lower, compared to European ancestry populations, outcomes are often worse, for myriad reasons, including diagnostic delays and reduced access to care and disease-modifying treatments. The NIDDK IBD Genetics Consortium (IBDGC) was established in 2002, with the major goal of developing a thorough understanding of the genetic structure of IBD to elucidate the pathophysiology of IBD for improved patient outcomes. The NIDDK IBDGC is comprised of 7 Genetics Research Centers (GRCs) sited at major IBD centers in the United States and Canada, and a Data Coordinating Center (DCC). Biospecimens, immortalized cell lines and phenotypic and genomic datasets from the IBDGC are available via the NIDDK Central Repository and dbGaP. The IBDGC also acts as a coordinating center for the International IBD Genetics Consortium. The major priority of the IBDGC during the current funding period (2022-2027) is to enhance recruitment of LatinX and Black IBD cohorts, for both social justice and scientific reasons. The NIDDK IBDGC has developed protocols and workflows to enhance diverse patient recruitment throughout North America (including direct to patient), reaching beyond highly resourced IBD-specialized centers. Common data elements (CDEs) for IBD do not currently exist. Therefore, in this supplement request, the IBDGC DCC, in collaboration with the University of Miami GRC and with other IBDGC investigators, is proposing development of IBD-related CDEs for submission to the NIH CDE Repository, NIH endorsement and dissemination. CDE development will leverage extant forms developed by the NIDDK IBDGC. Form-based, research-focused CDEs will be integrated with major model-based research and clinical care, such as HL7/FHIR, PheCodes, LOINC and OMOP structures, with harmonization and validation between two major health systems, the University of Miami and the Icahn School of Medicine at Mount Sinai, New York. CDEs and form-based models directed toward patient - primary care provider - general gastroenterologist - IBD specialist referral efficiencies will be developed. CDEs will provide the building blocks by which AI-assisted forms and models can be developed for patients, primary care providers, general gastroenterologists and IBD subspecialty centers. Development of CDEs for IBD will enhance clinical and translational research in IBD, facilitate recruitment among diverse populations, enhance opportunities for collaboration and allow extant IBD resources to be more fully leveraged, such as the lymphoblastoid cell lines, other biospecimens and matched genetic and phenotypic data deposited by the IBDGC at the NIDDK Central Repository, providing broad community value.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	11/4/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,027,502 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	8/27/2024	SUPPLEMENT FOR EXPANSION	$491,500
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	7/26/2024	NON-COMPETING CONTINUATION	$1,536,002
														Subtotal = $2,027,502

Issue Date FY: 2023 ( Subtotal = $1,600,000 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	24	7/28/2023	NON-COMPETING CONTINUATION	$1,600,000
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	1/11/2023	COMPETING CONTINUATION	$895,750
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	3/10/2023	COMPETING CONTINUATION	$0
2023	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	1/11/2023	NON-COMPETING CONTINUATION	-$895,750
														Subtotal = $1,600,000

Issue Date FY: 2022 ( Subtotal = $1,210,619 )
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	9/14/2022	COMPETING CONTINUATION	$1,210,619
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	5/9/2022	NON-COMPETING CONTINUATION	$0
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	10/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,210,619

Issue Date FY: 2021 ( Subtotal = $1,452,414 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	9/3/2021	NON-COMPETING CONTINUATION	$1,452,414
2021	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	3/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,452,414

Issue Date FY: 2020 ( Subtotal = $1 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	8/17/2020	NON-COMPETING CONTINUATION	$1
2020	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	11/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2019 ( Subtotal = $448,779 )
2019	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	9/2/2019	NON-COMPETING CONTINUATION	$1,453,509
2019	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	1/28/2019	COMPETING CONTINUATION	-$1,004,730
														Subtotal = $448,779

Issue Date FY: 2018 ( Subtotal = $4,246,160 )
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	9/11/2018	NON-COMPETING CONTINUATION	$1,472,877
2018	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	1/16/2018	COMPETING CONTINUATION	$1,004,730
2018	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	1/16/2018	COMPETING CONTINUATION	$1,768,553
														Subtotal = $4,246,160

Issue Date FY: 2017 ( Subtotal = $1,455,334 )
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	9/19/2017	COMPETING CONTINUATION	$1,455,334
														Subtotal = $1,455,334

Grand Total All Awards = $12,440,809

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Developing and applying common data elements to enhance clinical and translational research, healthcare access and outcomes in inflammatory bowel disease

Award Number: U24DK062429

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer