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Michigan-Pittsburgh-Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies

Award Number: U24DE026915
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Michigan-Pittsburgh-Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies - Abstract The translation of innovative tissue engineering/regenerative medicine (TE/RM) technologies requires a new approach to bring TE/RM in dental, oral and craniofacial (DOC) technologies to clinical practice. To meet this need, an integrated, multidisciplinary Resource Center (RC) has been established as a partnership between University of Michigan, the University of Pittsburgh/McGowan Institute, Harvard University/Wyss Institute for Biologically Inspired Engineering, and clinical and industrial experts. This RC, named the Michigan-Pittsburgh- Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies (MPWRM TechDOC), consists of leaders with clinical, basic science, engineering and business expertise, and an infrastructure to support navigation through the regulatory process and clinical trials. The goal of this RC is to translate TE/RM innovations that address the ongoing clinical need to restore or create healthy, functional DOC tissues. Central to our proposal is the use of a unique academic-industry assessment model, assembly of an outstanding team of experts, and a menu of innovative DOC technologies that are heavily focused on craniomaxillofacial and dental therapies. The vision of this RC is that the most promising technologies in TE/RM will be catalyzed, nurtured and expedited through a novel academic partnership to safely and effectively regenerate, reconstruct and restore functional DOC tissues. To achieve this vision, we will: 1) Implement the organizational structure of the consortium to prioritize and de-risk TE/RM technologies for translation to clinical practice. Support teams, subject matter experts (SMEs), and partnerships coordinated during our Planning Grants will be empowered to provide integrated assessment and translational pathways. 2) Implement processes to select regenerative technologies to translate to clinical practice, by utilizing a unique academic-industry assessment approach that emulates the industry proven Stage-Gate© model; execute technology validation, and implement plans to facilitate cGLP/cGMP activities for FDA submissions. Upon completion of the Stage II grant, we will have implemented the RC structure and operations, and provided training and education for our stakeholders to translate DOC technologies utilizing sound scientific and engineering, business, regulatory, and manufacturing principles. In doing so, the MPWRM TechDOC will be poised to advance TE/RM technologies through the translational pipeline in Phase III, leading to a transformation of patient care in dental, oral and craniofacial medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$20,181 )
2023	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	4/25/2023	NON-COMPETING CONTINUATION	-$20,181
														Subtotal = -$20,181

Issue Date FY: 2022 ( Subtotal = -$574,475 )
2022	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	9/27/2022	NON-COMPETING CONTINUATION	-$574,475
														Subtotal = -$574,475

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	2/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	1/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $3,893,066 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	3	3/4/2019	NON-COMPETING CONTINUATION	$3,893,066
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	2	11/6/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,893,066

Issue Date FY: 2018 ( Subtotal = $3,894,093 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	2	2/22/2018	NON-COMPETING CONTINUATION	$3,894,093
														Subtotal = $3,894,093

Issue Date FY: 2017 ( Subtotal = $3,911,029 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	1	2/27/2017	NEW	$0
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	1	2/21/2017	NEW	$3,911,029
														Subtotal = $3,911,029

Grand Total All Awards = $11,103,531

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Michigan-Pittsburgh-Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies

Award Number: U24DE026915

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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