Wednesday, July 23, 2025 7/23/2025

CASCADE Coordinating Center

Award Number: U24CA275417
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/07/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

CASCADE Coordinating Center - Project Summary/Abstract Women living with HIV (WLWH) have a higher risk for acquisition, persistence, and progression of cervical human papillomavirus (HPV) to precancerous lesions, which, in the absence of effective screening and treatment services, can progress to invasive cancer at five-to-six times higher rates than in women without HIV. The massive global mobilization of humanitarian resources spanning over the past couple of decades, through initiatives such as the US President's Emergency Plan for AIDS Relief (PEPFAR), has resulted in millions of WLWH in low- and middle-income countries (LMICs) now accessing affordable antiretroviral therapy and consequently living longer lives. Yet, their risk for cervical cancer continues unabated since effective screening and pre-cancer treatment services remain unavailable in most LMICs. The HIV/Cervical Cancer Prevention “CASCADE” Clinical Trials Network plans to conduct pragmatic clinical trials evaluating the effectiveness of clinically proven interventions to optimize the cervical cancer screening, management, and pre-cancer treatment cascade for WLWH. These clinical trials will be conducted in intended- use environments in resource-constrained settings in LMICs and in regions with health disparities in the United States. The CASCADE Network will have four major scientific focus areas: increasing screening uptake, improving management of screen positives, facilitating pre-cancer treatment access, and optimizing pre-cancer treatment for cervical cancer prevention in WLWH. The CASCADE Network clinical trials will focus on the measurement of the clinical effectiveness of interventions in intended use settings while gathering crucial information informing the implementation and scale-up of such interventions across the cascade of screening and pre-cancer treatment for WLWH. Such hybrid effectiveness-implementation designs will primarily focus on clinical effectiveness endpoints such as HPV positivity rates and/or pre-cancer detection/incidence/recurrence rates and will secondarily gather data on implementation-informing aspects such as costs, acceptability, and intervention fidelity while studying implementation strategy. To support the CASCADE Clinical Trials Network in partnership with the NCI's Division of Cancer Prevention, CASCADE Research Bases and CASCADE Clinical Sites, the CASCADE Network Coordinating Center will (i) provide overall network coordination and facilitate scientific review of network clinical trial concepts and protocols, (ii) provide centralized support for data management for network clinical trials, and (iii) conduct independent risk-appropriate auditing of network clinical trials. The CASCADE Network Coordinating Center will serve as the organizational and coordination hub for the CASCADE Network and provide multi-disciplinary expertise in program and operations management, clinical research informatics/information technology, and clinical trials auditing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON ST STE 203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	000	3	1/13/2025	NON-COMPETING CONTINUATION	$0
2025	2024	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON ST STE 203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	001	3	3/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $990,038 )
2024	2024	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON ST STE 203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	000	3	7/1/2024	NON-COMPETING CONTINUATION	$990,038
														Subtotal = $990,038

Issue Date FY: 2023 ( Subtotal = $1,416,880 )
2023	2023	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	003	2	8/25/2023	NON-COMPETING CONTINUATION	$0
2023	2023	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	001	2	5/25/2023	NON-COMPETING CONTINUATION	$1,416,880
2023	2022	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	002	1	8/24/2023	NEW	$0
2023	2022	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	000	1	10/19/2022	NEW	$0
														Subtotal = $1,416,880

Issue Date FY: 2022 ( Subtotal = $1,447,101 )
2022	2022	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	001	1	9/20/2022	NEW	$450,000
2022	2022	FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC.	1371 BEACON STREET, SUITE #203	BROOKLINE	MA	02446	NORFOLK	USA	Cancer Cause and Prevention Research	000	1	9/7/2022	NEW	$997,101
														Subtotal = $1,447,101

Grand Total All Awards = $3,854,019

Top

All Categories

About

Search

Reports

Data Submission

Award Information

CASCADE Coordinating Center

Award Number: U24CA275417

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/07/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer