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Pathway, Network and Spatiotemporal Integration of Cancer Genomics Data

Award Number: U24CA264027
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Pathway, Network and Spatiotemporal Integration of Cancer Genomics Data - PROJECT SUMMARY Cancer sequencing projects have demonstrated that tumors are tremendously heterogeneous, reflecting the large diversity of perturbations in the cellular machinery that promote tumor growth and metastasis. Tumors from different patients with the same type of cancer have a diverse collection of genomic, epigenomic, and transcriptomic aberrations. Moreover, a tumor from a single patient is a mixture of cell types including normal cells, stroma, and multiple subpopulations of cancerous cells. We propose a Genome Data Analysis Center (GDAC) that will develop and apply novel computational approaches to address the challenges of inter-tumor and intra-tumor heterogeneity. This GDAC will integrate data from multiple genome characterization platforms, multiple sequencing technologies -- including bulk, single-cell, and spatial sequencing technologies – and leverage prior knowledge of pathways and interaction networks to explain clinical phenotypes and inform treatment strategies. The GDAC will perform pathway and network integration of genome characterization data, spatial analysis of tumor microenvironment, and temporal analysis of intra-tumor heterogeneity, tumor evolution, and network rewiring. These analyses will enable more precise translation of cancer genome characterization efforts into clinical utility for a larger fraction of cancer patients. The GDAC will continue the ongoing contributions of the PIs to the current Genome Data Analysis Network (GDAN) and previous efforts in The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) projects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $291,430 )
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	002	4	8/21/2024	NON-COMPETING CONTINUATION	$291,430
2024	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	001	3	7/1/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	000	3	11/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $291,430

Issue Date FY: 2023 ( Subtotal = $301,101 )
2023	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	000	3	9/8/2023	NON-COMPETING CONTINUATION	$301,101
														Subtotal = $301,101

Issue Date FY: 2022 ( Subtotal = $307,697 )
2022	2022	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	000	2	9/12/2022	NON-COMPETING CONTINUATION	$307,697
														Subtotal = $307,697

Issue Date FY: 2021 ( Subtotal = $338,099 )
2021	2021	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Cancer Detection and Diagnosis Research	000	1	9/22/2021	NEW	$338,099
														Subtotal = $338,099

Grand Total All Awards = $1,238,327

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Pathway, Network and Spatiotemporal Integration of Cancer Genomics Data

Award Number: U24CA264027

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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