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UCSC-Buck Genome Data Analysis Center for the Genomic Data Analysis Network v2.0

Award Number: U24CA264009
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/07/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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UCSC-Buck Genome Data Analysis Center for the Genomic Data Analysis Network v2.0 - ABSTRACT Tumor heterogeneity -- the complex mix of tumor subclones, the cell-of-origin that first became transformed, the evolution of tumor subclones under selective pressures of the body and due to treatment, and the interplay of these cells with the tumor microenvironment (TME) -- contributes to the character, behavior, and mystery of tumors and is a key determinant of cancer progression and a patient’s response to therapy. Large-scale genomics projects like the Cancer Genome Atlas (TCGA) and the Genome Data Analysis Network (GDAN) have revealed important characteristics and patterns from a multi-omics overview of various tumor types. However, it remains a mystery on how to maximize the use of these data to choose the best course of treatment for an individual patient. The proposed GDAN will close this gap in knowledge by collecting clinical information and outcomes endpoints alongside the multiple omics platforms that will provide key linkages upon which to train supervised computational approaches. We propose to contribute our key competencies of pathway analysis, integrative machine-learning, mRNA-seq analysis, assessment of driving somatic mutations, and visualization of high-throughput datasets to serve the future GDAN analysis working groups (AWGs) to achieve these goals. We will collect and share widely a database of gene expression signatures that capture cell state information gleaned from the large collection of single-cell mRNA sequencing data such as from the Human Cell Atlas (Aim 1). In addition, we will contribute our existing, and novel extensions to, machine-learning approaches like AKIMATE to maximally use these signatures and others in combination with AWG-approved omics datasets as features to train accurate predictors of response for the GDAN’s studies like ALCHEMIST (Aim 2). Our proposal will adapt the TumorMap to benefit weekly analysis and bolster the exploration and publication of results. Specifically, we will work with the group to create new maps that show the TME and TIC comparisons of the patient samples separately to help elucidate new important subtypes implied by the collected data (Aim 3). As we have done for the past twelve years for TCGA and the GDAN, we propose to continue working closely with the consortium in these endeavors to significantly enrich our understanding of the molecular and cellular basis of tumor heterogeneity and its influence on cancer progression and treatment response.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $385,872 )
2025	2025	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	000	5	8/29/2025	NON-COMPETING CONTINUATION	$385,872
														Subtotal = $385,872

Issue Date FY: 2024 ( Subtotal = $426,189 )
2024	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	002	4	8/6/2024	NON-COMPETING CONTINUATION	$366,578
2024	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	000	3	6/26/2024	NON-COMPETING CONTINUATION	$59,611
2024	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	001	3	7/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $426,189

Issue Date FY: 2023 ( Subtotal = $306,614 )
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	000	3	8/22/2023	NON-COMPETING CONTINUATION	$306,614
														Subtotal = $306,614

Issue Date FY: 2022 ( Subtotal = $378,154 )
2022	2022	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	000	2	7/25/2022	NON-COMPETING CONTINUATION	$378,154
														Subtotal = $378,154

Issue Date FY: 2021 ( Subtotal = $412,872 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Cancer Detection and Diagnosis Research	000	1	9/7/2021	NEW	$412,872
														Subtotal = $412,872

Grand Total All Awards = $1,909,701

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UCSC-Buck Genome Data Analysis Center for the Genomic Data Analysis Network v2.0

Award Number: U24CA264009

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/07/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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