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Patient Derived Cancer Model (PDCM) Finder

Award Number: U24CA253539
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Patient Derived Cancer Model (PDCM) Finder - Project Summary - Patient Derived Cancer Model (PDCM) Finder An area of significant growth in cancer research is the diversity and volume of low passage human cancer cell lines, three-dimensional organoid cultures and patient-derived tumor xenografts (PDX) known as Patient Derived Cancer Models (PDCM). This project will therefore aggregate, harmonize and integrate diverse PDCM data, extending our previous resource PDX Finder by inclusion of novel models, making these FAIR (Findable, Accessible, Interoperable, Reusable) compliant and cloud accessible, for example in the NCI Research Commons. PCDM Finder will address challenges with searching over many repositories for models, incompatible standards that make analysis and reuse of models difficult, molecular datasets annotated with insufficient information that prevent cloud-based analyses and the need for more community awareness in providing FAIR- compliant data to maximize the impact of their work. To address these challenges, PDCM Finder has 3 tasks: 1) Enable cancer researchers to Find and Access models by enhancing our current resource to deliver the PDCM Finder, 2) Aggregate and Integrate PDCM datasets to ensure Interoperability and Reusability for the NCI Cancer Research Commons, and 3) Perform targeted community outreach during all stages of the project to determine and prioritize requirements, guide development and promote the PDCM Finder resource. The expected outcomes are users will be able to find, group and locate PDCM models of all types based on community defined attributes (e.g. diagnosis, oncogenic mutation); explore and download molecular data summaries and drug response data from the PDCM portal; aggregate and analyze harmonized PDCM molecular datasets on cloud based analysis platforms. This will accelerate cancer research by allowing doctors and researchers to find PDCM data that best matches their patients and/or research questions and explore new therapeutic avenues for patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	000	5	4/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $444,149 )
2024	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	001	5	9/6/2024	NON-COMPETING CONTINUATION	$444,149
2024	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	000	4	5/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $444,149

Issue Date FY: 2023 ( Subtotal = $459,648 )
2023	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	002	4	8/9/2023	NON-COMPETING CONTINUATION	$459,648
2023	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	001	3	5/22/2023	NON-COMPETING CONTINUATION	$0
2023	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Cancer Biology Research	000	3	5/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $459,648

Issue Date FY: 2022 ( Subtotal = $468,815 )
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Cancer Biology Research	002	3	7/27/2022	NON-COMPETING CONTINUATION	$468,815
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Cancer Biology Research	000	2	4/6/2022	NON-COMPETING CONTINUATION	$0
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Cancer Biology Research	001	2	6/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $468,815

Issue Date FY: 2021 ( Subtotal = $532,409 )
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Cancer Biology Research	001	2	7/26/2021	NON-COMPETING CONTINUATION	$532,409
2021	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Cancer Biology Research	000	1	6/24/2021	NEW	$0
														Subtotal = $532,409

Issue Date FY: 2020 ( Subtotal = $535,159 )
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Cancer Biology Research	000	1	9/10/2020	NEW	$535,159
														Subtotal = $535,159

Grand Total All Awards = $2,440,180

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Patient Derived Cancer Model (PDCM) Finder

Award Number: U24CA253539

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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