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Overture: A Multi-Scale Data Platform for Cancer Genomics Research

Award Number: U24CA253529
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Overture: A Multi-Scale Data Platform for Cancer Genomics Research - Project Summary/Abstract Overture is a collection of modular, open-source software components designed to make the management of big-data genomic projects both easy and more cost effective. The Overture system promotes FAIR data sharing of cancer genomic datasets by overcoming the major obstacles in storing, managing, exploring, and distributing massive genome-scale datasets. In this proposed project, we will implement a turnkey Overture Data Management System (DMS) to provide a complete solution to manage cancer genomic data throughout the data life cycle, and to continue lowering the technical barriers faced by researchers in the cancer informatics community. To extend the capabilities and potential of the Overture DMS, we will establish a new software framework for integration with third-party visualization applications, and for data exchange with analysis platforms. This framework will empower the community to continue developing extremely valuable visualization applications for specific research interests and datatypes, and to contribute them as “apps” to be integrated with the Overture DMS. Over the next five years, we will: (1) combine the core set of Overture components into a scalable DMS installation bundle to promote both local and cloud deployment for a range of small to consortia-scale datasets; (2) extend the DMS with third-party visualization and analysis tools through a novel software data integration framework; (3) enhance data access controls by implementing Global Alliance for Genomics and Health (GA4GH) Passport and Data Use Ontology standards; (3) enable federated searching within cancer datasets across different Overture platforms; and (4) improve outreach and community resources to meet the needs of bioinformaticians, data producers and managers, data scientists, and clinical researchers. The Overture DMS will be a valuable resource for removing complications of large-scale data management from researchers, allowing the advancement of scientific research by increasing data sharing and discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $510,481 )
2024	2024	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Cancer Biology Research	003	4	8/7/2024	NON-COMPETING CONTINUATION	$510,481
2024	2023	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Cancer Biology Research	002	3	6/7/2024	NON-COMPETING CONTINUATION	$0
2024	2023	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Cancer Biology Research	000	3	1/8/2024	NON-COMPETING CONTINUATION	$0
2024	2023	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Cancer Biology Research	001	3	2/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $510,481

Issue Date FY: 2023 ( Subtotal = $526,064 )
2023	2023	ONTARIO INSTITUTE FOR CANCER RESEARCH INSTITUT ONTARIEN DE RECHERCHE SUR LE CANCER	661 UNIVERSITY AVE	TORONTO	ON			CAN	Cancer Biology Research	002	3	8/16/2023	NON-COMPETING CONTINUATION	$526,064
2023	2022	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Cancer Biology Research	001	2	2/22/2023	NON-COMPETING CONTINUATION	$0
2023	2022	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Cancer Biology Research	000	2	11/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $526,064

Issue Date FY: 2022 ( Subtotal = $526,601 )
2022	2022	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Cancer Biology Research	000	2	7/20/2022	NON-COMPETING CONTINUATION	$526,601
														Subtotal = $526,601

Issue Date FY: 2021 ( Subtotal = $534,624 )
2021	2021	ONTARIO INSTITUTE FOR CANCER RESEARCH	661 UNIVERSITY AVE SUITE 510	TORONTO	ON			CAN	Cancer Biology Research	000	1	9/9/2021	NEW	$534,624
														Subtotal = $534,624

Grand Total All Awards = $2,097,770

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Overture: A Multi-Scale Data Platform for Cancer Genomics Research

Award Number: U24CA253529

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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