Friday, June 20, 2025 6/20/2025

Integrative miRNA data analysis for clinical cancer genomics

Award Number: U24CA210952
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2022

Group Awards By:

View Award Description

Integrative miRNA data analysis for clinical cancer genomics - PROJECT SUMMARY The proposed research has two broad, long-term objectives. First, it seeks to shift medical practice toward more personalized treatments, by applying innovative methods to analyze and integrate DNA, RNA and protein data generated by a large network of GDAN researchers in a miRNA-centric framework. Analyses will identify cancer subtypes, and individual patients within a subtype, in which alterations in the expression of certain miRNAs influence cancer pathogenesis and drug response. Second, the proposed research seeks to shift cancer genomics research by allowing a diverse group of cancer researchers to flexibly access and use the project’s cancer genomics data, and microRNA-centric results and methods, through a cloud computing framework. The proposed research has three specific aims: 1) Build a computational pipeline for processing and analysis of miRNA data, 2) Elucidate the regulation of and by miRNAs through integrative analysis, and 3) Delineate the role of miRNAs in cancer progression and treatment using predictive modeling. Research design and methods: 1) Processing and analysis of miRNA data. We will process total RNA sequence data to identify expressed miRNAs, and extend the current processing pipeline to identify potentially functional miRNA sequence variants. We will apply our miRNA-centric analyses developed for The Cancer Genome Atlas project to identify: subtypes within a cancer, miRNAs that are associated with survival, miRNA targeting effects on gene and protein expression, and cis-effects of copy number and DNA methylation on miRNA abundances. 2) Regulation of and by miRNAs. Collaborating within the research network, we will extend our analysis methods to take into account additional datatypes and functional contexts that influence how miRNAs are regulated, and how they regulate genes and their products. 3) Predictive modeling. As the research network will have detailed clinical data and multiplatform genomic data, we will apply machine learning algorithms in a novel context to key sets of genes, proteins and miRNAs that predict clinical outcomes like survival and drug response. 4) Cloud computing. We will make our data, analysis methods and results readily available to a broad group of researchers within a cloud computing framework.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$244,422 )
2025	2020	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Detection and Diagnosis Research	000	6	10/1/2024	NON-COMPETING CONTINUATION	-$244,422
														Subtotal = -$244,422

Issue Date FY: 2023 ( Subtotal = -$96,917 )
2023	2020	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Detection and Diagnosis Research	000	6	8/25/2023	NON-COMPETING CONTINUATION	-$96,917
														Subtotal = -$96,917

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Detection and Diagnosis Research	000	6	2/4/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $398,334 )
2020	2020	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	002	6	8/5/2020	NON-COMPETING CONTINUATION	$398,334
2020	2019	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	001	5	1/24/2020	NON-COMPETING CONTINUATION	$0
2020	2019	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	000	5	1/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $398,334

Issue Date FY: 2019 ( Subtotal = $386,440 )
2019	2019	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	006	5	9/6/2019	NON-COMPETING CONTINUATION	$386,440
2019	2018	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	002	4	5/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2019	2018	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	000	3	12/19/2018	NON-COMPETING CONTINUATION	-$397,386
2019	2018	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	001	4	12/19/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$397,386
2019	2018	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	004	3	9/3/2019	NON-COMPETING CONTINUATION	-$1
2019	2018	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	005	4	9/3/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$235,320
2019	2017	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	003	2	9/3/2019	NON-COMPETING CONTINUATION	-$235,319
														Subtotal = $386,440

Issue Date FY: 2018 ( Subtotal = $397,387 )
2018	2018	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	000	3	9/6/2018	NON-COMPETING CONTINUATION	$397,387
														Subtotal = $397,387

Issue Date FY: 2017 ( Subtotal = $398,402 )
2017	2017	BRITISH COLUMBIA CANCER AGENCY BRANCH	600 10TH AVE W	VANCOUVER	BC	V5Z 4E6		CAN	Cancer Detection and Diagnosis Research	000	2	8/3/2017	NON-COMPETING CONTINUATION	$398,402
														Subtotal = $398,402

Issue Date FY: 2016 ( Subtotal = $394,335 )
2016	2016	BRITISH COLUMBIA CANCER AGENCY	600 West 10th Avenue	VANCOUVER				CAN	Cancer Detection and Diagnosis Research	000	1	9/14/2016	NEW	$394,335
														Subtotal = $394,335

Grand Total All Awards = $1,633,558

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Integrative miRNA data analysis for clinical cancer genomics

Award Number: U24CA210952

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2022

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer