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COG Biospecimen Bank to Support NCI NCTN (U24)

Award Number: U24CA196173
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/22/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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COG Biospecimen Bank to Support NCI NCTN (U24) - Project Summary The Children’s Oncology Group (COG) is the pediatric clinical trials group of the National Clinical Trials Network (NCTN). Over 90% of United States and Canadian children and adolescents with cancer are treated at COG institutions with no racial, ethnic or geographic bias to registration, allowing for near- population-based clinical, translational and basic research. COG has established a strong track record of collecting and banking tumor and non-diseased biospecimens from patients enrolled in COG-sponsored clinical trials, most of which include randomized treatment questions. The COG Biospecimen Bank (COG Biobank), located within the Biopathology Center (part of the Abigail Wexner Research Institute at Nationwide Children’s Hospital), aims to provide high-quality pediatric and adolescent human malignant biospecimens to the research community. Upon review and approval, biospecimens are prioritized for distribution to the COG investigators defined in the clinical trial protocols. After the needs of the planned research have been addressed, residual (legacy) banked biospecimens can be distributed to other investigators within and outside COG via the NCTN Navigator The COG Group and Biobank Concierges can also facilitate access to COG legacy biospecimens that are not currently uploaded in Navigator. For all biospecimen distribution projects, a feasibility assessment by the COG Biobank and the COG Statistical and Data Management Center (SDMC) is completed prior to proposal submission. This proposal supports the collection, processing, and distribution of biospecimens from patient enrolled on COG-sponsored trials. The Pediatric Division of the Cooperative Human Tissue Network (CHTN) then facilitates the distribution of the approved legacy biospecimens. The COG Biobank seeks to directly promote and support outstanding research in the diagnosis and treatment of pediatric cancer through centralized collection, quality control, storage, and distribution procedures. The COG Biobank will continue efforts to provide the latest biorepository-based technological innovations and best practices, resulting in constant improvements in our operational capabilities, investigator access to biospecimens, investigator satisfaction, and the stewardship of these precious resources. Under proper regulatory guidelines and in association with the COG SDMC, the COG Biobank will support translational aspects of cutting-edge research by ensuring appropriate tracking of biospecimens as well as linkage to existing demographic, clinical, biological, treatment, and outcome data. Finally, the COG Biobank will provide investigators with a comprehensive database solution and dynamic informatics tools that facilitate pediatric cancer research. The COG Biobank also plans to support the processing, banking, and distribution of biospecimens to the Cancer Immune Monitoring and Analysis Centers (CIMACs).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,033,669 )
2025	2025	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	11	4/30/2025	NON-COMPETING CONTINUATION	$3,033,669
2025	2025	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	11	5/12/2025	NON-COMPETING CONTINUATION	$0
2025	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	10	3/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,033,669

Issue Date FY: 2024 ( Subtotal = $6,232,880 )
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	10	4/12/2024	NON-COMPETING CONTINUATION	$2,498,284
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	10	9/6/2024	NON-COMPETING CONTINUATION	$0
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	004	10	9/13/2024	NON-COMPETING CONTINUATION	$3,718,596
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	10	8/27/2024	NON-COMPETING CONTINUATION	$16,000
2024	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	9	11/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,232,880

Issue Date FY: 2023 ( Subtotal = $6,579,096 )
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Treatment Research	005	9	9/18/2023	SUPPLEMENT FOR EXPANSION	$2,900,934
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	9	5/5/2023	NON-COMPETING CONTINUATION	$3,557,162
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	004	9	9/18/2023	NON-COMPETING CONTINUATION	$121,000
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	9	9/8/2023	NON-COMPETING CONTINUATION	$0
2023	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	8	5/5/2023	NON-COMPETING CONTINUATION	$0
2023	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	8	6/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,579,096

Issue Date FY: 2022 ( Subtotal = $5,206,035 )
2022	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	8	4/15/2022	NON-COMPETING CONTINUATION	$3,411,104
2022	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Treatment Research	003	8	9/19/2022	SUPPLEMENT FOR EXPANSION	$1,794,931
2022	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	5	2/25/2022	SUPPLEMENT FOR EXPANSION	-$331
2022	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	6	2/25/2022	COMPETING CONTINUATION	$331
														Subtotal = $5,206,035

Issue Date FY: 2021 ( Subtotal = $7,636,196 )
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	7	5/14/2021	NON-COMPETING CONTINUATION	$3,390,877
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	005	7	9/9/2021	NON-COMPETING CONTINUATION	$4,245,319
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	006	7	9/10/2021	NON-COMPETING CONTINUATION	$0
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	004	7	9/7/2021	NON-COMPETING CONTINUATION	$0
2021	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	5	2/20/2021	SUPPLEMENT FOR EXPANSION	-$566,655
2021	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	6	2/20/2021	COMPETING CONTINUATION	$566,655
2021	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	6	3/29/2021	COMPETING CONTINUATION	$0
														Subtotal = $7,636,196

Issue Date FY: 2020 ( Subtotal = $5,521,187 )
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	5	5/15/2020	SUPPLEMENT FOR EXPANSION	$907,751
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	6	9/11/2020	COMPETING CONTINUATION	$2,105,868
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	6	8/25/2020	COMPETING CONTINUATION	$2,507,568
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	004	6	9/22/2020	COMPETING CONTINUATION	$0
2020	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	5	5/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,521,187

Issue Date FY: 2019 ( Subtotal = $4,277,554 )
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	5	8/2/2019	NON-COMPETING CONTINUATION	$0
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	5	8/8/2019	NON-COMPETING CONTINUATION	$0
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	004	5	8/19/2019	NON-COMPETING CONTINUATION	$0
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	005	5	8/27/2019	NON-COMPETING CONTINUATION	$2,100,000
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	5	3/29/2019	NON-COMPETING CONTINUATION	$2,177,554
2019	2018	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	4	2/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,277,554

Issue Date FY: 2018 ( Subtotal = $2,844,903 )
2018	2018	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	4	9/12/2018	SUPPLEMENT FOR EXPANSION	$600,000
2018	2018	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	4	4/9/2018	NON-COMPETING CONTINUATION	$2,244,903
														Subtotal = $2,844,903

Issue Date FY: 2017 ( Subtotal = $2,244,903 )
2017	2017	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	3	3/14/2017	NON-COMPETING CONTINUATION	$2,020,412
2017	2017	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	3	6/7/2017	NON-COMPETING CONTINUATION	$224,491
														Subtotal = $2,244,903

Issue Date FY: 2016 ( Subtotal = $2,244,903 ) (Continued on the next page)
Grand Total All Awards = $48,729,764

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COG Biospecimen Bank to Support NCI NCTN (U24)

Award Number: U24CA196173

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/22/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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