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NSABP Biological Specimen Banks

Award Number: U24CA114732
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/27/2005
PERIOD OF PERFORMANCE END DATE: 03/31/2015

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NSABP Biological Specimen Banks - DESCRIPTION (provided by applicant): The NSABP has randomized more than 100,000 patients with diagnoses of breast or colorectal cancers into clinical trials during the past 50 years. Based on incremental benefit achieved through multiple evolutionary steps of treatment modalities tested in those trials, significant improvement in patient outcomes has been achieved overall. However, this approach also means that there has been significant over-treatment of some patients who did not benefit from the various interventions, which now have become part of legacy treatments to which newer agents are added. Development of reliable prognostic and predictive tests is required to deliver the goal of more personalized treatment. Since, for ethical reasons, trials cannot be conducted again once the efficacy of newer regimens is demonstrated, archived tumor tissue blocks from historical trials conducted by the NSABP provide an essential resource to investigators who are trying to develop such tests. The NSABP Biospecimen Bank at the NSABP Division of Pathology Tissue Bank houses tumor-tissue specimens from more than 87,000 patients and serves as an open resource to the scientific community to provide tissues for development and clinical validation of new prognostic or predictive tests. Tissue specimens are provided to investigators from both academia and the private sector on the basis of scientific merit. A multi-gene expression based prognostic test (OncotypeDx) developed in a collaboration between the private sector and the bank has become a standard in clinical management of hormone receptor positive node negative breast cancer in the United States. In-house development and/or optimization of methods for whole-genome gene-expression analyses and mutation profiling of formalin-fixed, paraffin-embedded blocks further enhances the value of the NSABP Biospecimen Bank.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $919,823 )
2014	2014	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	8	5/19/2014	SUPPLEMENT FOR EXPANSION	$919,823
														Subtotal = $919,823

Issue Date FY: 2013 ( Subtotal = $764,073 )
2013	2013	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	8	7/1/2013	NON-COMPETING CONTINUATION	$600,365
2013	2013	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	8	3/25/2013	NON-COMPETING CONTINUATION	$163,708
														Subtotal = $764,073

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2012	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	7	8/15/2012	NON-COMPETING CONTINUATION	$0
2012	2010	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	5	11/30/2011	SUPPLEMENT FOR EXPANSION	$0
2012	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	5	11/30/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $1,225,238 )
2011	2011	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	6	9/23/2011	COMPETING CONTINUATION	$877,149
2011	2011	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	5	9/21/2011	SUPPLEMENT FOR EXPANSION	-$728,702
2011	2011	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	5	3/23/2011	SUPPLEMENT FOR EXPANSION	$1,076,791
														Subtotal = $1,225,238

Issue Date FY: 2010 ( Subtotal = $1,471,496 )
2010	2010	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	003	5	9/7/2010	SUPPLEMENT FOR EXPANSION	$1,225,238
2010	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	5	8/30/2010	NON-COMPETING CONTINUATION	$0
2010	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	5	2/17/2010	NON-COMPETING CONTINUATION	$246,258
2010	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	5	2/17/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,471,496

Issue Date FY: 2009 ( Subtotal = $1,225,238 )
2009	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	002	5	3/13/2009	NON-COMPETING CONTINUATION	$978,980
2009	2009	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	003	5	3/24/2009	NON-COMPETING CONTINUATION	$246,258
2009	2008	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	4	10/29/2008	NON-COMPETING CONTINUATION	$0
2009	2008	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	001	4	2/25/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,225,238

Issue Date FY: 2008 ( Subtotal = $1,068,580 )
2008	2008	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	4	4/5/2008	NON-COMPETING CONTINUATION	$1,068,580
														Subtotal = $1,068,580

Issue Date FY: 2007 ( Subtotal = $866,285 )
2007	2007	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	3	5/8/2007	NON-COMPETING CONTINUATION	$866,285
														Subtotal = $866,285

Issue Date FY: 2006 ( Subtotal = $1,070,869 )
2006	2006	NSABP FOUNDATION, INC	4 ALLEGHENY CENTER 5TH FLOOR	PITTSBURGH	PA	15212	ALLEGHENY	USA	Cancer Detection and Diagnosis Research	000	2	3/15/2006	NON-COMPETING CONTINUATION	$1,070,869
														Subtotal = $1,070,869

Grand Total All Awards = $8,611,602

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NSABP Biological Specimen Banks

Award Number: U24CA114732

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/27/2005

PERIOD OF PERFORMANCE END DATE: 03/31/2015

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