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The Chernobyl Tissue Bank - Coordinating Center

Award Number: U24CA082102
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The Chernobyl Tissue Bank -Coordinating Center Abstract The Chernobyl Tissue Bank was established in 1998 to collect, annotate and store biological samples from patients who were exposed in childhood and adolescence to radioiodine in fallout from the Chernobyl accident, and who subsequently have developed thyroid cancer. The bank currently contains material from 4500 patients, and all material is consented for use in research, including genomics. Biological samples are further processed and made available to scientists worldwide for research on the molecular mechanisms underlying development of thyroid cancer. The CTB also facilitates collection of samples for NCI funded epidemiological cohorts studies such as the Ukraine- American cohort. Sample collection is prospective and the CTB now contains a control population, resident in the same geographical areas, who have developed young onset thyroid cancer in the absence of radioiodine exposure, thus facilitating research into identifying biomarkers of radiation in an age- matched cohort. An estimated thyroid dose for each exposed individual is also provided by the CTB. The current application is for continued collection of samples in Ukraine, addition of further clinical data on treatment and outcome and further collation of research data. Recent research in adult thyroid cancer has suggested that addition of biomarkers to clinical annotation provides better risk stratification for patients. The CTB is the largest collection of samples from young onset thyroid cancer and is therefore ideally placed for studies into the role of biomarkers in risk stratification for young onset thyroid cancer. To facilitate this, the CTB is also in the process of collating data from research studies that have used material from the resource. This will enable initial in silico studies to be conducted to identify potential risk stratification biomarkers for validation in further studies. The funds sought in this application are to support the continuation and further development of this unique infrastructure. Elements of the infrastructure have potential for use in other large-scale tissue banking initiatives for cancer research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$67,069 )
2023	2021	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	FACULTY BUILDING SOUTH KENSINGTON C	LONDON				GBR	Cancer Biology Research	001	21	6/1/2023	NON-COMPETING CONTINUATION	-$67,068
2023	2021	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	FACULTY BUILDING SOUTH KENSINGTON C	LONDON				GBR	Cancer Biology Research	000	21	5/15/2023	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$67,069

Issue Date FY: 2021 ( Subtotal = $288,893 )
2021	2021	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	FACULTY BUILDING SOUTH KENSINGTON CAMPUS	LONDON				GBR	Cancer Biology Research	002	21	7/16/2021	NON-COMPETING CONTINUATION	$321,960
2021	2020	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD SOUTH KENSINGTON CAMPUS	LONDON				GBR	Cancer Biology Research	000	20	2/12/2021	NON-COMPETING CONTINUATION	$0
2021	2016	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	FACULTY BUILDING SOUTH KENSINGTON CAMPUS	LONDON				GBR	Cancer Biology Research	001	16	6/21/2021	NON-COMPETING CONTINUATION	-$33,067
														Subtotal = $288,893

Issue Date FY: 2020 ( Subtotal = $252,107 )
2020	2020	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD SOUTH KENSINGTON CAMPUS	LONDON		SW7 2AZ		GBR	Cancer Biology Research	000	20	7/20/2020	NON-COMPETING CONTINUATION	$252,107
														Subtotal = $252,107

Issue Date FY: 2019 ( Subtotal = $260,844 )
2019	2019	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	001	19	7/17/2019	NON-COMPETING CONTINUATION	$260,844
2019	2018	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	000	18	3/22/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $260,844

Issue Date FY: 2018 ( Subtotal = $324,000 )
2018	2018	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	002	18	7/27/2018	NON-COMPETING CONTINUATION	$324,000
2018	2017	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	001	17	1/4/2018	COMPETING CONTINUATION	$1
2018	2016	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	000	16	1/4/2018	NON-COMPETING CONTINUATION	-$1
														Subtotal = $324,000

Issue Date FY: 2017 ( Subtotal = $324,000 )
2017	2017	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE	EXHIBITION ROAD	LONDON		SW7 2AZ		GBR	Cancer Biology Research	000	17	9/14/2017	COMPETING CONTINUATION	$324,000
														Subtotal = $324,000

Issue Date FY: 2016 ( Subtotal = $228,718 )
2016	2016	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	000	16	8/9/2016	NON-COMPETING CONTINUATION	$228,718
														Subtotal = $228,718

Issue Date FY: 2015 ( Subtotal = $249,066 )
2015	2015	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	000	14	4/27/2015	SUPPLEMENT FOR EXPANSION	$5,617
2015	2015	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	001	15	7/28/2015	NON-COMPETING CONTINUATION	$243,449
														Subtotal = $249,066

Issue Date FY: 2014 ( Subtotal = $242,691 )
2014	2014	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	000	14	7/21/2014	NON-COMPETING CONTINUATION	$242,691
														Subtotal = $242,691

Issue Date FY: 2013 ( Subtotal = $242,127 )
2013	2013	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	003	13	8/29/2013	EXTENSION WITH OR WITHOUT FUNDS	$13,127
2013	2013	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	002	13	8/20/2013	EXTENSION WITH OR WITHOUT FUNDS	$229,000
2013	2012	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	001	12	12/4/2012	COMPETING CONTINUATION	$0
2013	2012	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	000	12	10/26/2012	COMPETING CONTINUATION	$0
														Subtotal = $242,127

Issue Date FY: 2012 ( Subtotal = $241,745 )
2012	2012	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	003	12	10/26/2012	COMPETING CONTINUATION	$0
2012	2012	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	002	12	9/19/2012	COMPETING CONTINUATION	$241,745
2012	2011	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	001	11	9/19/2012	NON-COMPETING CONTINUATION	$0
2012	2011	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION ROAD	LONDON				GBR	Cancer Biology Research	000	11	1/19/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $241,745

Issue Date FY: 2011 ( Subtotal = $229,602 )
2011	2011	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	000	11	8/17/2011	NON-COMPETING CONTINUATION	$229,602
														Subtotal = $229,602

Issue Date FY: 2010 ( Subtotal = $231,444 )
2010	2010	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	000	10	9/15/2010	NON-COMPETING CONTINUATION	$231,444
														Subtotal = $231,444

Issue Date FY: 2009 ( Subtotal = $309,715 )
2009	2009	U OF L IMPERIAL COL OF SCI/TECHNLGY/MED	SCIENCE AND TECHNOLOGY EXHIBITION R	LONDON				GBR	Cancer Biology Research	000	9	9/22/2009	NON-COMPETING CONTINUATION	$309,715
														Subtotal = $309,715

Issue Date FY: 2007 ( Subtotal = $43,672 )
2007	2007	UNIVERSITY OF WALES, SWANSEA	Singleton Park	SWANSEA		SA2 8-PP		GBR	Cancer Biology Research	001	7	8/31/2007	SUPPLEMENT FOR EXPANSION	$43,672
														Subtotal = $43,672

Issue Date FY: 2006 ( Subtotal = $236,728 )
2006	2006	UNIVERSITY OF WALES, SWANSEA	Singleton Park	SWANSEA		SA2 8-PP		GBR	Cancer Cause and Prevention Research	000	7	9/1/2006	NON-COMPETING CONTINUATION	$236,728
														Subtotal = $236,728

Issue Date FY: 2004 ( Subtotal = $121,166 )
2004	2004	UNIVERSITY OF WALES, SWANSEA	Singleton Park	SWANSEA		SA2 8-PP		GBR	Cancer Cause and Prevention Research	000	5	9/27/2004	NON-COMPETING CONTINUATION	$121,166
														Subtotal = $121,166

Issue Date FY: 2003 ( Subtotal = $110,575 )
2003	2003	UNIVERSITY OF WALES, SWANSEA	Singleton Park	SWANSEA		SA2 8-PP		GBR	Cancer Cause and Prevention Research	000	4	9/24/2003	COMPETING CONTINUATION	$110,575
														Subtotal = $110,575

Issue Date FY: 2001 ( Subtotal = $146,638 ) (Continued on the next page)
Grand Total All Awards = $4,108,434

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The Chernobyl Tissue Bank - Coordinating Center

Award Number: U24CA082102

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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