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Molecular Transducers of Physical Activity Consortium Coordinating Center

Award Number: U24AR071113
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Molecular Transducers of Physical Activity Consortium Coordinating Center - Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC), composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core provides expertise, personnel, and information technology (IT) solutions to support the organization, administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites (PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board (DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice- chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of Florida and oversees an administrative staff that is the core for managing Consortium-wide communications, setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the DMAQC Core staff providing project management, computing, and analytical support for all other components of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The CCC will continue to employ innovative project management tools, programming, and web-based tracking of recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the outstanding track record in successfully coordinating, managing, and leading large long-term multicenter clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science; (b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g) publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge regarding the molecular transducers of exercise as related to public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,200,000 )
2026	2026	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Common Fund	002	9	7/21/2026	SUPPLEMENT FOR EXPANSION	$1,200,000
2026	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	9	4/30/2026	NON-COMPETING CONTINUATION	$0
2026	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	9	7/22/2026	NON-COMPETING CONTINUATION	$0
2026	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	9	2/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,200,000

Issue Date FY: 2025 ( Subtotal = $1,200,000 )
2025	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	9	8/13/2025	NON-COMPETING CONTINUATION	$1,200,000
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	8	6/12/2025	NON-COMPETING CONTINUATION	$0
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	8	6/3/2025	NON-COMPETING CONTINUATION	$0
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	3/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,200,000

Issue Date FY: 2024 ( Subtotal = $3,000,269 )
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	006	8	9/4/2024	SUPPLEMENT FOR EXPANSION	$200,269
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	8	8/14/2024	NON-COMPETING CONTINUATION	$2,800,000
2024	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	003	6	1/8/2024	SUPPLEMENT FOR EXPANSION	-$65,129
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	7	1/8/2024	COMPETING CONTINUATION	$1,455,225
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	7	2/16/2024	COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	6	1/8/2024	NON-COMPETING CONTINUATION	-$1
2024	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	1/8/2024	NON-COMPETING CONTINUATION	-$1,390,095
														Subtotal = $3,000,269

Issue Date FY: 2023 ( Subtotal = $3,165,131 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	006	6	8/17/2023	SUPPLEMENT FOR EXPANSION	$65,129
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	009	7	9/22/2023	COMPETING CONTINUATION	$0
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	008	7	9/21/2023	COMPETING CONTINUATION	$3,100,000
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	003	6	6/15/2023	NON-COMPETING CONTINUATION	$1
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	6	11/28/2022	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	005	6	6/27/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	6	2/23/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	007	6	9/21/2023	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	5	6/27/2023	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	5	6/14/2023	NON-COMPETING CONTINUATION	$1
														Subtotal = $3,165,131

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	003	6	7/21/2022	NON-COMPETING CONTINUATION	$2,896,620
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	005	6	9/1/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	004	6	8/15/2022	NON-COMPETING CONTINUATION	-$2,896,620
2022	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	5	3/2/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	5	5/11/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	002	5	7/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,927,716 )
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	5	6/4/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	5	12/28/2020	NON-COMPETING CONTINUATION	$2,927,716
														Subtotal = $2,927,716

Issue Date FY: 2020 ( Subtotal = $2,671,620 )
2020	2020	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	4	2/27/2020	NON-COMPETING CONTINUATION	$2,671,620
2020	2020	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	4	7/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,671,620

Issue Date FY: 2019 ( Subtotal = $8,248,259 )
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	3	4/4/2019	NON-COMPETING CONTINUATION	$102,107
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	003	3	9/26/2019	NON-COMPETING CONTINUATION	$5,855,000
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	3	3/16/2019	NON-COMPETING CONTINUATION	$2,291,152
2019	2019	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	002	3	6/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,248,259

Issue Date FY: 2018 ( Subtotal = $5,614,654 )
2018	2018	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	001	2	9/12/2018	NON-COMPETING CONTINUATION	$3,778,249
2018	2018	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Trans-NIH Research Support	000	2	2/28/2018	NON-COMPETING CONTINUATION	$1,836,405
														Subtotal = $5,614,654

Grand Total All Awards = $28,848,731

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Molecular Transducers of Physical Activity Consortium Coordinating Center

Award Number: U24AR071113

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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