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SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging

Award Number: U24AG067418
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging - PROJECT SUMMARY This overall goal of this application is to create an infrastructure for supporting and augmenting neuroimaging research in the National Institute of Aging’s Alzheimer’s Disease Centers (ADC) Program. The ADC program is comprised of 30 centers that pursue research goals dedicated to increasing our understanding of Alzheimer’s disease (AD) with a view towards improving diagnosis, care, and treatment of patients. Over the past decade, neuroimaging has played an increasingly important role in this mission, as new approaches to measuring brain structure, function, and biochemistry have produced biomarkers useful in diagnostic, mechanistic, and therapeutic studies. At the same time, methods for standardization of neuroimaging have become accepted, such that, despite the complexity and cost of imaging, we have the ability to combine images obtained at different centers in order to answer important questions about AD that require large datasets. This project will focus on standardizing approaches to magnetic resonance imaging (MRI) and positron emission tomography (PET) images. MR standardization will address structural and functional (task-free) MRI, and PET standardization will address amyloid, tau, and glucose metabolic imaging. We will work with the National Alzheimer’s Coordinating Center (NACC) to develop protocols for securely uploading and de-identifying all images at a NACC image repository, where a searchable database will also be available to researchers. We will develop standards for MR and PET image acquisition, and make these imaging protocols available to the ADC community. Uploaded images will undergo rigorous quality control and processing to permit merging of images obtained on different platforms and, for PET, at different resolutions. Laboratories that have specialized in image processing will produce numerical summary data of brain cerebrovascular pathology, brain volumes, perfusion, diffusion, and cortical thickness, amyloid and tau deposition, and glucose metabolism. These numerical variables will be stored at NACC where it will be linked to other ADC-related data on participants and made available to researchers. Additional aspects of the program will include a website with documentation, search functions, and user help functions. The administrative structure of the project will involve an executive committee with membership from the participating laboratories as well as representation from the NACC, the ADCs, and NIA. Leadership will remain apprised of changes in the neuroimaging landscape, and incorporate new MR and PET measures as they develop with the overall goal of standardizing and disseminating agreed- upon best practices while not stifling the development of new, innovative technical advances.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,580,400 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	5	7/28/2025	NON-COMPETING CONTINUATION	$1,580,400
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	4	3/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,580,400

Issue Date FY: 2024 ( Subtotal = $1,590,871 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	4	5/16/2024	NON-COMPETING CONTINUATION	$1,590,871
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	3	2/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,590,871

Issue Date FY: 2023 ( Subtotal = $2,184,642 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	002	3	5/17/2023	SUPPLEMENT FOR EXPANSION	$582,629
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	3	5/12/2023	NON-COMPETING CONTINUATION	$1,602,013
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	2	1/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,184,642

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	2	6/9/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	2	6/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,244,925 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	2	6/24/2021	SUPPLEMENT FOR EXPANSION	$641,593
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	2	4/30/2021	NON-COMPETING CONTINUATION	$1,603,332
														Subtotal = $2,244,925

Issue Date FY: 2020 ( Subtotal = $1,657,167 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	1	4/16/2020	NEW	$1,657,167
														Subtotal = $1,657,167

Grand Total All Awards = $9,258,005

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SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging

Award Number: U24AG067418

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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