Wednesday, August 20, 2025 8/20/2025

Integrative Resource to Develop Translational Strategies to Promote Longevity

Award Number: U24AG051129
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2023

Group Awards By:

View Award Description

Integrative Resource to Develop Translational Strategies to Promote Longevity - DESCRIPTION (provided by applicant): Human longevity is heritable, and statistically and biologically compelling genetic associations with longevity and age-related traits in humans have been identified. The translation of these genetic associations into insights that can lead to pharmacological interventions designed to promote healthy aging requires an approach and infrastructure that integrates many sources of information and scientific expertise. In fact, a previous inability to translate insights from genetic associations to longevity-promoting interventions is due, at least in part, to a lack of well-integrated and assembled research teams with expertise in all areas of relevance. We propose the creation of a resource and infrastructure that integrates genomic and related data sources that enable our diverse scientific team to develop strategies for identifying targets for pharmacological intervention that will impact longevity based on genetic associations. This infrastructure will include information from longitudinal cohort studies with genome-wide genotype and sequencing data, computational methods for annotating genetic variants, information from tissue-specific studies of expression quantitative trait loci (eQTL), and datasets of chemical properties of small molecule compounds linked to protein targets. Our scientific team includes experts in human and model organism aging, genetic epidemiology of aging, statistical genetics, chemical informatics, and pharmaceutical development. We will also assemble a research planning committee that will meet annually to evaluate the evidence from our statistical analyses and to develop plans for pilot projects to advance the translation of our findings into health-promoting therapeutics. A central theme in our proposal is to develop insights relating molecular and physiologic factors that can be manipulated pharmacologically to healthy aging based on hypothesis rooted in genetic associated studies involving longevity. We will identify candidate genetic variants for in-depth analysis by meta-analyzing results from published genome-wide association studies (GWAS) of longevity and age-related traits and by searching for evidence of genetic variants with pleiotropic effects on aging-related traits. Genes likely to be modulated by candidate genetic variants will be identified using genomic functional annotation resources such as tissue-specific genomic functional elements and eQTLs. For each identified gene, an allelic series of genetic variants associated with, e.g., the expression of that gene, will be identified from eQTL data sets, and a genetic risk score constructed from the allelic series will be tested for its association with longitudinal measures of aging, including incident disability, incident disease and chronic conditions, and change in physical and cognitive function, which can build the foundation for the search for small molecule compounds that might mimic the collective effect of selected genetic variants. By identifying small molecules based on therapeutic hypotheses relating genetic function to healthy aging, effective translational research strategies can be developed and disseminated to the research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$83,520 )
2024	2019	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	5	12/29/2023	NON-COMPETING CONTINUATION	-$83,520
														Subtotal = -$83,520

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	SUTTER BAY HOSPITALS	475 BRANNAN ST STE 130	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	5	5/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	5	4/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	5	11/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $911,738 )
2019	2019	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	5	4/3/2019	NON-COMPETING CONTINUATION	$911,738
														Subtotal = $911,738

Issue Date FY: 2018 ( Subtotal = $1,453,473 )
2018	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	4	9/11/2018	SUPPLEMENT FOR EXPANSION	$518,104
2018	2018	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	4	8/24/2018	NON-COMPETING CONTINUATION	$935,369
2018	2017	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	3	4/18/2018	NON-COMPETING CONTINUATION	$0
2018	2017	SUTTER BAY HOSPITALS	633 FOLSOM ST FL 5	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	3	8/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,453,473

Issue Date FY: 2017 ( Subtotal = $963,198 )
2017	2017	SUTTER BAY HOSPITALS	633 FOLSOM STREET 5TH FLOOR	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	3	8/1/2017	NON-COMPETING CONTINUATION	$963,198
														Subtotal = $963,198

Issue Date FY: 2016 ( Subtotal = $988,213 )
2016	2016	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	2	5/26/2016	NON-COMPETING CONTINUATION	$988,213
														Subtotal = $988,213

Issue Date FY: 2015 ( Subtotal = $1,000,000 )
2015	2015	CALIFORNIA PACIFIC MEDICAL CENTER	2340 CLAY STREET, 5TH FL	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Aging Research	000	1	9/5/2015	NEW	$1,000,000
														Subtotal = $1,000,000

Grand Total All Awards = $5,233,102

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Integrative Resource to Develop Translational Strategies to Promote Longevity

Award Number: U24AG051129

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer