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1/11 Integrative Neuroscience Initiative on Alcoholism

Award Number: U24AA025479
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2017
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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1/11 Integrative Neuroscience Initiative on Alcoholism - PROJECT SUMMARY This is a competing renewal application for the Integrative Neuroscience Initiative on Alcoholism (INIA)- Neuroimmune consortium (Notice# RFA-AA-20-011, RFA-AA-20-013) to integrate multidisciplinary research projects based on the genomic, cellular, and behavioral neuroadaptations related to excessive alcohol consumption. This consortium has identified gene networks and pathways associated with excessive alcohol drinking in humans and animals and focuses on potential drug targets within neuroimmune and neuroinflammatory signaling pathways. In the next phase of this initiative, our collective proposals will address several documented NIAAA goals which include: 1) understanding the genomics, electrophysiology, and pharmacology of brain immune signaling systems in neurons and glial cells and their role in causes and treatments of alcohol dependence; 2) using new technologies such as single cell and spatial transcriptomics, proteomics, and multimodal functional and structural imaging to study these systems; 3) promoting reproducibility and translation of data through testing in multiple laboratories and in multiple assays; 4) guiding investigators in determining the translatability of their findings for preclinical and clinical studies by NIAAA- supported units outside the consortium. The overall hypothesis for INIA-N is that systematic analysis of neuroimmune mechanisms will inform strategies for treatment of excessive drinking associated with Alcohol Use Disorder. Ten Research Components and an Administrative Core comprise the consortium. INIA-N will be directed by the Administrative Core in cooperation with the Executive and Steering Committees and guided by a distinguished Scientific Advisory Board. The Administrative Core will provide leadership, oversight of scientific projects, and integration and translation of project data. INIA-N has six goals: 1) expand gene expression datasets with results from single nuclei sequencing and spatial transcriptomics to generate cell-type specific and anatomical transcriptome maps and integrate human cellular transcriptome data with human genome wide association studies; 2) define the contribution of specific non-neuronal cell types (astrocytes and microglia) to the molecular and behavioral effects of excessive alcohol consumption through a collaborative investigation of immune related cells of the brain; 3) examine alcohol-induced changes in perineuronal nets and in the abundance and post-translational modifications of extracellular matrix proteins as mechanisms for glial-neuronal cross talk that impact brain circuits regulating alcohol consumption; 4) pursue biochemical and electrophysiological studies of cytokine signaling to understand innate immune mechanisms by which excessive alcohol consumption changes brain function; 5) apply systems-level, connectomics approaches to identify mechanisms by which excessive alcohol consumption changes whole brain function, with emphasis on the role of our top neuroimmune genes; and 6) propose and prioritize drug targets and compounds for advancement to testing in animals and in humans by NIAAA supported entities outside the INIA-N consortium.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $422,250 )
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	9	3/20/2025	NON-COMPETING CONTINUATION	$422,250
														Subtotal = $422,250

Issue Date FY: 2024 ( Subtotal = $531,933 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	8	5/21/2024	NON-COMPETING CONTINUATION	$53,193
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	8	1/23/2024	NON-COMPETING CONTINUATION	$478,740
														Subtotal = $531,933

Issue Date FY: 2023 ( Subtotal = $511,485 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	7	6/7/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	7	2/1/2023	NON-COMPETING CONTINUATION	$511,485
														Subtotal = $511,485

Issue Date FY: 2022 ( Subtotal = $568,363 )
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	6	3/22/2022	COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	003	6	6/15/2022	COMPETING CONTINUATION	$11,759
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	6	2/9/2022	COMPETING CONTINUATION	$568,363
2022	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	002	5	6/15/2022	NON-COMPETING CONTINUATION	-$11,759
														Subtotal = $568,363

Issue Date FY: 2021 ( Subtotal = $481,012 )
2021	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	5	1/18/2021	NON-COMPETING CONTINUATION	$481,012
														Subtotal = $481,012

Issue Date FY: 2020 ( Subtotal = $481,012 )
2020	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	4	1/22/2020	NON-COMPETING CONTINUATION	$481,012
														Subtotal = $481,012

Issue Date FY: 2019 ( Subtotal = $481,012 )
2019	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	3	1/24/2019	NON-COMPETING CONTINUATION	$481,012
														Subtotal = $481,012

Issue Date FY: 2018 ( Subtotal = $481,012 )
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	2	1/31/2018	NON-COMPETING CONTINUATION	$432,912
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	001	2	5/25/2018	NON-COMPETING CONTINUATION	$48,100
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	002	2	8/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $481,012

Issue Date FY: 2017 ( Subtotal = $481,012 )
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Alcohol Research Programs	000	1	2/1/2017	NEW	$481,012
														Subtotal = $481,012

Grand Total All Awards = $4,439,091

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1/11 Integrative Neuroscience Initiative on Alcoholism

Award Number: U24AA025479

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2017

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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