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Integrative Analysis of Lung Cancer Etiology and Risk

Award Number: U19CA203654
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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View Award Description

Integrative Analysis of Lung Cancer Etiology and Risk - Project Summary/Abstract Lung cancer is the leading cause of cancer worldwide. The mortality rate represents over 25% of all cancers deaths, four times the number of breast cancer deaths in the U.S. Despite substantial improvements in the treatment of lung cancer, its prognosis remains dismal, with a current 5-year mortality of approximately 85%, in large part because it is usually diagnosed at stage III or IV. This high lung cancer burden reflects how ubiquitous are exposures to tobacco smoke and other behaviorally influenced factors. These exposures, along with poor adoption of screening and cancer control approaches, impedes improvements in survival. Management of lung cancer risk can be accomplished at all steps of the cancer prevention continuum, starting with primary prevention, primarily by modifying smoking behavior. After the development of lung cancer, early detection dramatically reduces mortality but compliance with existing guidelines for screening is poor. Furthermore, the majority of lung cancers that will develop occur among the population that is ineligible for screening. Finally, even among those who are screened, a large number of positive findings are detected and improved approaches to resolving high versus low-risk findings are needed to reduce the burden of excess management and overdiagnosis. Our program project, entitled ‘Integrative Analysis of Lung Cancer Risk and Etiology (INTEGRAL)-Applications and Translation is broadening our studies to identify predictive risk factors in minority populations and among never smokers. Our aims are the following. Aim 1: To use genomic predictors to identify individuals who are at higher risk for lung cancer development. This aim focuses on developing and applying methods for risk assessment in diverse populations, Aim 2: To develop and implement novel biomarkers that identify individuals who are at elevated lung cancer risk and will benefit from low dose spiral CT screening. This aim extends our prior research to identify risks for nonsmokers and evaluate the translation of biomarker studies for population-based research. Aim 3: To evaluate predictors of lung cancer detection and progression based on an integrative analysis of data from screening populations. This aim evaluates new approaches to integrative analysis of biomarker and radiographic marker studies in screening populations. Aim 4: To implement novel frameworks to manage risk reduction at all stages of lung cancer development and management. This aim cuts across projects and evaluates the barriers and interests of populations who will benefit from the research being conducted by this P01. This proposal builds upon a highly successful prior program project to broaden the populations we are studying and engage and translate the findings to diverse populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,627,059 )
2026	2026	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Cause and Prevention Research	003	10	7/17/2026	SUPPLEMENT FOR EXPANSION	$498,872
2026	2026	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Cause and Prevention Research	002	10	7/8/2026	NON-COMPETING CONTINUATION	$1,627,632
2026	2026	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Cause and Prevention Research	004	10	7/18/2026	SUPPLEMENT FOR EXPANSION	$500,555
2026	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	8	1/7/2026	NON-COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Cause and Prevention Research	001	9	2/24/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $2,627,059

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	8	4/17/2025	NON-COMPETING CONTINUATION	-$2,656,017
2025	2024	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Cancer Cause and Prevention Research	001	9	4/17/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,656,017
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,729,927 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	003	8	9/9/2024	NON-COMPETING CONTINUATION	$2,729,927
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	7	10/18/2023	COMPETING CONTINUATION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	7	11/9/2023	COMPETING CONTINUATION	$0
2024	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	002	6	9/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,729,927

Issue Date FY: 2023 ( Subtotal = $2,910,518 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	002	7	9/25/2023	COMPETING CONTINUATION	$2,910,518
2023	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	6	9/25/2023	NON-COMPETING CONTINUATION	$0
2023	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	6	1/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,910,518

Issue Date FY: 2022 ( Subtotal = $2,234,679 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	6	4/25/2022	NON-COMPETING CONTINUATION	$2,234,679
2022	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	5	1/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,234,679

Issue Date FY: 2021 ( Subtotal = $2,562,113 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	5	3/18/2021	NON-COMPETING CONTINUATION	$2,334,007
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	002	5	7/2/2021	SUPPLEMENT FOR EXPANSION	$228,106
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	4	12/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,562,113

Issue Date FY: 2020 ( Subtotal = $2,605,399 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	4	3/31/2020	NON-COMPETING CONTINUATION	$2,293,303
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	003	4	8/14/2020	NON-COMPETING CONTINUATION	$239,606
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	002	4	6/25/2020	NON-COMPETING CONTINUATION	$72,490
2020	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	3	12/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,605,399

Issue Date FY: 2019 ( Subtotal = $2,306,176 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	3	5/17/2019	NON-COMPETING CONTINUATION	$2,306,176
2019	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	000	2	1/25/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $2,306,176

Issue Date FY: 2018 ( Subtotal = $270,790 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	004	2	8/23/2018	SUPPLEMENT FOR EXPANSION	$147,830
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	006	2	9/21/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$62,043
2018	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Cause and Prevention Research	002	1	5/22/2018	NEW	-$32,657
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	001	2	4/25/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,660,550
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	003	2	5/22/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$32,657
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Cause and Prevention Research	005	2	9/13/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$60,919
2018	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Cause and Prevention Research	000	1	4/25/2018	NEW	-$2,660,552
														Subtotal = $270,790

Issue Date FY: 2017 ( Subtotal = $2,833,706 )
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Cause and Prevention Research	000	1	6/29/2017	NEW	$2,833,706
														Subtotal = $2,833,706

Grand Total All Awards = $21,080,367

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Integrative Analysis of Lung Cancer Etiology and Risk

Award Number: U19CA203654

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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