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West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR)

Award Number: U19AI181594
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/22/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR) - OVERALL RESEARCH STRATEGY ABSTRACT/SUMMARY Despite significant progress to reduce global malaria incidence and related deaths over the past 20 years, this positive trend is now in a state of decline. Data from 2021 indicated that the global milestones set out in WHO's global technical strategy for malaria 2016-30 (GTS) were not met, with both case and mortality targets being off track by 48%. Increasing insecticide and drug resistance, limited sensitivity of field diagnostic tools, and declining investments are urgent contributory factors to the decline in coverage and effectiveness of routine control interventions. To date, the true contribution of non-falciparum malaria (NFM) – often presenting as asymptomatic infection – to the global disease burden remains underappreciated. While P. vivax (Pv) has risen in research priority over the past 10 years, research into the fundamental epidemiology and transmission dynamics of P. ovale (Po wallikeri [Pow] and Po curtisi [Poc]) and P. malariae (Pm) has been largely neglected. Quantifying the asymptomatic malaria reservoir in human populations has been a priority topic for current ICEMR programs, yet deeper insight into this issue is elusive. The West- Central Africa Enhancing Malaria Epidemiology Research through Genomics & Translational Systems biology (Émergents [fr.]) ICEMR program leverages successful, wellestablished collaborations, unique advanced research and training infrastructures, and an extensive Sub- Saharan Africa (SSA) research network to address emerging and challenging issues in malaria transmission in the region. This Émergents ICEMR program will focus research in Nigeria and Cameroon, proposing three interwoven programmatic packages (PP): PP1. Genomic Epidemiological Mapping (GEM) of non-falciparum malaria (NFM; Pv, Po, and P. malariae [Pm]) to quantify the parasite reservoir, measure transmissibility to mosquitoes, and evaluate the insecticide resistance status of mosquitoes with NFM parasite infections; PP2. Bionomics, Ecology, & Control of An. stephensi (BECA) against the background of endemic primary and secondary anopheline vectors; PP3. Advancing Clinical and Entomological Surveillance (ACES) through emergent diagnostic and translational systems biology platforms to address emerging issues viz. asymptomatic malaria and non-falciparum malaria transmission in the context of Malaria Elimination and Eradication (MEE). Taken together, the Émergents ICEMR will (a) increase American prosperity by providing jobs at US universities to US-trained doctoral students and postdoctoral trainees as well as offer opportunities for patents, (b) strengthen US leadership and influence in the field, and (c) enhance security by developing enabling tools to tackle key public health threats posed by malaria before this disease is reintroduced into the country.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $747,123 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	002	3	6/12/2026	SUPPLEMENT FOR EXPANSION	$187,145
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	001	3	6/12/2026	SUPPLEMENT FOR EXPANSION	$195,129
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	000	3	6/1/2026	NON-COMPETING CONTINUATION	$364,849
														Subtotal = $747,123

Issue Date FY: 2025 ( Subtotal = $747,123 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	000	2	4/16/2025	NON-COMPETING CONTINUATION	$747,123
														Subtotal = $747,123

Issue Date FY: 2024 ( Subtotal = $747,123 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	002	1	9/16/2024	NEW	$0
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	001	1	7/25/2024	NEW	$0
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Allergy and Infectious Diseases Research	000	1	4/22/2024	NEW	$747,123
														Subtotal = $747,123

Grand Total All Awards = $2,241,369

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West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR)

Award Number: U19AI181594

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/22/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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