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Understanding and Targeting the Barriers to Effective Malaria Control and Elimination in the Asia-Pacific Region

Award Number: U19AI129392
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project summary Overall, the Asia-Pacific region has achieved impressive reductions in malaria over the last 20 years. However, our current Asia-Pacific ICEMR (2017-2024) has documented strongly diverging regional malaria trends: Cambodia is nearing P. falciparum (Pf) elimination but is confronted with the challenge of stubbornly resilient residual P. vivax (Pv) transmission while Papua New Guinea (PNG) recorded 1.2 million new cases in 2021. Despite their differing progress, both countries face common challenges: optimal allocation of sparse resources in heterogeneous transmission settings driven by asymptomatic infections, environmental change affecting malaria transmission, emerging drug and insecticide resistance and the specific the challenge of eliminating Pv. The renewed Asia-Pacific ICEMR will address these challenges by conducting research that applies new techniques and approaches to achieve translational outcomes. We will i) develop and validate optimised surveillance and response systems that combine traditional epidemiological and vector surveillance with targeted reactive population surveys; ii) understand key drivers of ongoing Pv transmission in a wide range of transmission intensity settings and identify locally optimal combinations of interventions to restrict and eventually interrupt transmission; iii) generate evidence on the ability of novel tools and interventions to improve access to Pv radical cure and target the asymptomatic Pv reservoir; and iv) Determine the threat of emerging drug and insecticide resistance. The renewed ICEMR proposes a coordinated set of field, laboratory and modelling studies across 5 sites including a very low transmission site in Cambodia and 4 low, medium and high transmission PNG sites. In the Epidemiology Project, health facility surveillance, cross-sectional, and reactive case detection studies augmented by novel molecular, genomic and serological diagnostic assays will be used to accurately measure malaria transmission and identify key drivers of residual transmission. Through in-depth molecular surveillance and efficacy monitoring we will map the spread Pf artemisinin resistance (ArtR) in PNG and confirm the emergence of Pv ArtR and mefloquine resistance in Cambodia, while conducting coordinated studies to address barriers to increased access and efficacy of Pv radical cure. The Transmission Project will conduct in-depth vector surveillance coupled with vector genetic studies to better understand the epidemiological observations in Project 1, map the recent emergence of pyrethroid resistance in PNG, document vector range expansions due to the accelerating impacts of climate and land-use change, assess the decreasing effectiveness of vector control tools, investigate factors facilitating asymptomatic Pv transmission and evaluate novel transmission blocking interventions. These studies will use innovative diagnostic tests and inform state-of-the-art malaria transmission models provided by two Technical Cores. Throughout the research program policy-relevant scenario modelling will be used determine locally optimal combinations of interventions. Together, these studies will provide malaria programs with accurate and timely data for action and new solutions to accelerate malaria elimination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $662,935 )
2024	2024	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE				AUS	Allergy and Infectious Diseases Research	000	9	6/6/2024	COMPETING CONTINUATION	$662,935
														Subtotal = $662,935

Issue Date FY: 2023 ( Subtotal = $628,037 )
2023	2023	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	001	8	3/28/2023	NON-COMPETING CONTINUATION	$628,037
2023	2023	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	002	8	8/24/2023	NON-COMPETING CONTINUATION	$0
2023	2022	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	000	7	1/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $628,037

Issue Date FY: 2022 ( Subtotal = $622,381 )
2022	2022	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	000	7	4/12/2022	NON-COMPETING CONTINUATION	$622,381
2022	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	001	4	9/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $622,381

Issue Date FY: 2021 ( Subtotal = $622,427 )
2021	2021	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	002	6	5/18/2021	NON-COMPETING CONTINUATION	$622,427
2021	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	003	4	9/24/2021	NON-COMPETING CONTINUATION	-$215,718
2021	2020	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	001	5	3/18/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$345,824
2021	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	000	4	3/18/2021	NON-COMPETING CONTINUATION	-$345,824
2021	2020	THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH	1G ROYAL PDE	PARKVILLE	VIC			AUS	Allergy and Infectious Diseases Research	004	5	9/24/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$215,718
														Subtotal = $622,427

Issue Date FY: 2020 ( Subtotal = $664,129 )
2020	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	001	4	3/30/2020	NON-COMPETING CONTINUATION	$664,129
2020	2019	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	000	3	11/26/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $664,129

Issue Date FY: 2019 ( Subtotal = $614,962 )
2019	2019	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	001	3	3/14/2019	NON-COMPETING CONTINUATION	$614,962
2019	2018	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	000	2	11/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $614,962

Issue Date FY: 2018 ( Subtotal = $621,027 )
2018	2018	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	000	2	3/28/2018	NON-COMPETING CONTINUATION	$621,027
														Subtotal = $621,027

Issue Date FY: 2017 ( Subtotal = $690,181 )
2017	2017	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	000	1	4/28/2017	NEW	$690,181
														Subtotal = $690,181

Grand Total All Awards = $5,126,079

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Understanding and Targeting the Barriers to Effective Malaria Control and Elimination in the Asia-Pacific Region

Award Number: U19AI129392

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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