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ICEMR-Mali : Multidisciplinary research for malaria control and prevention in West Africa

Award Number: U19AI129387
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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SUMMARY Wide deployment of malaria control tools in the past decade has significantly contributed to substantial reduction of the incidence and deaths related to the disease in Sub-Sahara Africa.. Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The Overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa through research to understand interactions between the parasite (response to drug treatment, genotypes, gametocyte survival), human (immune response and host genetics) and the vector (ecology, behaviors, and response to insecticides) and regulating influences of the local environment and human behavior. This ICEMR encompasses 3 Projects with the goals summarized as follow: 1] Epidemiology Project (Project 1): The goal is to understand why different patterns of malaria epidemiology and endemicity are resilient to current control strategies at four sites in Mali, representing different eco-zones across West Africa, 2] Malaria immuno- genomics Project (Project 2): The goal of this project is to identify genetic variation in the malaria parasite and human host, and assess the impact of these differences on malaria transmission and effectiveness of malaria control measures in four sites of Mali , 3] Malaria vector and transmission field ecology project (Project 3): The project goal is to investigate important neglected aspects of malaria vector and transmission field ecology at four sites in Mali, representing three eco-zones across West Africa. These projects links the different aspects of malaria transmission and disease into a unified whole, adding the ability to distinguish the contributions of different malaria control interventions on parasite population and range of immune responses (Project 2, Immunopahtogenesis) and seasonal and geographical distribution of anopheline mosquitoes vectors (Project 3). Understanding the factors relating entomological and epidemiological patterns of transmission will provide more definitive guidelines for malaria control efforts in Mali and in West Africa.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $432,400 )
2022	2022	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	6	3/11/2022	NON-COMPETING CONTINUATION	$432,400


Issue Date FY: 2021 ( Subtotal = $1,381,784 )
2021	2021	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	3/31/2021	NON-COMPETING CONTINUATION	$432,400
2021	2021	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	002	5	8/13/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	001	5	6/1/2021	NON-COMPETING CONTINUATION	$949,384


Issue Date FY: 2020 ( Subtotal = $885,210 )
2020	2020	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	4	3/26/2020	NON-COMPETING CONTINUATION	$885,210


Issue Date FY: 2019 ( Subtotal = $1,431,372 )
2019	2019	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	001	3	4/12/2019	SUPPLEMENT FOR EXPANSION	$458,810
2019	2019	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	002	3	6/27/2019	NON-COMPETING CONTINUATION	$525,690
2019	2019	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	3	3/12/2019	NON-COMPETING CONTINUATION	$446,872


Issue Date FY: 2018 ( Subtotal = $447,012 )
2018	2018	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	2	3/20/2018	NON-COMPETING CONTINUATION	$447,012


Issue Date FY: 2017 ( Subtotal = $680,416 )
2017	2017	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	1	4/18/2017	NEW	$680,416


Grand Total All Awards = $5,258,194

Sum of Action Amount is $5,258,194;

Grand Total = $5,258,194

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ICEMR-Mali : Multidisciplinary research for malaria control and prevention in West Africa

Award Number: U19AI129387

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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