Wednesday, January 15, 2025 1/15/2025

Regulation of B cell Responses in SLE and Other Autoimmune Diseases

Award Number: U19AI110483
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The overarching objective of the Emory Autoimmunity Center of Excellence (ACE) U19 is to decipher the molecular programs responsible for the aberrant B cell responses underpinning autoimmune diseases. A central tenet of the Emory ACE is that unraveling the heterogeneity of human autoimmune diseases and translating that knowledge into mechanistically based treatments requires an integrated collaboration between physician-scientists, basic scientists, and expert clinicians with access to large populations of well-characterized autoimmune patients. Our fundamental goals are: (1) to understand B cell dysregulation in SLE using single cell interrogation of their molecular roadmaps, and (2) to assemble a scientific and technological platform that engages other ACE U19 and UM1 Centers through the Collaborative Project to perform similar studies in other immune cells and autoimmune disorders. These goals will be realized through a highly integrated collaboration between the three components of the Scientific Program supported by an Administrative Core. In the Principal Project, Dr. Sanz will ascertain the heterogeneity of effector B cells, their regulatory programs, and their differential utilization according to disease endotypes, and investigate the diversity and regulation of SLE memory cells. Specifically, his group will analyze germinal center dependent and independent memory and the role of antigenic persistence in the regulation of autoimmune and protective memory. In the Collaborative Project, Dr. Boss will investigate the epigenetic regulation of B cells and other immune cells in SLE and other human autoimmune diseases as part of the Collaborative Agenda that will be developed within the new ACE centers. Finally, in the Pilot Project, Dr. Scharer will pursue the functional characterization of SLE B cell differentiation using high-throughput loss-of-function and gain-of- function CRISPR screens. The Emory ACE also proposes to continue to manage the ACE Funds Management Core and to establish a centralized ACE Biorepository Core to coordinate the collection, storage, and management of samples from the Emory ACE and ACE Clinical Projects and their allocation for use in mechanistic studies. Collectively, the work proposed should contribute greatly to the charter mission and goals of the Autoimmunity Centers of Excellence Network.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $4,394,852 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	11	7/30/2024	COMPETING CONTINUATION	$1,139,783
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	11	9/11/2024	COMPETING CONTINUATION	$115,104
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	11	5/23/2024	COMPETING CONTINUATION	$0
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	11	5/8/2024	COMPETING CONTINUATION	$3,139,965
2024	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	8	1/26/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,394,852

Issue Date FY: 2023 ( Subtotal = $6,250,527 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	10	7/14/2023	NON-COMPETING CONTINUATION	$1,401,368
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	10	5/26/2023	NON-COMPETING CONTINUATION	$0
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	10	5/2/2023	NON-COMPETING CONTINUATION	$4,849,159
2023	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	9	5/26/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	8	5/19/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	8	5/19/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $6,250,527

Issue Date FY: 2022 ( Subtotal = $4,944,875 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	9	8/29/2022	NON-COMPETING CONTINUATION	$0
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	9	5/19/2022	SUPPLEMENT FOR EXPANSION	$46,256
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	9	5/11/2022	NON-COMPETING CONTINUATION	$4,808,545
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	9	5/23/2022	SUPPLEMENT FOR EXPANSION	$88,782
2022	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	8	6/15/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	8	5/18/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2018	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	006	5	9/26/2022	NON-COMPETING CONTINUATION	$1,292
														Subtotal = $4,944,875

Issue Date FY: 2021 ( Subtotal = $33,802,880 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	006	8	8/27/2021	SUPPLEMENT FOR EXPANSION	$26,794,157
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	8	7/21/2021	SUPPLEMENT FOR EXPANSION	$171,686
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	8	6/15/2021	NON-COMPETING CONTINUATION	$671,918
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	8	7/6/2021	NON-COMPETING CONTINUATION	$0
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	8	7/6/2021	SUPPLEMENT FOR EXPANSION	$374,678
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	8	7/2/2021	SUPPLEMENT FOR EXPANSION	$560,943
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	8	8/12/2021	NON-COMPETING CONTINUATION	$5,229,498
														Subtotal = $33,802,880

Issue Date FY: 2020 ( Subtotal = $6,717,101 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	7	7/6/2020	SUPPLEMENT FOR EXPANSION	$525,608
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	7	4/22/2020	NON-COMPETING CONTINUATION	$838,260
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	7	9/11/2020	NON-COMPETING CONTINUATION	$4,229,202
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	7	8/26/2020	SUPPLEMENT FOR EXPANSION	$1,124,031
2020	2019	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	6	1/14/2020	COMPETING CONTINUATION	$1,292
2020	2018	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	5	1/14/2020	NON-COMPETING CONTINUATION	-$1,292
														Subtotal = $6,717,101

Issue Date FY: 2019 ( Subtotal = $5,194,108 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	6	8/30/2019	COMPETING CONTINUATION	$4,229,202
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	6	6/6/2019	COMPETING CONTINUATION	$0
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	6	6/3/2019	COMPETING CONTINUATION	$457,908
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	6	4/17/2019	COMPETING CONTINUATION	$506,998
														Subtotal = $5,194,108

Issue Date FY: 2018 ( Subtotal = $435,020 )
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	5	3/6/2018	NON-COMPETING CONTINUATION	$435,020
														Subtotal = $435,020

Issue Date FY: 2017 ( Subtotal = $443,684 )
2017	2017	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	4	3/29/2017	NON-COMPETING CONTINUATION	$443,684
														Subtotal = $443,684

Issue Date FY: 2016 ( Subtotal = $452,097 )
2016	2016	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	4/15/2016	NON-COMPETING CONTINUATION	$452,097
														Subtotal = $452,097

Issue Date FY: 2015 ( Subtotal = $462,758 )
2015	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	5/13/2015	NON-COMPETING CONTINUATION	$462,758
														Subtotal = $462,758

Issue Date FY: 2014 ( Subtotal = $548,689 ) (Continued on the next page)
Grand Total All Awards = $63,646,591

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Regulation of B cell Responses in SLE and Other Autoimmune Diseases

Award Number: U19AI110483

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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