Wednesday, January 15, 2025 1/15/2025

Sao Paulo-Minas Gerais Tropical Medicine Research Center for Chagas Disease Biomarker Discovery

Award Number: U19AI098461
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT -OVERALL Chagas disease (ChD), caused by infection with the parasite Trypanosoma cruzi, remains one of the world's most neglected diseases with 5.7 million infected people, but only a single partially effective treatment. The lack of good biomarkers for active infection or clinical end-points poses a problem for assessing the performance of new drugs or therapeutic interventions. The Sao Paulo-Minas Gerais Tropical Medicine Research Center (SaMi-Trop) consists of a network of collaborating scientists in the States of Minas Gerais and Sao Paulo which has been established for the purpose of developing and conducting research projects on ChD biomarker discovery and validation. In this proposal, the center will develop three interrelated studies: Project 1 will study the natural history of ChD, in order to recognize prognostic markers related to the risk of progression to cardiopathy, cardiac complications and death. To that effect, we will characterize the clinical evolution of two large cohorts (REDS and SaMi-Trop) to assess the predictable values of biomarkers measured at cohort enrollment. Project 2 will assess if genetic susceptibility modulates disease development. We will use genome wide association study (GWAS) that will combine genetic data from ~5,500 individuals recruited by two NIH-sponsored studies (REDS and SaMi-Trop) and other studies funded by Brazilian Agencies (Bambui, Heart Institute). Project 3 will determine if T cruzi vectorial transmission is reemerging in the Northen Region of Minas Gerais State (a region considered free of domiciliary vector transmission since 2006). We will conduct a large-scale screening survey to detect T. cruzi antibody in schoolchildren’s saliva, and a survey with questionnaires applied to the children’s parents about the prevalence of infestation by triatominae vectors. Two cores (Administrative/Scientific Core and Database and Epidemiology Core) will support activities of the three projects, and will seek to sustain research training capacity for young Brazilian scientists


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$151,071 )
2023	2021	FUNDACAO FACULDADE DE MEDICINA	AVENIDA REBOUCAS 381	SAO PAULO				BRA	Allergy and Infectious Diseases Research	001	10	5/15/2023	NON-COMPETING CONTINUATION	$0
2023	2021	FUNDACAO FACULDADE DE MEDICINA	AVENIDA REBOUCAS 381	SAO PAULO				BRA	Allergy and Infectious Diseases Research	000	10	1/6/2023	NON-COMPETING CONTINUATION	-$151,071
														Subtotal = -$151,071

Issue Date FY: 2021 ( Subtotal = $409,992 )
2021	2021	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP			BRA	Allergy and Infectious Diseases Research	001	10	7/20/2021	NON-COMPETING CONTINUATION	$0
2021	2021	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP			BRA	Allergy and Infectious Diseases Research	000	10	5/24/2021	NON-COMPETING CONTINUATION	$409,992
														Subtotal = $409,992

Issue Date FY: 2020 ( Subtotal = $409,983 )
2020	2020	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	000	9	2/27/2020	NON-COMPETING CONTINUATION	$409,983
														Subtotal = $409,983

Issue Date FY: 2019 ( Subtotal = $442,866 )
2019	2019	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	000	8	3/13/2019	NON-COMPETING CONTINUATION	$442,866
2019	2019	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	001	8	9/5/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $442,866

Issue Date FY: 2018 ( Subtotal = $481,257 )
2018	2018	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	000	7	3/27/2018	NON-COMPETING CONTINUATION	$481,257
														Subtotal = $481,257

Issue Date FY: 2017 ( Subtotal = $484,497 )
2017	2017	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	001	6	8/26/2017	COMPETING CONTINUATION	$140,704
2017	2017	FUNDACAO FACULDADE DE MEDICINA.	AV. REBOUCAS 381	SAO PAULO	SP	05401-000		BRA	Allergy and Infectious Diseases Research	000	6	4/26/2017	COMPETING CONTINUATION	$343,793
														Subtotal = $484,497

Grand Total All Awards = $2,077,524

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Sao Paulo-Minas Gerais Tropical Medicine Research Center for Chagas Disease Biomarker Discovery

Award Number: U19AI098461

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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