Wednesday, October 9, 2024 10/9/2024

Viral and Host Determinants of Infant and Childhood Allergy and Asthma

Award Number: U19AI095227
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The long-term objective of this grant is to define the relationship between infant respiratory syncytial virus (RSV) infection and the host response that enables asthma inception using both a longitudinal birth cohort (Project 1) and a mouse model of RSV infection (Project 2). The goals of Project 1 are two-fold: first to identify RSV strains associated with asthma inception, and second to understand the mechanisms through which these RSV strains cause asthma in humans. To test our hypotheses, we propose to extend longitudinal follow-up of the 1900 children enrolled in the established INSPIRE birth cohort who will be four at the end of the first U19 funding period. This will enable us to confirm if the RSV strains that we have identified to cause more severe infant morbidity and early wheezing outcomes are also associated with asthma development and the pathways through which these RSV strains cause asthma. We propose to test our hypotheses through the following Aims. Specific Aim 1: Identify RSV strains associated with asthma inception and respiratory morbidity at ages 6 to 8 years. Specific Aim 2: Determine how RSV strains differentially impact the host microbial environment during primary RSV infection, if those microbial changes persist with time, and if microbial changes are associated with changes in immune responses and asthma development. Specific Aim 3: Assess primary airway epithelial cell (AEC) response to asthmagenic RSV strains. We will in vitro identify the differential AEC responses from INSPIRE children with their infecting strains and asthmagenic RSV strains. Specific Aim 4: Determine RSV induced memory T cell and innate responses associated with asthma inception in the INSPIRE cohort. We will use non- asthmagenic (control) and asthmagenic strains of RSV to stimulate PBMCs in children with and without RSV-associated asthma at ages 3 and 6 years, and compare responses. We propose an innovative set of studies identifying asthmagenic RSV strains and elucidating mechanisms of RSV-mediated asthma development by determining how RSV strains interact with the host to cause asthma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,620,907 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	15	6/12/2024	NON-COMPETING CONTINUATION	$1,526,769
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	003	15	8/22/2024	SUPPLEMENT FOR EXPANSION	$294,138
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	15	8/2/2024	SUPPLEMENT FOR EXPANSION	$800,000
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	004	15	8/27/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	15	8/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,620,907

Issue Date FY: 2023 ( Subtotal = $1,527,291 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	14	5/24/2023	NON-COMPETING CONTINUATION	$1,527,291
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	14	7/31/2023	NON-COMPETING CONTINUATION	$0
2023	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	11	7/21/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,527,291

Issue Date FY: 2022 ( Subtotal = $1,493,162 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	004	13	8/2/2022	NON-COMPETING CONTINUATION	$1,493,162
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	007	13	8/26/2022	NON-COMPETING CONTINUATION	$0
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	003	12	3/24/2022	COMPETING CONTINUATION	$250,068
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	11	11/5/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	006	11	8/19/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	005	11	8/18/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	11	11/5/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	11	3/24/2022	NON-COMPETING CONTINUATION	-$250,068
														Subtotal = $1,493,162

Issue Date FY: 2021 ( Subtotal = $1,681,915 )
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	11	12/14/2020	SUPPLEMENT FOR EXPANSION	$164,815
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	12	8/2/2021	COMPETING CONTINUATION	$1,517,100
														Subtotal = $1,681,915

Issue Date FY: 2020 ( Subtotal = $4,501,441 )
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	003	11	9/1/2020	SUPPLEMENT FOR EXPANSION	$1,550,210
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	11	6/23/2020	NON-COMPETING CONTINUATION	$1,343,390
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	005	10	9/18/2020	SUPPLEMENT FOR EXPANSION	$102,000
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	10	4/23/2020	SUPPLEMENT FOR EXPANSION	$1,505,841
2020	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	004	10	9/18/2020	NON-COMPETING CONTINUATION	-$102,000
2020	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	10	2/21/2020	NON-COMPETING CONTINUATION	$102,000
														Subtotal = $4,501,441

Issue Date FY: 2019 ( Subtotal = $1,380,535 )
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	10	7/9/2019	NON-COMPETING CONTINUATION	$1,380,535
														Subtotal = $1,380,535

Issue Date FY: 2018 ( Subtotal = $1,485,056 )
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	9	8/7/2018	NON-COMPETING CONTINUATION	$1,390,256
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	9	8/30/2018	NON-COMPETING CONTINUATION	$94,800
														Subtotal = $1,485,056

Issue Date FY: 2017 ( Subtotal = $1,407,057 )
2017	2017	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	003	8	7/25/2017	NON-COMPETING CONTINUATION	$1,407,057
2017	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	7	5/4/2017	COMPETING CONTINUATION	$0
2017	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	7	2/15/2017	COMPETING CONTINUATION	$156,379
2017	2015	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	6	2/15/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$156,379
														Subtotal = $1,407,057

Issue Date FY: 2016 ( Subtotal = $1,828,520 )
2016	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	003	7	8/4/2016	COMPETING CONTINUATION	$352,229
2016	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	7	6/30/2016	COMPETING CONTINUATION	$1,474,875
2016	2015	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	6	5/9/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$226,280
2016	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	5	5/9/2016	NON-COMPETING CONTINUATION	-$224,864
														Subtotal = $1,828,520

Issue Date FY: 2015 ( Subtotal = $1,900,883 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	5	8/12/2015	NON-COMPETING CONTINUATION	$0
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	5	7/15/2015	NON-COMPETING CONTINUATION	$1,900,883
														Subtotal = $1,900,883

Issue Date FY: 2014 ( Subtotal = $2,656,082 ) (Continued on the next page)
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	002	4	8/20/2014	NON-COMPETING CONTINUATION	$699,997
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	001	4	8/7/2014	NON-COMPETING CONTINUATION	$0
Grand Total All Awards = $30,371,806

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Viral and Host Determinants of Infant and Childhood Allergy and Asthma

Award Number: U19AI095227

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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