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Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal

Award Number: U19AI089674
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2010
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal - Summary/Abstract Malaria remains one of the most important global health challenges, with an estimated 247 million cases and 619,000 deaths in 2021, of which 95% of cases and 96% of deaths were in the WHO Africa region. The scale up of proven control interventions resulted in significant reductions in the burden of malaria following the turn of the century. However, since 2015 progress has stalled and even reversed course in some of the highest burden countries of Africa. Indeed, a myriad of challenges, including the spread of insecticide resistance, changes in vector composition and behavior, the emergence of artemisinin partial resistance, and the COVID- 19 pandemic have created a precarious situation. Our program called “PRISM” has been based in Uganda, representing the East African region for the International Centers of Excellence for Malaria Research network. Uganda is emblematic of the challenges faced by high burden countries, where routine surveillance systems are inadequate to assess trends in the burden of malaria or to monitor the impact of control interventions. Through PRISM we have implemented a comprehensive malaria surveillance program including enhanced health facility-based surveillance and detailed longitudinal studies. Complementary laboratory-based studies include surveillance for markers of antimalarial drug and insecticide resistance and serologic measures of malaria exposure. These studies have greatly improved our understanding of the epidemiology of malaria in Uganda and of the impact of control interventions. In this renewal application we propose to continue key components of our health facility and community-based malaria surveillance to strategically focus on quantifying the impact of malaria control interventions, working in close collaboration with our partners at the Uganda National Malaria Control Division (NMCD). We will utilize specimens collected from our surveillance system to generate genomic and serologic data to address key questions about malaria epidemiology, transmission, diagnostics, and antimalarial drug and insecticide resistance. The central theme of our program will be to improve malaria surveillance to better assess the impact of malaria control interventions and guide evidence-based utilization of existing and novel interventions to reduce the malaria burden using an adaptive approach. The program will consist of three research projects linked together in an integrated manner to maximize scientific discovery. Research Project 1 (Surveillance and Impact Evaluation Project) will utilize health facility and community-based malaria surveillance data from sites with varied transmission intensity and control interventions to monitor trends, estimate the impact of interventions, and provide clinical data and specimens for our other research projects. Research Project 2 (Resistance Project) we will characterize the evolution of genotypic markers of drug and insecticide resistance and assess the impacts of resistance on malaria transmission. Research Project 3 (Molecular Epidemiology Project) will characterize key parasite and vector genomic traits and human serological responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $891,729 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	17	5/12/2026	SUPPLEMENT FOR EXPANSION	$590,328
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	17	4/30/2026	NON-COMPETING CONTINUATION	$276,880
2026	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	16	2/18/2026	NON-COMPETING CONTINUATION	$24,521
														Subtotal = $891,729

Issue Date FY: 2025 ( Subtotal = $867,208 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	16	9/22/2025	NON-COMPETING CONTINUATION	-$559,182
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	16	8/29/2025	SUPPLEMENT FOR EXPANSION	$31,146
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	004	16	9/22/2025	SUPPLEMENT FOR EXPANSION	$559,182
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	16	8/27/2025	NON-COMPETING CONTINUATION	$836,062
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	14	4/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $867,208

Issue Date FY: 2024 ( Subtotal = $867,208 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	15	7/19/2024	COMPETING CONTINUATION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	15	8/8/2024	COMPETING CONTINUATION	$80,000
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	15	4/30/2024	COMPETING CONTINUATION	$787,208
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	14	11/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $867,208

Issue Date FY: 2023 ( Subtotal = $2,015,603 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	14	4/26/2023	NON-COMPETING CONTINUATION	$2,015,603
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	13	12/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,015,603

Issue Date FY: 2022 ( Subtotal = $1,987,010 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	13	4/28/2022	NON-COMPETING CONTINUATION	$1,987,010
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	12	11/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,987,010

Issue Date FY: 2021 ( Subtotal = $2,743,564 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	12	8/5/2021	NON-COMPETING CONTINUATION	$738,044
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	12	4/23/2021	SUPPLEMENT FOR EXPANSION	$783,771
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	12	3/22/2021	NON-COMPETING CONTINUATION	$1,221,749
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	11	3/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,743,564

Issue Date FY: 2020 ( Subtotal = $1,699,128 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	11	3/27/2020	NON-COMPETING CONTINUATION	$1,699,128
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	10	11/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,699,128

Issue Date FY: 2019 ( Subtotal = $1,732,262 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	10	3/8/2019	NON-COMPETING CONTINUATION	$1,257,243
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	10	4/9/2019	SUPPLEMENT FOR EXPANSION	$475,019
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	9	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,732,262

Issue Date FY: 2018 ( Subtotal = $1,403,277 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	9	3/23/2018	NON-COMPETING CONTINUATION	$1,300,815
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	9	5/1/2018	NON-COMPETING CONTINUATION	$102,462
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	8	10/23/2017	COMPETING CONTINUATION	$147,539
2018	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	7	10/23/2017	EXTENSION WITH OR WITHOUT FUNDS	-$147,539
														Subtotal = $1,403,277

Issue Date FY: 2017 ( Subtotal = $1,317,799 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	8	8/14/2017	COMPETING CONTINUATION	$0
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	8	4/12/2017	COMPETING CONTINUATION	$1,317,799
2017	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	7	1/24/2017	EXTENSION WITH OR WITHOUT FUNDS	$215,084
2017	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	6	1/24/2017	NON-COMPETING CONTINUATION	-$215,084
														Subtotal = $1,317,799

Issue Date FY: 2016 ( Subtotal = $1,879,403 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	7	6/30/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,879,403
														Subtotal = $1,879,403

Issue Date FY: 2015 ( Subtotal = $2,058,846 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	6	6/19/2015	NON-COMPETING CONTINUATION	$2,058,846
														Subtotal = $2,058,846

Issue Date FY: 2014 ( Subtotal = $2,239,502 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	5	6/27/2014	NON-COMPETING CONTINUATION	$2,039,700
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	5	8/8/2014	NON-COMPETING CONTINUATION	$199,802
														Subtotal = $2,239,502

Grand Total All Awards = $29,018,895

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Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal

Award Number: U19AI089674

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2010

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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